Eleanor Sanderson

How much does a child's BMI affect their depression, anxiety, or ADHD symptoms? Not much, suggests our new research which accounts for family-level factors. Read it here: elifesciences.org/articles/74320. With @ECSanderson @nm_davies @laurahowe_epi @alexhavdahl @bristimtom @mrc_ieu

Check out our new Editor’s Pick from @JBMRPlus Associate Editor Emma Clark @emcbristol! A Guide for Understanding and Designing Mendelian Randomization Studies in the Musculoskeletal Field @MRC_IEU @Brms_Research @BristolUni (1/6) doi.org/10.1002/jbm4.1…

This Primer explains Mendelian randomization - from concepts to required conditions - and describes key applications and applying the technique to growing genomic datasets @MariaGlymour @mvholmes @MarcusMunafo @jeanv_morrison @chr1swallace go.nature.com/3x3IIJc

Interpretation of Mendelian randomization using a single measure of an exposure that varies over time doi.org/10.1093/ije/dy…

So excited to see our UK Biobank study comparing intergenerational instrumental variable analyses of BMI on mortality published in @IntJEpidemiol !! academic.oup.com/ije/advance-ar… 🥳

New paper assessing causality of DNA methylation associations with prevalent type 2 diabetes. Congratulations to @Dianajuvi89 for leading the work, very lucky to work with you! @carolinerelton @ECSanderson @ammegandchips @mrc_ieu #diabetes #MR medrxiv.org/cgi/content/sh…

Mendelian randomization outlined by ⁦@ECSanderson⁩ at #Mendel200

New preprint out! In it we propose a (simple!) solution to the bias caused in Mendelian randomization from covariate adjusted GWAS statistics doi.org/10.1101/2022.0… Led by PhD student Joe Gilbody, also thanks to @MCarol_Borges and @mendel_random!

This is happening tomorrow! Thank you to all our speakers, helpers and all who've registered to join us (not too late if you want to join us online!). See you tomorrow! #Mendel200

Thanks to everyone involved with this! @mendel_random @iTomRichardson @bristimtom and Kate Tilling!

Our new paper on using Multivariable MR with multiple measures of a single exposure was published today. In it we discuss the approach, the assumptions required and interpretation of the results. doi.org/10.1371/journa…

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization dlvr.it/SV6bJ6

Interpretation of Mendelian randomization using a single measure of an exposure that varies over time dlvr.it/SV5x4N

Finally: causal estimates for adiposity & metabolomic traits at scale! Pleased to share the first large-scale comparison of conventional vs MR approaches in UK Biobank in @LancetRH_Europe sciencedirect.com/science/articl… Key takeaways:

Our preprint “Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study” is now available: medrxiv.org/content/10.110…

Excited to thumb through an actual hard copy of the book “Combining Human Genetics and Causal Inference to Understand Human Disease and Development” edited with @BeckyRichmond90 and Jean-Baptiste Pingault, a thread on what it contains /cont

See the programme for our upcoming #Mendel200 conference to celebrate the bicentenary of Gregor Mendel. A great line up of speakers and topics. Join us online (free) or in person in Bristol, UK (small, subsidised price) bristol.ac.uk/integrative-ep…

From pea plants to better understanding of public health ... our upcoming conference celebrates the 200th birthday of Gregor Mendel, his legacy and the range of research his work has inspired. Join us in person in Bristol or online on 20-21 July #Mendel200 bristol.ac.uk/integrative-ep…

A limited number of in-person places now available at the “Mendel @ 200” meeting 20-21st July. shop.bris.ac.uk/conferences-an…

**Funded PhD studentship at University of Bristol - to develop methods for applying Mendelian randomization in diverse populations and to apply these to identify risk factors for gallbladder cancer findaphd.com/phds/project/p…