Epigenomic Mechanisms in Human Disease

-expressed genes. It highlights the fascinating, intertwined nature of developmental and ageing-related pathways. Thanks to @impetusgrants @hevolution_f [2/2] #CpG #ucCpGs #epigenomics #DNAmethylation #ageing #aging #populationgenetics @QMULepigenetics doi.org/10.64898/2026.…

BioRxiv preprint from us identifying ultra-conserved Human CpG Dinucleotides - the crucial motif for DNA methylation in differentiated cells - from >0.5 million whole genome sequences (UKB/gnomAD). This identified enriched signals in developmental, ageing and brain... [1/2]

Quantifying stochasticity in the ageing DNA methylome - comment on the 3 recent @NatureAging papers nature.com/articles/s4358… Viewable link here - rdcu.be/dH6Nv @qmulepigenetics #epigenetics #DNAmethylation #ageing #aging

📎Now see the associated News & Views from Christopher Bell, covering all three studies @EpigenomicMed nature.com/articles/s4358… rdcu.be/dH7co

Great review article on "Epigenomic insights into common human disease pathology" by Chris Bell from QMUL Centre for Epigenetics link.springer.com/article/10.100…

link.springer.com/article/10.100… #epigenomics #commondisease

We have two new faculty opportunities at QMUL, part of a £3.2M investment by @Barts_Charity to develop genomic and epigenomic liquid biopsy analyses for diagnostics and research applications. More details here: qmulepigenetics.com/jobs Please RT abundantly

Early and accurate diagnosis saves lives. With our funding, teams @QMUL @blizard_inst and @nhsbartshealth will investigate how the marks on our DNA unlock vital genetic information to diagnose a much wider range of diseases than ever before.

Great to be involved in this work, just in the press. A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain pubmed.ncbi.nlm.nih.gov/37777763/ @blizard_inst @QMUL @QMULBartsTheLon @QMULWHRI @QMUL_LSI @QMBCI

Hundreds of Hypertension-Related Effector Genes Identified in Genetic Fine-Mapping Study. Investigators used genetic fine mapping and multiomics to identify 436 blood pressure-related candidate effector genes, some of which could become drug targets.  ow.ly/F6Oh104TFa2

Scientists from @QMUL @OfficialUoM @unizar @UniofOxford reveal the genetic underpinnings of blood pressure regulation, offering hope for more effective treatments and preventative measures for hypertension. bit.ly/4600mw3 @ManchesterBRC @BartsBRC @AJHGNews @NIHRresearch

📢 New publication from our lab spearheaded by @Emilysaun, a truly collaborative work with Bonnet lab (Crick) @DrHHEncabo and Marion Piganeau, @EpigenomicMed @JulieDevis J. Gribben and @kevin_rouault pnas.org/doi/10.1073/pn… This story aims to disentangle cause and consequence..🧵

Interviewed in National Geographic about the AI-driven assessment of ‘biological’ age - through facial & other modalities - and ageing-related diseases nationalgeographic.co.uk/science-and-te… #ageing #chronicdisease @QMULepigenetics @QMULWHRI @DERI_QMUL @QMULBartsTheLon

Don't miss this exciting #postdocjobs to join Chris Bell's lab in London @qmulepigenetics, @QMULWHRI in #epigenomics #Ageing – exploring the functional impact of the DNA methylome in ageing/ageing-related disease. Funded by @impetusgrants apply here qmul.ac.uk/jobs/vacancies…

📢In our latest preprint we prioritise 394 consolidated effector genes for hypertension🩸by integrating fine-mapping and multi-omics 🧬 biorxiv.org/content/10.110…

We have a post-doctoral position available in epigenomics & ageing – exploring the functional impact of the DNA methylome in ageing/ageing-related disease. Funded by @impetusgrants qmul.ac.uk/jobs/vacancies… @QMULWHRI @qmulepigenetics #epigenomics #ageing

Nature research paper: A DNA methylation atlas of normal human cell types go.nature.com/3idcUgn

Please join us for @qmulepigenetics event at @blizard_inst for the focused meeting on "DNA-on-repeat" (in person only) on 14th Dec 2022. We will have talks, posters, X-mas jumper competition & drinks. Pl submit abstracts for talks & posters, details 👇 qmulepigenetics.com/dnaonrepeat

Live from LA, it's #ASHG22 ☀️ We are so excited to welcome you back in person for five days of breakthrough science! ➡️ bit.ly/3Szugju

BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”