Frank Maggiore

@RuxandraTeslo @WorksInProgMag I did an episode on KRAS Cancers and how daraxonrasib and SIL-204 are used for these cancers that were considered undruggable previously - youtu.be/YwEzCQJlgy4?si…

This April, we got a drug revolutionary in 3 ways: daraxonrasib roughly doubles survival in metastatic pancreatic cancer, cracked RAS, a protein deemed untreatable for decades & pioneered a drug class called molecular glues. Read more in my piece @WorksInProgMag worksinprogress.news/p/pancreatic-c… - Pancreatic cancer is a particularly tough cancer. - It's diagnosed late in its progression and it coats itself with tissue that block the immune system from attacking it. This makes immunotherapies, which have been revolutionary in other metastatic cancers (e.g. melanoma) ineffective against it. - 90% of pancreatic cancer have one mutated protein: RAS. This should make it easily targetable. But ... not so quick! - RAS has a property that has made it "undruggable" for decades: it largely lacks the pockets or grooves that most drugs depend on to bind and act upon their target. - Molecular glues sidestep the problem entirely. Instead of binding a pocket, daraxonrasib forces two proteins together — locking RAS in its inactive state by wedging a third protein in the way. - The result: median survival of 13.2 months vs ~6 on standard chemo. Not a cure, but a genuine doubling, delivered as a daily pill. - The implications go far beyond pancreatic cancer. RAS is mutated in lung, colorectal, and many other cancers. Molecular glues are now being developed against multiple other "undruggable" targets. The assumption that certain proteins are simply beyond reach has turned out, repeatedly, to be wrong. - The bad news is that most patients eventually develop resistance mutations that vary from patient to patient. In order to deliver a real cure, we need to rethink our regulatory system and make small-n, early stage bespoke trials much easier to run.

Stop trapping your AI in a box. That box will never be big enough 📦 Many manufacturers are running AI point solutions for individual systems — and none of them are talking to each other. That's not intelligence; that's expensive automation with extra steps. So how do you achieve real end-to-end intelligence and connectivity across your manufacturing operations? 👇 @angelostracq chats with @CWLuecke for @MfgHappyHour

@angelostracq dives into Apprentice's A1 Agents - an agent for every role, automating the work you're spending hours on manually with @CWLuecke for @MfgHappyHour

@rightish19 @sgodofsk Amateur. You need to get Greenland, Iceland, and New Zealand out of the way first.

@sgodofsk everyone knows you target islands first in plague inc

Okay so she 1. Got on a cruise ship to St. Helena 2. Took the weekly 5hr flight to Johannesburg 3. Took a daylong connecting flight back to San Francisco 4. Flew to ~8hrs to Tahiti, then 1hr to Mangareva, from SF 5. Took a 2 day boat ride to Pitcairn WTF forget the virus thing

What happens when anonymous traders start betting billions on whether cancer drugs succeed or fail? The rise of prediction markets in clinical research is creating serious insider trading risks, data security threats, and ethical questions no one is prepared to answer. Check out the latest episode of Industry Insights 🎙️ Link in comments

Had a blast chatting with Chris about everything from entrepreneurship to AI in manufacturing - hope we can get a real happy-hour wine at Laicos in Jersey City soon!

@ATinyGreenCell Game over screen, no continues left— You should stick to the booth, not a digital death. I don’t battle rappers—I dismantle threats, And you ain’t even close to my hardest set.

Important news update:

@ATinyGreenCell You talk Wu-Tang, but I roll with Rush and Beat, Robotic precision—every line obsolete. You bring a mic, I bring a charge shot blast, You’re a moment in the booth—I’m a legacy that lasts.

@ATinyGreenCell You ain’t a boss, you a bonus round at best, I fight geniuses gone mad, you just hype in a vest. Wily builds empires just to fall at my feet— So how you think you stepping up to a machine elite?

@ATinyGreenCell Dr. Wily raised the stakes, I break ‘em every time, You couldn’t beat my weakest bot with your sharpest rhyme. Metal Blades spinning—cut your whole persona down, You a Staten Island king? I’m a world-saving crown.

@ATinyGreenCell Mega Man Rap Battle: I’m the Blue Bomber, built for war, you just rap for fame, You Method Man, but you ain’t ever faced a method of pain. I’ve been through eight-bit hell, upgraded every stage, While you still stuck in verses, I evolve with every page.

@angelostracq Interphex was great this year! There was tremendous interest in the A1 Agentic AI platform from Apprentice.

Interphex 2026 is a wrap! Honored to be the Keynote talking about Physical AI -  lots of interesting learnings from largest pharma manufacturing tradeshow of the year! > Concern and optimism about 100% tariff impact on 53% of patented drugs made globally going into effect July 31st > Physical AI big buzz of the year to automate and orchestrate equipment / sensors / systems / people > Robotics from AMRs (mobile robotics for material movement), to 6 axis arms for cell to cell automation, and higher throughput automation equipment > Self-contained and deployable mobile manufacturing units > New materials being used in single-use that are easier to produce and better for the environment

The Manufacturing AI Company is here. The first standalone AI built exclusively for manufacturing. Deployable across any system. Untethered to any product. No one else is building this. No one else has a model trained specifically for this industry. Not a chatbot. Not advice — execution, with human-in-the-loop. That's A1. Available now.

Manufacturing AI has been a buzzword for years. A1 is the first time it's actually real. Not a chatbot. Not a copilot. An autonomous AI agent that executes real manufacturing workflows — on its own. Listen in as @angelostracq covers the launch that changed the conversation entirely. Link in comments 👇

@DaveShapi @jasminewsun Yeah. I worry we are entering into a neo-feudalism phase as a default option and won’t have the political will to make the changes to prevent this until it is already too late.

@jasminewsun It's actually way worse than a permanent underclass. "underclass" implies that there's still a class at all. The reality is closer to "useless eaters" or "redundant biomass"

Most people I know in AI think the median person is screwed, and they have no idea what to do about it. I spent the last 3 months talking to dozens of researchers, economists, and policy experts about AI's impact on work; including reps from every frontier lab and several Congressional offices. Unfortunately, I was not reassured. The AI industry is raising the alarm, but can't change course. These companies' core business model relies on the disruption they are warning about: their faith in full automation only makes them go faster. Policymakers are waking up, but still paralyzed by data and debates. Econ wonks disagree on plenty, but even the limited scenario looks like a "painful transition" that will disempower millions of workers. But an "underclass" is not inevitable, but rather a societal choice — and one we can and should stop. Instead of waiting for impact, we should start planning now to support workers through AI disruption. Whether policymakers can assuage concerns about economic security may determine if we get to reap AI's gains at all. New from me for @NYTOpinion. I put a ton into researching what I think may be the biggest topic of the year, so hope you read it (gift link here!) nytimes.com/2026/04/30/opi…

@foundrceo @suni_code He keeps knocking it off the table though 🐈.

@suni_code next step: teaching my cat to do genomics. 🐱

> Random Guy with no Biology Degree > zero Lab experience > asked Claude how to build a wet lab at Home > extracted DNA and sequenced his own genome > Using a $1,000 device: MinION > barrier has never been this lower Reddit users are way ahead of avg peoples.

Honored to be the Keynote at Interphex 2026 (my favorite conference of the year!) - talking about AI in Manufacturing!

@angelostracq Great interview digging deep into an array of interesting topics. Be sure to check out the full interview as it has great information on the new Apprentice A1 AI Agent, how to save operators time, and the future of AI in manufacturing.

The most common question I get about Manufacturing AI is, "what's in it for me...?" Take the things that are painful every day, that cause stress and friction and annoyance and frustration, and just have the AI go do that. There's no reason why at the end of a long shift you have to manually compile your notes, or at 2am manually dig through a SOP to find the right troubleshooting step, or manully compile data from 10 different manufacturing systems to find the common trend - that's what the AI is for. Let it be your digital Apprentice.