Frederik Schaltz-Buchholzer

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Frederik Schaltz-Buchholzer

Frederik Schaltz-Buchholzer

@FSBuchholzer

MD PhD, Assistant Professor at Bandim Health Project @SyddanskUni. Vaccine trials & epi. Father of 2, polyglot. WhatsApp (+45) 42702170 ✉️ [email protected]

Copenhagen Katılım Aralık 2014
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Frederik Schaltz-Buchholzer
Frederik Schaltz-Buchholzer@FSBuchholzer·
Big step forward for neonatal health👶: New 🇮🇳 BLOW2 RCT (n=5,420; 511 deaths) shows BCG+OPV at birth reduce neonatal mortality by 17 % (NNT≈21) and ↓ infection deaths by 47 %. A landmark confirmation of the Guinea-Bissau 🇬🇼 discovery of BCG’s life-saving non-specific effects.
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Frederik Schaltz-Buchholzer
Frederik Schaltz-Buchholzer@FSBuchholzer·
@MBrgger Jeg går ud fra, at du har bemærket at Moraes som ledte denne sag er bundkorrupt? x.com/i/status/20318…
KanekoaTheGreat@KanekoaTheGreat

🚨BOMBSHELL: Brazilian Supreme Court Justice Alexandre de Moraes — the same judge who clashed with @elonmusk during Brazil’s 2024 push to ban X — is now facing growing calls for impeachment and arrest. The pressure stems from a massive banking-fraud scandal linked to the collapse of Banco Master. Moraes’ wife's law firm reportedly received about $25M in legal-services fees from the bank before it imploded amid a multibillion-dollar fraud probe. Federal Police forensic analysis of jailed banker Daniel Vorcaro’s phone reportedly uncovered WhatsApp messages sent to Judge Moraes on the morning of Vorcaro’s November 17, 2025 arrest, asking whether he had managed to “block” his arrest as authorities closed in. Investigators say Moraes replied with “view-once” messages that automatically disappear after being opened, leaving their contents unrecoverable. Police also reportedly identified earlier disappearing or deleted exchanges, phone calls between the two, and messages in which Vorcaro described meeting Moraes in 2025. Moraes has denied the messages were his — but Brazilian newspaper O Globo reported this week that a Federal Police technical analysis linked the phone number directly to the Supreme Court justice. In 2024, Elon Musk labeled Moraes "the dictator of Brazil" and warned that the Justice "repeatedly and egregiously violates Brazilian law." Musk famously predicted: "Moraes will end up in prison for his many crimes. That is his destiny," even posting an AI-generated image of Moraes behind bars with the warning, "This picture of you in prison will be real. Mark my words." Now, a growing coalition of Brazilian officials are demanding that Moraes face impeachment and criminal charges. Can Brazil successfully remove the corrupt dictator running its juristocracy? Only time will well. Video: @gazetadopovo

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Frederik Schaltz-Buchholzer
Frederik Schaltz-Buchholzer@FSBuchholzer·
@MagnusBarsoe Jamen de folk betaler jp vanvittigt meget i skat til fællesskabet? Top-top skat osv. Så hvad er problemet egentlig ved, at de får en høj løn?
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Magnus Barsøe
Magnus Barsøe@MagnusBarsoe·
Et lønhop på 61 mio. kr. på et år til syv Lego-topledere (!) Hvor er det patetisk og uværdigt, at man samtidig skal høre Lego-topchefen klynke over en mulig formueskat. Den nostalgiske ide om den socialt ansvarlige danske rigmand, der godt kan se, at et progressivt skattesystem giver mening, at Arne skal have ret til en tidlig pension, og at ulighed er gift for et samfund, er død. Ind er kommet den socialt ansvarsløse og privilegieblinde yuppie, der gerne skrider til Schweiz eller Dubai for at undgå skattefar, så snart han har landet sin første million. Alle venstreorienterede er kommunister, og enhver ide om at beskatte de rigeste eller forargelse over svimlende millionlønninger er simpel misundelse. Rigdom er gud, og Liberal Alliance er deres tempel. Selv i vores tidligere så stolte familieejede selskaber er grådigheden og den totale ligegyldighed overfor fællesskabet begyndt at gennemsyre alt. Hvor er det dog fattigt og helt igennem udansk.
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F. Perry Wilson, MD MSCE
F. Perry Wilson, MD MSCE@fperrywilson·
We're all aging. I want to slow it down as much as you do. But this trial shows small, likely spurious effects on imprecise surrogate markers with no connection to clinical outcomes. Get your micronutrients from food. Full write-up: buff.ly/n9fUjcV
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F. Perry Wilson, MD MSCE
F. Perry Wilson, MD MSCE@fperrywilson·
"A daily multivitamin slows biological aging." That's the headline from a new Nature Medicine paper. From a randomized trial! But when you actually read the data, the vitamin is doing just about nothing. Thread.
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Swan
Swan@AndySwan·
Dermatologist: don't forget your sunscreen! Every day! Me:
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Prof. Peter C Gøtzsche
Prof. Peter C Gøtzsche@PGtzsche1·
FDA is so totally corrupt and so totally steered by Big Pharma’s useful idiots among politicians, the media and patient organisations that it will never come to work for patients. When FDA finally employed the right person, Vinay Prasad, they fired him twice: bit.ly/4sw37Aj.
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Nick Mullen
Nick Mullen@NickMullenMDPhD·
$qure Serious Q: If you think the FDA should approve any drug (let alone a brain injection that’s $3M a pop) based on a negative RCT with N<40 and a “study” that gave it to 12 people who were then compared to a “historical control” cohort, why not just abolish the FDA?
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Allison Krug MPH
Allison Krug MPH@KrugAlli·
@VPrasadMDMPH is one of the scarce few truth-tellers in medicine today. He is brilliant, ethical, honest, yes - decisive - and funny. This is a tremendous loss to the FDA and the American public. I do wish Makary or Trup had been able to push back against the corruption. Vinay once said on a pod during the pandemic - do the work, then step into the ring. He has opinions because he does the work, he knows the data. How many of those who disagree with him have the intellectual honesty (or skill) to even ask the right questions, let alone interpret the data. This is a great loss. I'd be sad longer if I weren't convinced VP would be on to more gratifying endeavors and other pursuits that will continue to elevate the practice of medicine. Best wishes to you, VP! Can't wait to see what is next. @anish_koka - absolutely brilliantly written. How in the world do you do it all?!
Anish Koka, MD@anish_koka

x.com/i/article/2030…

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Bryce Nickels
Bryce Nickels@Bryce_Nickels·
Hope we will someday get a full and honest account of Vinay Prasad's tenure at the FDA. Based on the way he was covered in the media, he came to DC with a set of core principles and did not allow the vicious smears to compromise them one bit. By all appearances, he emerges from this tumultuous year as a person who proved himself to be of extremely rare integrity.
Dr. Marty Makary@DrMakaryFDA

A year ago, Dr. Prasad came to the FDA to implement 4 major long-lasting reforms: 2-to-1 pivotal trial requirement, national priority reviews, a risk-stratified covid vaccine framework, & the new plausible mechanism framework for ultra rare diseases which we launched last week. Also, under his leadership, his center hit a record number of approvals in Dec. He got a tremendous amount accomplished within his one-year sabbatical from UCSF and will be returning back to his academic home later next month. We will name a successor before his departure. I want to thank him for his service and personal sacrifice to take time away from his family.

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Frederik Schaltz-Buchholzer
Frederik Schaltz-Buchholzer@FSBuchholzer·
@matthewshaw1111 The claim that a vaccine given from earliest ~5 months of age can reduce infant mortality by 50% is also complete impossible, because most infant deaths occur BEFORE 5 months of age x.com/FSBuchholzer/s…
Frederik Schaltz-Buchholzer@FSBuchholzer

@gavi Given that RTSS is provided from 5 months of age and infant deaths between 5-12 months of age are 15-20% of deaths during infancy (neonatal deaths alone ~ 50%), I find a 50% reduction extremely hard to believe. Mortality was also *increased* in the RCT: pmc.ncbi.nlm.nih.gov/articles/PMC48…

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Matthew Shaw
Matthew Shaw@matthewshaw1111·
This is very strange. Global health organizations (in Gavi's post and in this 2023 Science article) are announcing huge overall mortality reductions attributed to malaria vaccine, but they are doing so via press releases rather than published studies. These claims are very hard to believe given what we know from the malaria vaccine clinical trials: x.com/matthewshaw111… Where are the real data used to arrive at these conclusions? @StabellBenn @FSBuchholzer /1
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Gavi, the Vaccine Alliance@gavi

Over 200,000 children were vaccinated against malaria in Nigeria's Kebbi State in one year. Now? 👉 Under-five mortality is down from 8.97% to 6.13% 👉 Infant mortality: nearly halved. 👉 Hospitalisations have dropped 50%. Here’s how one year of vaccinations have made a big impact in Nigeria: bit.ly/46DVEqy

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Frederik Schaltz-Buchholzer
Frederik Schaltz-Buchholzer@FSBuchholzer·
@gavi Given that RTSS is provided from 5 months of age and infant deaths between 5-12 months of age are 15-20% of deaths during infancy (neonatal deaths alone ~ 50%), I find a 50% reduction extremely hard to believe. Mortality was also *increased* in the RCT: pmc.ncbi.nlm.nih.gov/articles/PMC48…
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Gavi, the Vaccine Alliance
Gavi, the Vaccine Alliance@gavi·
Over 200,000 children were vaccinated against malaria in Nigeria's Kebbi State in one year. Now? 👉 Under-five mortality is down from 8.97% to 6.13% 👉 Infant mortality: nearly halved. 👉 Hospitalisations have dropped 50%. Here’s how one year of vaccinations have made a big impact in Nigeria: bit.ly/46DVEqy
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Frederik Schaltz-Buchholzer
Frederik Schaltz-Buchholzer@FSBuchholzer·
@matthewshaw1111 And the data in question, used to "document" the 13% decline, is of much lower quality than the double-blind RCT data. It simply can't be used to "overrule" what our best dataset says, which is that the vaccine increases female mortality and even increased mortality from malaria.
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Matthew Shaw
Matthew Shaw@matthewshaw1111·
For example, here's a study repeating the 13% mortality reduction claim. But their references are to materials that are essentially WHO press releases. /2 #R11" target="_blank" rel="nofollow noopener">pmc.ncbi.nlm.nih.gov/articles/PMC11…
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Human Progress
Human Progress@HumanProgress·
75 years ago, 1 out of every 5 dollars a US family earned went to food. Today that's closer to 1 in 10. A slow, steady, easy-to-miss kind of progress.
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The Real Truther
The Real Truther@thereal_truther·
It's not "silly." It's factual. Nobody is here "refuting" your claims because your claims have not been proven. When I asked for reproduced science I meant from independent researchers with no connection to your group. The facts are the study you shared on hep-b does not use the vaccine we use in the USA, it focused on a small subcohort of 876 children within a two-dose measles vaccine trial, the confidence interval for the key mortality rate ratio was wide, suggesting low statistical power, uncertainty, and potential for overfitting or noise in the results and as a small observational study comparing cohorts over time it is extremely susceptible to confounding from unmeasured factors such as secular trends in healthcare access, nutrition, or other environmental changes not to mention selection bias. Studies in high-income cohorts often show different results, with no increase in all-cause mortality from the hepatitis B vaccine, and frequently benefits. And finally the claimed "sex-differential harm" has not been replicated consistently. Evidence from reviews is inconsistent, with some low and middle-income country studies showing mixed or no sex-specific mortality differences after hepatitis B vaccination. I think a full investigation is warranted here for how this $1.7 million payment was authorized and it's possible we need to even bring in criminal charges.
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The Real Truther
The Real Truther@thereal_truther·
You can't answer? A) Was that study using the same vax given in the USA? B) Did it focus only on a small subcohort within a measles vaccine trial? C) Did it have wide confidence intervals indicating low statistical power and potential overfitting to noise? D) Was there confounding from unmeasured factors like changes in healthcare access or nutrition over time? Selection bias? E) Do other studies in high-income cohorts show different results? For example do multiple large studies/reviews find no increase in all-cause mortality from HBV (and often benefits beyond hepatitis prevention?) F) Has the claimed sex-differential harm been replicated consistently?
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The Real Truther
The Real Truther@thereal_truther·
A) Was that study using the same vax given in the USA? B) Did it focus only on a small subcohort within a measles vaccine trial? C) Did it have wide confidence intervals indicating low statistical power and potential overfitting to noise? D) Was there confounding from unmeasured factors like changes in healthcare access or nutrition over time? Selection bias? E) Do other studies in high-income cohorts show different results? For example do multiple large studies/reviews find no increase in all-cause mortality from HBV (and often benefits beyond hepatitis prevention?) F) Has the claimed sex-differential harm been replicated consistently? See here "HBV vaccination was associated with reduced risk of all-cause mortality" pubmed.ncbi.nlm.nih.gov/34855999/ See here for why this proposed study is a problem: retractionwatch.com/2026/02/10/gue… I still think an investigation on the unsolicited $1.6 million grant must be done. If not now then if/when democrats take the presidency in 2028 and RFK is removed within minutes along with all his policies being reversed.
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Keşfet

@MBrgger @MagnusBarsoe @fperrywilson @Sensible__Med @AndySwan @VPrasadMDMPH @anish_koka @matthewshaw1111