Fabio Grizzi

Almost all organs and tissues in the body can develop tumours, but those that affect the heart are seldom observed go.nature.com/4d7vRcT

Online now: Collective social niche construction shaping adaptive social networks dlvr.it/TS9GkS

New online! Extracellular matrix remodelling in neurological diseases dlvr.it/TS9YvF

Great talk by @MundAndreas at #AACR26 summarizing @CD_AACR paper. - 5000+ proteins from only 50-100 microdissected cells - key differences between incidental & cancer adjacent precursor lesions - identifying KRAS allelic mutations via mass spec, validating polyclonality

📢Preprint: Positional information (PI) and information flows in dynamic tissues. Our mathematical framework quantifies, from data, how the coupled stochastic dynamics of cell positions and properties preserve, degrade and generate PI. @axplum biorxiv.org/content/10.648…

Advancing CAR T-cell strategies for solid tumors remains a key focus in IO and a recent #JITC study by Diego Salas-Benito et al explores targeting both mesothelin and MUC16. These approaches compliment new CAR T-cell therapy data presented by J.R. Choo at #AACR26. Learn more: jitc.bmj.com/content/13/9/e…

1/ Spatial transcriptomics is among the richest view of human biology that we have: 18,963 genes mapped at subcellular resolution. It's also almost never collected outside of research settings. So we trained a foundation model to generate it from a clinical H&E image alone. Meet TARIO-2. 🧵 noetik.blog/p/tario-2-a-wh…

In the latest issue! Mapping intratumor heterogeneity across layers for advancing immunotherapy dlvr.it/TS5wwr

Reliable detection of Host-Microbe Signatures in cancer using PRISM dlvr.it/TS47zh

がん研究の世界では大御所中の大御所ともいえるAllan Balmainが書いた”進化のレンズを通してがんのプロモーションを考える”という総説。発がん課程について最初期の化学発癌から最近の組織モザイクまで進化の目で見通すというイメージらしい。Nature（続く） nature.com/articles/s4158…

"A mechanism for adaptive genome regulation in cancer" @Nature by @ItaiYanai nature.com/articles/s4158…

Interested in cellular learning? In this week’s Nature we propose a mechanism for cells can actually LEARN new regulatory configurations of their genes, by using the principles of combinatorics, feedback and memory. Check out the🧵⬇️! nature.com/articles/s4158…

🏆 Honoring a pioneer in cancer research James P. Allison, PhD, receives the 2026 @AACR Lifetime Achievement Award for discoveries that led to CTLA-4 checkpoint inhibition, transforming #cancercare. Read here: ascopost.com/news/april-202…

Generative AI to deconvolute the complexity of cancer @CellCellPress cell.com/cell/fulltext/…

Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers | Nature nature.com/articles/s4158…

In the latest issue! Hallmarks of cancer—Then and now, and beyond dlvr.it/TS4Plc

Now online! Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition dlvr.it/TS3R9B

Implications for protecting against cognitive impairment following #HeadInjury👇 doi.org/10.1172/JCI199… Here, Tao Li @taoli Michael T. Heneka @michael_heneka Sergio Castro-Gomez @CastroGomezSerg & team find the inflammasome adaptor ASC drives long-lasting brain inflammation and cognitive problems after mild head injury in a closed-head injury model. The figure shows skeletonized activated microglia (Iba1+ cells) following closed head injury, with mice lacking ASC show showing preservation of morphological features, particularly at later time points.

Planetary biology has made its stage entrances across cell and molecular biology, biochemistry and biophysics. A nascent group of researchers sees planetary health as an urgent reason to bridge the molecular and planetary scales. @metricausa investigates. nature.com/articles/s4159…

For scaling-laws aficionados (I am one), here are the graphs showing power-law behavior for vasculature for embryos (macaque, mouse, turtle). This means that the vasculature of developing embryos is a scale-free fractal. More here: biorxiv.org/content/10.648…