Yiling Li 李怡灵

Excited to share our latest work uncovering TGIF2 as a key transcription factor (TF) safeguarding neural stem cell (NSC) fate and regulating neurogenic priming! 🧠 🔗 biorxiv.org/content/10.110… Here’s how we found it and why it’s important!🧵👇

@NeuralGrndState Yes! That’s why we are excited to see it plays a somewhat different role in the context of neurogenesis.

And it promotes cancer, of course.

6/ These findings establish TGIF2 as a major regulator of NSC fate, integrating transcriptional repression with lineage priming to fine-tune neurogenesis. Looking forward to discussions and feedback! 🔬💡

5/ Importantly, TGIF2 is not just a repressor of differentiation—it plays an active role in neurogenic priming. By keeping neurogenic priming genes at low levels to keep NSCs poised but undifferentiated, ensuring proper lineage priming.

Excited to share our latest work uncovering TGIF2 as a key transcription factor (TF) safeguarding neural stem cell (NSC) fate and regulating neurogenic priming! 🧠 🔗 biorxiv.org/content/10.110… Here’s how we found it and why it’s important!🧵👇

This is ‘Emotions on the Playground' by Oscar, age 5. Oscar says “No one would play with me on the adventure playground.” Please can we show Oscar that he's a superstar and his painting is absolutely magical💥 #RAYoungArtists

Very happy that our new paper from the Götz lab is out today in @ScienceMagazine! We profiled the centrosome proteome of human iPSC-derived neural stem cells and neurons and uncovered high heterogeneity with relevance for development and disease. science.org/doi/10.1126/sc…

🎉 Happy to share our latest work! Congratulations for the fantastic achievement @fanny_lepiemme ⁦@CarlaGSilva1⁩ ⁦@miriam_jt⁩ ⁦@StouffletJ⁩ with help from ⁦@MazzuGabi⁩ science.org/doi/10.1126/sc…

Great opportunity to join our team (@FrattaLab) working on an innovative new gene therapy for ALS/FTD. A mix of novel computational (incl. new machine-learning approaches), molecular & cellular biology, all with a real therapeutic aim. Get involved! Link: tinyurl.com/bddjtjvc

We are very excited to announce scverse (scverse.org), a new consortium around the core Python packages for single-cell omics data analysis. scverse is a cross-lab effort to ensure the longevity and interoperability of the single-cell analysis ecosystem in Python.

@ilFerrinho Best of luck and success!

I've just been notified that I've come through the preselection process of The LaCaixa Foundation fellowship for postgraduate students. Let's go for the interview now! Fingers crossed🤞

Three recent manuscripts reporting multimodal (RNA+protein) extensions of spatial transcriptomics! 1. SM-omics (@mssanjavickovic) : nature.com/articles/s4146… 2. SPOTS (@landau_lab): biorxiv.org/content/10.110… 3. Spatial-CITE-seq (@RongFan8): biorxiv.org/content/10.110…

This week’s podcast has a late contender for my story of the year: human brain cells, wired into the Matrix, playing Pong 🤯 (by @mjflepage) podcasts.apple.com/gb/podcast/new…

The list of speakers is incredible 🤯😶‍🌫️

Enormously proud of the result of this amazing collaboration with @am_chakrabarti, @fcylee, @luslab, @ShorterLab, @Nicolas_Fawzi and @PataniLab on how TDP-43 condensation specifies RNA binding and regulation now published in @CellCellPress authors.elsevier.com/sd/article/S00…

We are proud to share our paper with a comprehensive single cell RNA-seq, ATAC-seq and spatial atlas of the developing mouse neocortex, led by @DanielaJDiBella from the @ArlottaLab and @ehshabibi from Aviv Regev’s lab. nature.com/articles/s4158…