Brian Hodge
606 posts

Brian Hodge
@Brian_Hodge_
Aging drug discovery @UCSF Previous @BuckInstitute @UKYCMB Also interested in sk. muscle, proteostasis, bio-image analysis, comp bio
San Francisco, CA Katılım Ocak 2020
2K Takip Edilen1.3K Takipçiler

@Brian_Hodge_ i did ! keeping those UK Physiology traditions alive ...
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@MartyMcRide I went to college with Kelli. She’s one of the nicest people I know. Feel so bad for what she is going through right now
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Brian Hodge retweetledi

Title: Advice for a young investigator in the first and last days of the Anthropocene
Abstract: Within just a few years, it is likely that we will create AI systems that outperform the best humans on all intellectual tasks. This will have implications for your research and career! I will give practical advice, and concrete criteria to consider, when choosing research projects, and making professional decisions, in these last few years before AGI.
This is my current go-to academic talk. It's mostly targeted at early career scientists. It gets diverse and strong reactions. Let's try it here. Posting slides with speaker notes...
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The title is a play on a very opinionated and pragmatic book by the nobel prize winner ramon y cajal, who is one of the founders of modern neuroscience.
To get you in the right mindset, on the right we have a plot of GDP vs time.
That is you, standing precariously on the top of that curve.
You are thinking to yourself -- I live in a pretty normal world.
Some things are going to change, but the future is going to look mostly like a linear extrapolation of the present.
And the plot should suggest that this may not be the right perspective on the future.
This plot by the way looks surprisingly similar even if you plot it on a log scale. We didn't stabilize on our current rate of growth until around 1950.

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Brian Hodge retweetledi

High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs: nature.com/articles/s4155…
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We show a novel role for glycogen in neurons in protection against dementia. Glycogen accumulation is seen in fly, iPSC and human post mortem samples of Alzheimer’s disease. Breaking down glycogen rescues tauopathy by reducing ROS by enhancing PPP. nature.com/articles/s4225…
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We are super excited about our lab's first manuscript & being selected for the cover of the issue! We found that when clocks of host, parasite and mosquito align, transmission⬆️. Major congrats Ines, @BriannaPar7 and Rushlenne!
@UCBerkeleySPH
@berkeleyMCB
@NatureMicrobiol
Nature Microbiology@NatureMicrobiol
This is our April issue, oh yeah... 🐦H5N1 antiviral outcomes 💊Abx against N. gonorrhoeae 🌱P. syringae plant infection 🦟Circadian rhythms in malaria ...and more 👇 nature.com/nmicrobiol/vol…
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@FitFounder 8h sleep, carbs around workouts, large breakfast, no booze, 4x weights, 2x cardio, dinner before 6pm, minimize eating out, no calorie counting but awareness of intake to match output
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10 years post-PhD and finally…the promotion and tenure pour. Shout out to all my mentors, collaborators, colleagues, and trainees. Science is a team sport, and my team is all MVPs. #myotwitter

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Announcing the 6 finalist for the Advances in Skeletal Muscle Biology Conference Trainee Communication Award! Vote for your favorite video and the trainee with the most likes wins! @MYOTWlTTER
#4 of 6: Ross Wohlgemuth
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Brian Hodge retweetledi

Five years of work, one big question: Which has a greater impact on aging—our environment or our genes? I'm excited to share our paper published today in Nature Medicine, demonstrating the major role of the #exposome in shaping mortality and #aging. nature.com/articles/s4159…
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Brian Hodge retweetledi

A common misconception:
‘To get a PhD, I need to be really smart.’
Nope. You just have to be genuinely curious.
I often hear students say they're afraid of a PhD because they feel 'not good enough' for it.
My experience is:
- You don’t need extraordinary skills to earn a PhD
- You don’t need to be a ‘walking encyclopedia’
- You don’t need to be a genius
❗ All you need is curiosity.
The curiosity that brings joy in exploring intricate technical details.
- Hard work is a by-product of curiosity.
- Exploration of literature is a by-product of curiosity.
- Your own vision for the field is also a by-product of curiosity!
The problem is that:
- There are advisors who likes ‘active doers', not ‘curious thinkers'
- There are bad & boring projects that misalign with natural curiosity
- There is a lack of mentorship that fails to nurture curiosity
Of course, all students are different:
Some PhD students are fast thinkers, others are fast learners or deep thinkers. Some require re-learning. Others need proper mentorship in their first year.
❗But there is NO fundamental flaws that should prevent 99% of students from getting a PhD.
PhD is just a degree.
You are ready for it if you feel curious.

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Brian Hodge retweetledi

Our latest paper is out! In collaboration with @DrAnneCarpenter, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/…
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Brian Hodge retweetledi

Congrats @kaesser & colleagues for their new @JCI_insight paper: Targeted Bmal1 restoration in muscle prolongs lifespan with systemic health effects in aging model. tinyurl.com/crs27vna
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Alzheimer’s disease aka Type 3 diabetes
Lamming Lab@LammingLab
Glad to announce the publication of graduate student @mmsonsalla's paper, "Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease"! link.springer.com/article/10.100…
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