Francesca Lorenzin

Favorite study! Germline-somatic tandems dictate cancer subtypes, provide clinical insights, and fuel molecularly informed studies. Kudos: Blerta Stringa, @Paola_Gasperini, Alessandro Alaimo, and @LunardiLabCIBIO (co-last a!) @NimaSharifiMD doi.org/10.1158/2159-8… @UniTrento

❗️Excited to share my PhD work in Genome Biology: PRODE recovers essential and context-essential genes through neighborhood-informed scores. What is PRODE, and how does it help?👇

How can we make PARP inhibitors more effective in castration-resistant prostate cancer? @FrancescaBZNY et al. identify the DNA repair gene LIG1 as a sensitizer to PARP inhibitors in multiple tumor models: jci.org/articles/view/… @FraLo05 @GiuliaFracassi_ @CIBIO_UniTrento @AIRC_it @PCF_Science @ERC_Research

Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Check it out here: doi.org/10.1093/nar/gk…. Big thanks to collaborators @erhard_lab, @MYCGyvers and AG Schlosser!

Proud of our LIG1 loss/PARP inhibition #SL study in @jclinicalinvest by @GiuliaFracassi_ an @AIRC_it fellowship awardee and @FraLo05 a @PCF_Science YIA Collaborators: @quimmateo @FdAdF66 Relevant to #prostatecancer and beyond. Download it! jci.org/articles/view/…

🚨 New Preprint Alert! 🚨 I’m thrilled to share our latest study now online on JCI: 
CRISPR/Cas9 screens identify LIG1 as a sensitizer of PARP inhibitors in castration-resistant prostate cancer. 🔬 Check out the preprint here: doi.org/10.1172/JCI179… Huge thanks to @FrancescaBZNY, @FraLo05, all Demichelis’ lab members and facilities staff at @UniTrento @CIBIO_UniTrento, and key collaborators @quimmateo, @FdAdF66 and Helmut Klocker. Special thanks to Fondazione Trentina per la Ricerca sui Tumori, @AIRC_it fellowship, @ERC_Research, @PCF_Science, and MIUR. #ProstateCancer #CRPC #LIG1 #PARPi #Biomarker #SyntheticLethality #PrecisionMedicine

🔥Post-doc position open🔥 at the Demichelis laboratory @UniTrento ⏳ application by August 31st! 👉 more info evitasociety.org/index.php/atti… #oncosome #prostatecancer #evitians @CaterinaNardel1 @FrancescaBZNY

I had the honor of writing a preview of the article published by @ICasanovaSalas et al. in the latest issue of @Cancer_Cell . doi.org/10.1016/j.ccel…

The recipient of @embojournal Molecular Medicine poster prize is: Fracassi Giulia @GiuliaFracassi_ @CIBIO_UniTrento @UniTrento

Happy to share our recent publication on #TERRA participating in #telomerase regulation at human #telomeres. science.org/doi/10.1126/sc…. Great work from @Bettinnicole_ and coworkers in collaboration with Chartrand lab @UMontreal. @ScienceAdvances @AIRC_it @CIBIO_UniTrento @UniTrento

We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!

Interested in the interplay between human #genetics and the #microbiome ? Nice opportunity for a #PhD position in my lab at @CIBIO_UniTrento in collaboration with @asnicar and @nsegata at @cibiocm Check for scholarship 1C here: unitn.it/en/ateneo/1961… deadline 17th June

CIBIO is hosting Titia De Lange from @RockefellerUniv winner of the 2024 @pezcoller @aacr Award for the Pezcoller Lecture: Telomeres and #Cancer: Tumor Suppression and Genome Instability 🗓️ May 10th, 2.30 p.m. 🏦 Sala Stringa, FBK ℹ️ webmagazine.unitn.it/node/120501/ #CIBIO

The department has launched a call to fill a tenure-track assistant professor position in molecular biology (RTT, BIO/11). Send your applications in! 📅 May 16th, 12.00 ➡️ Apply here: lavoraconnoi.unitn.it/bando-dr-valco… #ScienceJobs #research

Have you ever wondered if transcription elongation could influence tumor immune evasion? Happy to share results from my PhD work @MYCGyvers @Uni_WUE published @NatureComms. Check it out nature.com/articles/s4146… #MYC #PAF1c #PDAC #immune_evasion #PDAC 1/2

A couple of years ago Andi @villunger and I suspected that extra centrosomes kill blood cells via Caspase-2. Problem was: ko of candidate substrates had no phenotype. Now @dario_rizz and @VincenzaVigo figured out why dlvr.it/T2lg8S

Surprising mechanism revealed by androgen-independent PSA spikes in chronic prostate inflammation: EV-delivered TRPM8 mRNA promotes TLR3 & NF-kB signaling, and antitumorigenic sterile inflammation @AlessandroAlai7 @LunardiLabCIBIO et al @CIBIO_UniTrento embopress.org/doi/full/10.10…

ANNOUNCEMENT: RFA for 2024 @PCFnews Young Investigator Award Applications, to support innovative & highly promising early career #ProstateCancer researchers. DEADLINE: 4/15/24 Application Portal opens 1/29/24 pcf.smartsimple.com View the RFA here: res.cloudinary.com/pcf/images/v17…

I am beyond excited to see our work out in @CD_AACR . We established a targeted sequencing assay to non-invasively monitor treatment resistance in advanced prostate cancer. Want to know more? Let’s take a short walk 👣 aacrjournals.org/cancerdiscover…

Noninvasive detection of NEPC by targeted cfDNA methylation @CD_AACR co-led by @FrancescaBZNY and her lab @UniTrento. Congrats to first author @GMFranceschini and thank you to many amazing collaborators @PCF_Science @DanaFarber_GU #NEMO aacrjournals.org/cancerdiscover…