Quentin Frenger

My first postdoc preprint is out! Upon starvation, the Vimentin IFs network rapidly compacts (in <15 min!) to "cage" ER-Endosome membrane contact sites. This spatial confinement is crucial for autophagosome biogenesis. biorxiv.org/content/10.648…

Anthropic tests Claude Operon for scientific research in biology Operon is a new Claude desktop app mode designed for biology and health research, featuring dedicated project tools and session management. testingcatalog.com/anthropic-test…

NimbusImage: a cloud computing platform for image analysis. nature.com/articles/s4159…

Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation biorxiv.org/content/10.648…

Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation biorxiv.org/content/10.648… #biorxiv_cellbio

Big thanks to Etienne Morel and all the MEMBRAMICS lab! @MEMBRAMICS_lab

My first postdoc preprint is out! Upon starvation, the Vimentin IFs network rapidly compacts (in <15 min!) to "cage" ER-Endosome membrane contact sites. This spatial confinement is crucial for autophagosome biogenesis. biorxiv.org/content/10.648…

LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses | bioRxiv biorxiv.org/content/10.110…

As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells. #immunology #science #tumor #immunotherapy nature.com/articles/s4158…

What a beautiful time at the European Intermediate Filament Meeting 2025 in Lyon! I was so glad to meet such a welcoming community. I'm honored to have won the Best Oral Communication Prize for my recent postdoc project on Vimentin and Autophagy! Huge thanks to the organizers!

ATG16L1 controls mammalian vacuolar proton ATPase rupress.org/jcb/article-ab…

Lysosomal vacuolation has been observed for decades in many diseases. Today in @ScienceMagazine, we report LYVAC/PDZD8-mediated directional, ER-to-lysosome lipid transfer as an essential mechanism for lysosomal vacuolation. science.org/doi/10.1126/sc…

New Online! Lysosomal membrane homeostasis and its importance in physiology and disease bit.ly/4laCUDu

Borisyuk, Kaganovich, Amen et al. (@EPFL_en @unisouthampton) show that PKC promotes peroxisome-ER interactions and #peroxisome formation. hubs.la/Q03y2Cm30 ▶️ See video summary of the study by Howman: hubs.la/Q03y2Gk20 #ER_literature

.@LabYuseff @uc_chile show that B cells respond to mechanical cues at the immune synapse through ATAT1-dependent microtubule acetylation to coordinate cytoskeletal dynamics & lysosome positioning, enhancing antigen extraction and presentation hubs.la/Q03y2G-f0

Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell cell.com/cell/fulltext/…

Excited to share our latest review "Lysosomal Repair in Health and Disease". We summarized how cells repair lysosomal damage via 4 distinct strategies and discussed the implications for aging, neurodegeneration, cancer, infection, and more. Open access: onlinelibrary.wiley.com/doi/10.1002/jc…

Rab GTPases are evolutionarily conserved signals mediating selective autophagy rupress.org/jcb/article-ab…

Celldetective: an AI-enhanced image analysis tool for unravelling dynamic cell interactions. elifesciences.org/reviewed-prepr…

🗓️ Join us on Friday, March 28, for a #seminar with Dr. @GoetzJacky (@CRBS_Strasbourg) on "Multi-modal tracking of metastasis: from priming to inhibitory targets." 🔍 A great chance to dive into new insights on cancer metastasis. @MEMBRAMICS_lab

Vimentin filament transport and organization revealed by single-particle tracking and 3D FIB-SEM rupress.org/jcb/article-ab…