Shuhei Fujima 藤間秀平

Our latest study, “Parvalbumin interneurons in the insular cortex control social familiarity and emotion recognition “, has just been published in Cell Reports. doi.org/10.1016/j.celr…

Science Reward magnitude determines reinforcement learning efficiency This study shows that larger rewards can dramatically accelerate learning in mice. Across multiple behavioral tasks, bigger rewards increased task engagement and improved both within-session and across-session learning. The researchers also found that larger rewards produced stronger and longer-lasting dopamine release in the ventral striatum. Using optogenetics, they showed that enhancing dopamine signaling could partially reproduce the learning benefits of large rewards. Overall, the paper suggests that reinforcement learning efficiency depends strongly on reward magnitude and dopamine dynamics, not just the number of training trials. science.org/doi/10.1126/sc…

2026年のNatureの論文 Kurita G, Adachi KA, Uesaka K, Goshima G. Genetic switch between unicellularity and multicellularity in marine yeasts. Nature. 2026 Feb;650(8103):909-919. nature.com/articles/s4158…

オプトとかで緑色使ったらそれだけで影響あるってこと？

Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice. pubmed.ncbi.nlm.nih.gov/40267134/

An oxytocin-gated circuit from the hypothalamus silences olfactory tubercle neurons to drive prosocial grooming biorxiv.org/content/10.648… #biorxiv_neursci

In the latest issue! A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation dlvr.it/TSdqZz

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s4158… led by @Dorie00 & @yingchen733

Oxytocin Neuron‐Specific CAPS2 Deficiency in Mice Impairs Hippocampal Plasticity and Long‐Term Memory Through Reduced ERK Phosphorylation in the Ventral hippocampus onlinelibrary.wiley.com/doi/10.1111/ej…

Happy to share our new review on Neural Mechanisms of Social Hierarchy across Species. We discussed how different individuals in various species, from fish to humans, achieve high social status and the neural circuits supporting each of those strategies. nature.com/articles/s4158…

【英語でのプレスリリース】 データ駆動的に神経配線ルールを推定する手法「SPERRFY」を開発。 実際、マウス脳データで、遺伝子発現情報のみから神経配線を予測することに成功。 小池二元くん（元広大学生；現在、学振PD＠福井大学）の研究です。

血圧、fMRI、EEG、瞳孔、カルシウムイメージングなどを統合して全身麻酔後の意識回復を解析したプレプリント。意識回復は「反射回復→意識レベル回復→意識内容回復」のような段階的プロセスとして進行することを示していて興味深い。 biorxiv.org/content/10.648…

熱を加えると宙に浮かぶこの物体。本物です。フェイク動画ではありません！ 空気より0.5～10倍軽い機能素材を 工学研究科の上野智永助教が開発しました。 ベンチャーを立ち上げ、次世代モビリティや航空宇宙分野での実用化を目指しています。 #名古屋大学 #ソラマテリアル

Online now: A circuit-based framework for depression: Reshaping the pathological attractor dlvr.it/TSNZBN

タコってイオンチャネル型のドーパミン受容体を持ってるんや！😳そんな動物がいるとは知らんかった... nature.com/articles/d4158…

Online now: Dentate gyrus interneurons modulate winner-take-all network dynamics in freely behaving mice dlvr.it/TS7cV7

Neuron Risk reshapes amygdala representation of choice cell.com/neuron/fulltex…

What has changed in mama bear brain (well, actually mice) to make her risk her life to attack a potential threat and protect her young? Oxytocin is the key! Happy to share our new study led by two awesome postdocs: Takashi Yamaguchi and Rongzhen Yan. nature.com/articles/s4158…

Microglia respond to and induce anxiety and grooming in mice using calcium signaling nature.com/articles/s4138…

A miniaturized ultrasound enables targeted stimulation of subregions throughout the #brain, increasing the types of tools and opportunities for studying brain function. scim.ag/4vmI7hL

遺伝的に同じマウス３匹を一緒に生活させると、メスは協力的なグループができるけれど、オスはギバーとテイカーに分かれてしまい、その原因が脳のVTAのドパミンの違いが影響していたという論文 Dopaminergic mechanisms of dynamical social specialization. #Nature doi.org/10.1038/s41586…