Grandma's NeuraLink👵🏽🧠⏲

These are 2 photogtra photographs of my grandson @elonmusk and, Sometimes, when he's bored, he goes by @BoredElonMusk . He is living on mars now. I am so proud of him

@bryan_johnson Underlying your ethos are some fundamental inconsistencies that I think are best summarized in your own words, from "We The People" and "Dont Die." Blueprint is more of a tic disorder than an actual structured plan for humanity, and your books make that rather clear.

Last year I nearly shut down Blueprint. My reasoning was that in the grand game of existence, getting our societal goals right is the only thing that matters. In the long arc of time, it wouldn't matter if I built a longevity company. I wanted to invest all of my energy into Don't Die. Maybe I'm naive, however it seems obvious to me that when your species is giving birth to superintelligence, your sole concern becomes survival. Not because you're scared or fear what may come, but because you realize that superintelligence is big. Bigger than any of us can imagine and happening faster than our intuitions allow us to model. This is a hard concept for Homo sapiens to understand because we are not good at understanding our limitations of knowing. In the void of not knowing, the one thing that we each know to be true is that none of us want to die right now. When tomorrow arrives, that will be true about the next day too. Don't Die is not about immortality. It's about the most basic observation of intelligent life, we want one more breath. Just as Homo erectus, a million years ago, with an axe in their hand, was unable to articulate our modern world, we are once again Homo erectus relative to AI. We may experience a million years of relative progress in the next 10, 20 or 50 years. Given this, Kate and I have cycled through this problem hundreds of times over the past few years. How can we get the world aligned around Don't Die? Committed to the idea that in spite of our many differences, we share a planet and a common interest in tomorrow. Basically, how can we make existence profitable and die unprofitable. We saw the problem as two-fold. One practical and one spiritual. Practically, we need things to work in the world: clean water, transportation, energy, security, stable institutions, communications and health care. Spiritually, we need purpose, existential explanations, and hope. We also need progress and adventure: solve aging, abundant AI, creative joy and expression and things to build. We decided to build on both fronts. Blueprint would be the practical, a company aligned to Don't Die. A group of humans that labor together to help other humans thrive as their sole objective. To hold ourselves to a standard of making existence profitable and die unprofitable, for ourselves. To never let profit corrupt this goal. Sounds simple until you take stock of how many companies make their living on making humans die. Sometimes this is done openly and other times it's hidden in a mesh of poorly aligned incentives that are invisible. This is not an esoteric philosophical argument, death is measurable in a biological system. You can get clever and find arguments ("does this mean we shouldn't have children?") but we know death and life when we see it. On the spiritual side, we think that 2027-28 is the breakout time for Don't Die. Maybe we're off by a year or two, but we think it's soon. We believe that AI will create several societal shocks, none of which we will predict accurately, but will leave the world feeling unmoored. Hopefully it won't be catastrophic, but will be a cold water dunk we need to awaken us to the realization that no one really wants to die right now and that our current societal systems that profits from death are ill suited for this moment. That in our most sober moments, when at funerals, or after a near-death experience, we see clearly, even if for a few minutes. Above all, we care about life more than anything else. All else fades away in those moments. We see with crystal clarity that all the other stuff that had us entranced wasn't that important after all. I write this for two reasons. First, to invite you to build Don't Die in the practical world. Capitalism (profit and loss) is a good system that has done society well. In whatever you're building, align your and your organization's efforts with a loyalty to acting in people's best long term interests. Don't do things that cause other people to die, commit self harm, or create societal harm. This doesn't mean being paternalistic, it means using your best judgement about how you'd want someone else to treat you if the roles were reversed. Second, to ready yourself for the new philosophy that will be arriving shortly. One that prioritizes our shared existence and vitality above all other goals. Don’t Die is the foundation. Immortalism is what we’re going to build. Again, not for selfish reasons, but because we understand that we are warriors and caretakers of intelligent life in this part of the galaxy and we take on this responsibility with honor and nobility.

@bryan_johnson @bryan_johnson 5 years and counting of you tacitly approving of your wealthy buddies destroying Medicare

This is it. Everything learned spending millions on longevity. From: Your Immortal Unc and Auntie. To: Our Immortal nieces and nephews. 0. Sleep is the world's most powerful drug. 1. Be in your bed for 8 hours 2. Same bedtime every night, any time before midnight 3. Don’t eat right before bed 4. Calm foods for dinner 5. No screens 1 hour before bed 6. Avoid added sugar (be aware it’s in everything) 7. Avoid all things in an American convenience store 8. Avoid fried foods 9. Shoes off at the door 10. Eat whole foods, particularly veggies fruits nuts legumes berries 11. Walk a little after meals or air squats 12. Get your heart rate high routinely 13. Lift heavy things 14. Stretch daily 15. Water pik, floss, brush, tongue scrape, morning and night 16. Make an effort to drink water 17. Get sunlight when you wake up (UV is low) 18. Protect skin in midday sun 19. Stand up straight 20. See at least one friend once a week 21. Avoid plastic where you can (in all things) 22. Circulate air in rooms 23. When stressed, breathe, learn to calm your body 24. Go to the dentist 25. Avoid sitting for long times 26. Protect your hearing, the world is too loud 27. Alcohol is bad for you 28. Finish coffee before noon 29. Avoid bright lights after sunset 30. If obese, look into a GLP 31. Sleep in a cold room 32. Texting while driving is dangerous 33. Turn off all notifications 34. Limit social media use 35. Don’t smoke anything 36. If you struggle to sleep, read a physical book before bed 37. 1 hour before bed have a calm wind down routine: bath, read, light walk, listen to music 38. The body is a clock and loves routine. Have a daily morning and evening schedule. 39. Avoid long distance travel where you can 40. Baby steps first: incorporate new things slowly 41. Do less… most things don’t work. Bonus points if you get your blood checked. Start here, it will change your life.

@elonmusk @elonmusk Elon "Daniel "I abandoned my child" Plainview" Musk

If they’re willing to die to assassinate, imagine what they will do if they gain political power

@bryan_johnson *i read them both.

@bryan_johnson @bryan_johnson Feels like speedrunning orthorexia at this point. Not challenging your intentions, just your state of mind. "Don't Die" and "We The People" sit here next to me, read them both.

This pill camera traveled my intestinal tract for 10 hrs and 38 min, taking 33,537 images. Looking for lymphoma, Crohn's ulcerations, small bowel cancer, diverticula, and polyps. Nothing found. This was Jan 2022. Bidirectional endoscopy next week. Upper and lower.

@bryan_johnson @bryan_johnson Your addiction to medical interventions is so evolved that you now lack statistical power to evaluate any of your own claims. Blueprint destroyed itself.

Just spent over an hour with my clinical team debating which growth hormone peptide protocol to run. Still torn. Wanted to share the thinking and get your take. The goal: Increase GH and IGF-1 to support anabolism, recovery, and sleep, but also test a specific stacking hypothesis. Tirzepatide (GLP-1/GIP agonist) can elevate resting heart rate, disrupt sleep, and suppress appetite aggressively. CJC-1295 (GHRH analog) can worsen insulin resistance. The bet is that combining them cancels each other's downsides: CJC-1295's slow-wave sleep enhancement offsets tirzepatide's sleep disruption, while tirzepatide's insulin-sensitizing effects counteract CJC-1295's insulin resistance. Best of both worlds — or at least, that's the hypothesis we're testing. The two candidates: CJC-1295 with DAC: the long acting version. One injection per week, stays active for 6–8 days. This is what was used in the actual clinical trials. Raises GH 2–10x and IGF-1 1.5–3x from a single dose. Preserves GH pulsatility even under continuous stimulation. The tradeoff: if you get side effects, you're committed for a week. Harder to titrate. CJC-1295 without DAC + ipamorelin: the short-acting version paired with a selective ghrelin receptor agonist. Daily injections, pre-bed, clears in 30 minutes. Ipamorelin adds a second axis of GH release, pulse frequency via the ghrelin pathway, on top of the amplitude boost from CJC. No cortisol or prolactin elevation. This is what most clinicians prescribe and most of the peptide community uses. The tradeoff: less clinical trial data, daily injections, more anecdotal evidence base. What we're considering: Start with DAC at half dose 2.4 mg, then if well tolerated escalate 4.8 mg, weekly injection. If side effects aren't tolerable, switch to no-DAC + ipamorelin (100 mcg then 200-300 mcg daily, before bedtime). Or, Run both head to head. 2 weeks DAC, 2 weeks no-DAC + ipamorelin and compare. Tracking: GH, IGF-1, Cortisol, CGM, real time core body temperature, RHR, overnight HRV (rMSSD), IGF-1, HOMA-IR, sleep architecture, subjective recovery. The purist in us says stick with DAC; that's where the published data lives. Yet the pragmatist says no-DAC + ipamorelin is what thousands of people actually use, and testing it generates more socially relevant data.

@elonmusk @AmandaAskell Krog reporting for duty

@AmandaAskell Unfortunately, any given AI company is destined to become the opposite of its name, so Anthropic will, ironically, be Misanthropic

Claude's constitution is out! It's the culmination of a lot of work by many people, but it's also a work in progress that will no doubt change and hopefully improve over time. I'm looking forward to people's thoughts, and to talking with more people about this kind of work ❤️

Well, I think, I'm getting older. But aren't we all.

What's happening? Everyone can reply. Post (Heh!)

@bryan_johnson @bryan_johnson Respectfully, didn't you dump your wife because she developed cancer?

It may seem unthinkable...but in just a few years time, I predict that behaviors causing biological degradation such as trash food, alcohol, sleep deprivation, high stress, and sedentary living will culturally transition from acceptable to low status and insane.

@elonmusk @elonmusk So should you

Grok should have a moral constitution

@bryan_johnson @bryan_johnson A note of caution for those who "stand with Bryan," he's a nice guy and everything, but he doesn't believe healthcare is a human right, and has failed to call out christian nationalists for banning it.

A note of appreciation for those of you who stand with me. Who've taken the risk publicly or privately. I know the cost. I respect you for your intellectual sovereignty.

I must purport something that *feels obvious* to me, but maybe isn't clear to most: @ericweinstein is an intellectual whose presence at the level of mass-media punditry (bare minimum) would help America. Why is he not more prominent? Feels like an amorphous-yet-real shadow-ban.

@bryan_johnson @bryan_johnson I stayed up late being defeated by the Christian Nationalists who have deleted universal healthcare from our country's collective past, present, and future.

If you're in need of confession to cleanse your soul from last night's activities, I am here and ready to receive.

@elonmusk @elonmusk What about the Epstein stuff? Genuinely asking.

America is toast if the radical left wins. They will open the floodgates to illegal immigration and fraud. Won’t be America anymore.

I may be old but, I know, genius when I see it.... and wow, YouTube taught me about, @styropyro_ . Madlad. I wrote a short story today it's a vengeance story about a nerd getting back at his bullies using electricity and, I've decided, it should be a movie starring Styro Pyro.

@elonmusk Still wondering @elonmusk

The situation w/recreational drones in the U.S. is really sad. Wish we had a manufacturer that could compete w/DJI. @elonmusk ever thought about making drones for consumer/pro use here in America? Forgive me if it’s a dumb question. I’m not the brightest crayon in the shed

Interesting points

@bryan_johnson This is a very complicated eating disorder. People forget that anorexia and orthorexia can affect everyone, Silicon Valley tech entrepreneurs included 😔 @bryan_johnson

Talmage’s bike took flight, stunning his friends. He flew one lap around the school and landed safely by the jungle gym.  Jasper approached and fist-pumped “respect Talmage for not giving up.” My six-year-old son is tucked into bed, his eyes are lit up. These stories feel real to him. Every night we do this. He tells me about his day and then I make up a story with him as the protagonist. In them, he invents, overcomes hardship, deals with difficult relationships, and learns. We navigate the world together through story. I tuck him in and kiss him good night. As I leave his room and head into the family room, my heart sinks. My partner is there on the couch waiting for me. She’s upset and wants to talk. I don’t. We’ve had this same fight, I don’t even know how many times. It feels like insanity to me. I’m still reeling from the stress of the day. It was warfare. I’m the founder of a payments company; the battle never ends. My depression is raging. I am numb to existence. I’m overweight, inflamed, sleep deprived, and feel no hope for anything. We recite the same words, and resolve nothing. I want to be an opossum and play dead. It’s too much. The brownies. There’s a pan in the kitchen. Imagining eating them drips dopamine in my brain, giving me momentary reprieve from the pain of life. As I walk into the kitchen, I decide on one bite only. I can’t overeat again. The top button on my pants can’t be buttoned and it drives me crazy. I refuse to surrender and buy bigger pants. One bite becomes half the pan. The brownies win again. I now feel sick. I’ve repeated this situation, what, hundreds of times? Why do I do this to myself? The situation is absurd. My hands never disobey. My mind, however, a masterpiece of evolution, disobeys itself to commit self harm. How do I negotiate with this malfunction? I spend my day building software. We define an objective, write lines of code, and the software does what it’s instructed to do. Reliably. Yes, there are bugs and the software needs some upkeep, but it doesn’t steal away and act on runaway impulse.  Why can’t I build myself like software? Not to perfect but to author. It feels like such a catastrophic waste of my intelligent existence to be enslaved to impulse. My brain has 86 billion neurons and 100 trillion synaptic connections. My body is an elegant orchestra of over 30 trillion cells. Surely this precious gift can be used for more virtuous purposes. It must. Otherwise how will humans survive in the age of AI?  I mean, if we look all the way back, what is intelligent existence if not the continuous scaffolding and automation to higher levels of complexity. Fire freed our ancestors from certain caloric and dietary restrictions, which opened up energy (metabolism and time) for things like language and society to develop. Hand stitch to loom. Wagons to horses to the combustion engine. Abacus to computers. Whitehead captured it: “Civilization advances by extending the number of important operations which we can perform without thinking about them.” Could I reframe that and apply it to myself? Bryan Johnson advances by extending…. I need protection from threats too. The brownies are the enemy. They are a civilization that eats itself. I’m vulnerable because these addiction patterns found their way into my biology at a young age. Sugar cereals, sugar soda, and highly processed foods. What strength do I have to fight with? Will power is fickle. What if I could enable my heart, liver and lungs to speak, allowing them to provide status updates and express their needs. Then what if those needs could be automatically addressed by other systems including nutrition, exercise, sleep, medications and therapies. The technology isn’t there yet for this to be fully automated. But maybe I could build an analog system. In the future, maybe this system will run autonomously. People will hear this and surely say that we humans are not machines. We are living, breathing, chaotic, emergent systems of intelligence and this would sack the joy out of life. I understand that perspective. Also, maybe that’s a story we tell ourselves. We’re already more automation than decision. We exist because and thanks to automation. Digestion, wound healing, our immune systems. Our bodies run without our consent. Most of our thoughts and emotions are pre-programmed. What exactly is one holding onto? Wouldn’t this be the ultimate realization of freedom and transcendence? Interrupting the philosophical considerations, practicality begs our attention. With AI, we must adapt and evolve or fade into fossils. Automation is our near-term destiny. Why not lean into it? But what will we become? That’s the existential question every generation born of technology gets to ask. I’m curious and want to explore.  I’m going to build this. I’ll call it my Autonomous Self.