Gideon Sarpong

By employing a virtual reality behavioral system and in vivo imaging, our new study shows how a brain chemical, acetylcholine, helps the brain learn and adapt to unexpected events, driving flexible behavior. @oistedu @NatureComms doi.org/hbf2k3

Check out our latest customer story on @Gasarpong at @OISTedu. phenosys.com/customer-stori… His work published in @NatureComms explores the role of acetylcholine (ACh) in behavioral flexibility. Read the study👉 nature.com/articles/s4146… #neuroscience #behavior #neurobiology

…which have been central to shaping this work. nature.com/articles/s4146… To everyone who has supported this journey - thank you. Looking forward to what lies ahead!!! #phenosys #virtualreality #Neuroscience #BrainResearch #Acetylcholine #BehavioralFlexibility #Learning

…collaboration with a dedicated group of colleagues and the continued support of the @PhenoSys team, whose guidance has been invaluable throughout. Grateful for the mentorship and research environment at @OISTedu…

“If I have seen further, it is by standing on the shoulders of giants.” — Isaac Newton Honored to have my work featured by @PhenoSys as part of their success story series. phenosys.com/customer-stori… This has been a truly rewarding experience, made possible through…

…collaboration with a dedicated group of colleagues and the continued support of the @PhenoSys team, whose guidance has been invaluable throughout. Grateful for the mentorship and research environment at @OISTedu…

Last week I joined the IBRO School on “Complexity in Mental Health” in Italy. As a behavioral neuroscientist at @OISTedu, it was inspiring to exchange ideas across disciplines and career stages. Huge thanks to @IBROorg for the support. #ComplexityInMentalHealth #Neuroscience

🔔A new @natcomms study from @OISTedu & @hhmi_science explores how the brain "switches" strategies. Huge congrats to the team! 🎉 nature.com/articles/s4146… We are humbled to contribute to this study through our JetBall-TFT system.👉 phenosys.com/brain-research…

🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n] nature.com/articles/s4158…

New paper alert 🚀 Our organism-wide single-cell ATAC-seq atlas of mammalian aging is now out in @ScienceMagazine, led by our fantastic graduate student @ziyu__lu from @RockefellerUniv! science.org/doi/10.1126/sc…

MOST READ PAPER (>8100 readers) in 🚀🧠 A comprehensive, timely review of psychedelic therapy in depression & substance use disorders—covering neurobiology, clinical evidence, plasticity, and ethical considerations. 🌱🧬 A must-read for the neuroscience & mental health community. @FENSorg @WileyBrainPsych @istanbuledu onlinelibrary.wiley.com/doi/10.1111/ej…

excellent new paper breaking a long-standing impasse by the identification of specific behavioral conditions under which CINs are recruited to augment DA release in vivo : Cholinergic modulation of dopamine release drives effortful behaviour nature.com/articles/s4158…

New protocol from SWC reduces off-target effects in optogenetics 🚥 Light can unintentionally activate retinal cells, complicating results. The protocol minimises light leakage and verifies off-target activity is reduced. ➡️ Paper in @STARProtocols star-protocols.cell.com/protocols/4708

Very cool preprint from Paul Kramer and Zayd Khaliq showing a dual effect of nicotinic receptors on excitability of striatal dopamine axons. Excitatory nicotinic signaling drives action potential bursting in dopaminergic axons biorxiv.org/content/10.648…

𝗪𝗵𝗮𝘁 𝗶𝘀 𝗻𝗼𝗶𝘀𝗲 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻? Almost always we average responses thus equating response variability with noise. Well, we shouldn't because variability is also signal, not noise to be entirely discarded. doi.org/10.1016/j.neur…

Join leading scientists for a 3.5-day #LakeConference discussion on: "The Neurobiology of Mental Health" at the level of genes, cell types, organoids, circuits, networks and brain systems. Learn more & apply by January 31: lakeconferences.org/conf/1ed63fdb-…

I’m very happy to share the final version of this, now published in @Nature rdcu.be/eY5nh Hippocampal neurons that initially encode reward shift their tuning over the course of days to precede or predict reward.

Tim Spellman demonstrates his open-source tool, FlexRig. Read the paper for the full instructions and parts list to build the tool. #eNeuro #OpenSourceTools doi.org/10.1523/ENEURO…

We are thrilled to share our new preprint! What happens to memory when >50% of synapses disappear? We show that artificial hibernation induces massive neuronal remodeling, yet preserves memory through protected circuit architecture. biorxiv.org/content/10.648…

脳ががっかりすると柔軟性が高まる理由 習慣を変えられない人の脳内物質 #脳 #研究/研究結果 #思考 forbesjapan.com/articles/detai…