Timothy Chan

Japanese actor Hiroyuki Sanada spoke about the contradictions of human nature: “Some people dream of having a swimming pool at home, while those who have one hardly ever use it. Those who have lost a loved one feel a profound sense of loss, while others often complain about their living relatives. Those without a partner long for one, while those who have one often don't appreciate it. The hungry would give anything for a meal, while the satiated complain about the taste of their food. Those without a car dream of owning one, while those who have a car are always looking for a better one.” The key to happiness is gratitude: truly seeing and appreciating what we already have, and understanding that somewhere, someone would give anything for what we take for granted.

This LEGO build cost him 200K and two marriages, but it’s one of the coolest things I’ve ever seen. 😳

There is only one week remaining before The Sontag Foundation Distinguished Scientist award application portal closes. Application guidelines can be found here: bit.ly/49jbcSk Additional questions? Contact Shandra Koler at skoler@sontagfoundation.org for assistance.

Pike effect🧐 Very interesting🐟🐠

Great week of our @ClevelandClinic @CCLRI Faculty Center Bootcamp on how to find an academic job; thanks to all the panelists (Apollo, Mike, Brian, Evan, Rishi) and co-organizer @longworth724 - looking forward to preparing our trainees for the next round of interviews!

@iannisaifantis1 @nyugrossman Congratulations on all you accomplished as chair! NYU has benefited tremendously from your leadership

After almost 13 years I am stepping down from the helm of the Department of Pathology @nyugrossman. It was a privilege and a pleasure to contribute to the creation of one of the most exciting Pathology Departments in the US and to work with fantastic colleagues, pathologists, research scientists, staff and trainees. During this exciting period, the department of Pathology almost tripled its faculty numbers, clinical and research (grant) revenue and invested heavily in a state-of-the-art molecular pathology lab, the growth of molecular microbiology, the expansion and automation of our clinical labs, and the integration of new digital and artificial intelligence tools that are redefining how our pathologists diagnose disease. We are now one of the few departments with ~100% slide digitization and a fully digital sign out. At the same time, the department’s research profile has increased significantly with the recruitment of leaders in the areas of immunology, cancer biology, computational science as well as world-renowned pathologists and physician-scientists. On a personal level, I was blessed to be thrown in deep water early in my life and bet on the talent and brilliance of colleagues who helped me set the foundation for a truly integrated and modern Pathology Department. I remain here to aid the transition of leadership, excited to spend more time in my own research laboratory and soon take up new challenges...@NYUGSOM_Path

A 𝐧𝐞𝐨𝐚𝐧𝐭𝐢𝐠𝐞𝐧 is a novel peptide that is derived from a somatic variant in a tumor cell and can be recognized as “nonself” by T cells. Neoantigens are tumor-specific and have not been encountered during thymic T-cell development and are therefore not subject to central tolerance. To learn more about this NEJM Illustrated Glossary term, read the Clinical Implications of Basic Research article “Understanding How Aspirin Prevents Metastasis” by Ruth E. Langley, MB, BS, PhD, and John Burn, MD, from University College London and @uniofnewcastle: nej.md/4pTzyaw Explore more terms: nej.md/glossary

Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv biorxiv.org/content/10.648… Figure 1 shows they key result

In patients with advanced solid tumors, survival improved when genomic therapy matching was based on robust clinical trial evidence; investigational or repurposed biomarker matches did not provide benefit. ja.ma/4aY8ukL

In some good news: HPV vaccines remain one of the marvels of science

Crypto Explained…

In cisplatin-ineligible patients with muscle-invasive bladder cancer, enfortumab vedotin–pembrolizumab plus surgery led to better event-free survival (74.7%, vs. 39.4%) and overall survival (79.7%, vs. 63.1%) than surgery alone at 2 years. Full phase 3 KEYNOTE-905/EV-303 trial results: nej.md/4czl8sG Editorial: Enfortumab Vedotin plus Pembrolizumab as Perioperative Therapy nej.md/4twnv5T

Wow!

@LocasaleLab Pfizer and Moderna's modRNA flu vax trials fell flat. Moderna had to halt its modRNA RSV trial because of signal of harm. Sanofi also halted its modRNA flu program. They are not magic shots, just another tool. science.org/content/articl…

@Aiims1742 @Perlmutter_CC @nyulangone @JohnPLeonardMD @nyugrossman @NYULangoneLI @NYULangoneBK @DrOscarLahoud @EmelineAvikiMD Congrats 🎊!

I am honored to serve as the new Director of the @Perlmutter_CC. Thanks to Dean/CEO Alec Kimmelman @nyulangone for this opportunity. Excited to partner with @JohnPLeonardMD & the entire PCC community as we build our next exciting chapter. Lots to come! prnewswire.com/news-releases/…

Writing is thinking. Don't let AI do it all.

Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial | Nature Medicine nature.com/articles/s4159…

scSNViz: Visualization and analysis of Cell-Specific expressed SNVs academic.oup.com/bioinformatics…

The most highly cited paper of the year is out! Cancer Statistics 2026 from @AmericanCancer in @CACancerJournal acsjournals.onlinelibrary.wiley.com/doi/10.3322/ca… "In summary, decades of scientific investment have translated to longer lives for people with even the most fatal cancers" - let's keep going!

@DrSamuelBHume Another modern miracle in our lifetime