Genius ReFi

Scientific discovery is reaching the limits of human capacity: too much data, too many disconnected fields, and too few ways to connect ideas fast enough to matter. The next breakthroughs in materials, medicine, energy, and beyond will not come from scaling today’s AI paradigm alone or from relying on serendipity alone. They will require a new kind of AI for knowledge discovery that not only models the world but shapes what it could become. At Unreasonable Labs, we are building superintelligence for knowledge discovery: systems that reason across disciplines, generate novel hypotheses, test them through simulation and experimentation, and help guide real-world discovery. Our AI engine is not confined to what it has seen in training. It creates new data, builds new tools, and maintains a persistent world model that grows more powerful as it reasons. Why now? Even today's most powerful AI models face a core limitation: they are trained on what we already know. True discovery begins when a system encounters something its current model cannot explain. This is why you cannot train your way to a discovery - a system has to reason through new problems, update its beliefs, and revise its understanding of the world as it thinks. Another critical insight is that rich knowledge already exists, but is not yet applied to solve pressing problems. It sits in millions of papers, patents, and datasets, trapped in isolated silos, often in legacy data vaults. What's missing is a way to connect it, scale it, unlock the potential, and synthesize genuine novel predictions. The time is now to build a system that enables practitioners to design, explore, and direct discovery, whether through human guidance or full automation, while capturing the tacit insight that domain experts bring. Steerable reasoning That is why we built an operating system for scientific discovery - one that replaces chance with steerable reasoning. Rather than retrieving static facts, our AI builds and continuously updates a living world model - a representation of knowledge the system can actively reason over, question, and revise. A concrete example: say you want to create "smart concrete" that can flex - a concept that doesn't exist yet. Our AI maps relationships across domains, finds a path from morphable smart materials to concrete, and identifies the most efficient way to bridge those concepts. It then autonomously writes simulations, tests the hypothesis, and refines the idea. Then it interacts with hardware to produce a physical artifact, and the loop expands into the real-world, where the machine becomes world-shaping. Our AI gives users full visibility into how the system arrived at a conclusion. It delineates which existing patents and papers it drew upon versus what is genuinely new - protecting IP and competitive concerns from the start, and offering deep compositional insights into technology advances. It takes unreasonable people to make progress Our team reflects the interdisciplinary expertise required to build this next breakthrough - my co-founder Yuan Cao @caoyuan33 (formerly DeepMind) and Andrew Lew, @HaiqianYang, Matt Insler, Jennifer Kang and Julia McLaughlin. We are backed by $13.5M in seed funding led by @PlaygroundVC with participation from @aixventures, @e14fund, and MS&AD. We are guided by advisors including Robert Langer (1,000+ patents), Kostya Novoselov (Nobel Prize in Physics), and @Thom_Wolf (Co-founder of Hugging Face). We already have multiple pilot programs underway with leading industrial partners in materials science and engineering, with additional engagements developing across energy, logistics, bioengineering, and other strategic domains. The biggest challenges of our time - fusion energy, sustainable materials, new medicines - demand exponentially more innovation than humans alone can produce. We are not replacing scientists, and instead are making every scientist capable of leading their own team of AI-powered researchers. Abundant innovation leads to abundant prosperity. Watch our launch video below to see what we're building @unreasonable_ai 👇

In this FutureCast, @NoubarAfeyan will sit down with @stripe Co-Founder & CEO @patrickc to explore the ingenuity behind bold science, new ways of funding exploration, and how technology helps turn breakthroughs into cures. Tune into the Flagship Studio during #JPM26 on January 13, 2026 at 2 PM PST/5 PM ET. Register for the livestream here: events.flagshippioneering.com/futurecastnoub… #FlagshipStudio

Inside Ignite Next: the new scaleup program supercharging Europe’s deeptech tech.eu/2025/12/10/ins…

Breaking news. Foreshadowed in the RS&T reforms of 2024 when TTOs were put on notice. NZ to unlock more science innovation. More on this shortly... geniusrefi.com/nz-unlocks-mor…

#smartbax, a #Munich-based #BioTech company developing next-generation #antibiotics against multi-drug resistant #bacteria, announced the successful first closing of its €4.7 million #preSeriesA financing round 🇩🇪🦠 eu-startups.com/2025/10/smartb…