Hill Lab

Our colleagues from Monash University and Lions Eye Institute in Australia discovered a novel stroma-based mechanism that is critical for generating effective antiviral T cell responses against cytomegalovirus. Read it now in Nature! #Sec2" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…

PTCy prevents both severe acute and chronic GVHD. In our new review published in Blood, Dr Geoffrey Hill and Dr David Curtis discuss the current landscape of GVHD prophylaxis, key unanswered questions, and what’s next in the BMT field in the PTCy era. ashpublications.org/blood/article/…

New paper out now! Led by Dr Motoko Koyama, we’ve clarified the role of various donor dendritic cell subsets in gastrointestinal acute GVHD and discuss strategies to target these populations to prevent lethal gut GVHD early after BMT. ashpublications.org/blood/article/…

New publication alert! Eomes drives differentiation of type-1 regulatory CD4 T cells that are critical for limiting immune toxicity and tumor relapse after T cell immunotherapy through dual regulatory and cytotoxic functions. Check it out! @ImmunityCP cell.com/immunity/fullt…

Eomes controls the acquisition of regulatory and cytotoxic function in CD4+ T cells that are critical for limiting immune toxicity, while maintaining persistence and tumor control after immunotherapy @ImmunityCP cell.com/immunity/fullt… @fredhutch @Geoff_Hill_Lab 🇺🇸

Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin | New England Journal of Medicine nejm.org/doi/full/10.10…

New work out of the lab! @julieboiko has identified tractable monocyte gene signatures of IL-17 and CSF1-driven chronic GVHD that can be extended to patients. ashpublications.org/blood/article-… First edition preview out now!

This open exchange between two research groups is a great example of how we can discuss papers that report what appear to be contradictory results. Long story short, the biology is actually largely the same, but the terminology and assignment of T cell subsets is different.

We have written a reply to a letter to the Editor about our recent paper looking at the effects of calcineurin inhibitors on T cell differentiation after alloBMT. doi.org/10.1172/JCI184…

I’m excited to share what has been 5 years in the making (my first project in the lab starting as a heme/onc fellow)! Microbiota dictate T cell clonal selection to augment graft-vs-host-disease following stem cell transplant. @ImmunityCP @Geoff_Hill_Lab cell.com/immunity/fullt…

New paper out of the lab! We found that calcineurin inhibitors prevented differentiation of exhausted T cells after allogeneic BMT. Rather, these T cells became memory cells and were able to cause chronic GVHD after drug removal. doi.org/10.1172/JCI170…

Treg depletion during SCM expands polyfunctional effector T cells in mobilized grafts and enhances antimyeloma immunity after ASCT. ow.ly/syjV50RjakL #transplantation #immunobiologyandimmunotherapy

For open access to our recent manuscript describing T cells that retained functional capacity despite a terminally exhausted phenotype, visit the Hill Lab webpage via the link below and scroll down to the myeloma section! research.fredhutch.org/geoff-hill/en/…

My fave postdoc project is out today!! This manuscript has been a labor of love and I'm so excited to finally share it with the broader immunology community. science.org/doi/10.1126/sc…

Next paper out of the @Geoff_Hill_Lab!! Regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation ashpublications.org/blood/article/…

Big collab between @fredhutch, @MonashUni, and @QIMRB_Institute

New paper out of the lab describing the role of endothelial cell injury and humoral immunity in CMV reactivation after transplantation. Cover art by Madeleine Flynn. jci.org/articles/view/…

When the autograft team hears the boss has a penchant for band T-shirts….