
Jonathan D. Grinstein
629 posts

Jonathan D. Grinstein
@GrinsteinJ
Scientist turned storyteller. North American Editor @inside_pm. for story leads: [email protected]


I don’t know who needs to hear this but $ABVX has already showed their cards 1. ATM was oversubscribed, essentially a sweet heart deal 2. Closed in one day (not standard) 3. The MGMT basically said they want to sell if price is right 4. If/when Crohns hits it essentially becomes too big to buy for most companies I don’t see a way forward unless it is a quick sale Reuters reported before latest data follow up multiple buyers The one holdback is - what price? This holdback is solved by one fact and one fact only Multiple bidders = FOMO Biotechs don’t sell, they get bought If you have Crohns hit it is a $10BN revenue It’s basically pay less now vs pay more later if you expect it to hit I absolutely expect one or more pharmas to bid heavily and see Crohns as a call option So what will Abivax MGMT do? You absolutely sell if you can get $220 or more a share For the sweetheart ATM that’s a 76% increase in short time There’s just too much at stake and a MGMT that imo does NOT want to launch a drug






Thrilled to release the latest episode of #Guidepost--starring Alexis Komor & Nicole Gaudelli--on the remarkable origins of Base Editing. Unquestionably the best episode so far! @CRISPRjournal @BeamTx @synthego Spotify: open.spotify.com/episode/5wihQJ… Soundcloud: soundcloud.com/guidepost/ep-1…

We asked @maxmarchione: what happens after we solve obesity? "We still have all of the things that cause aging." "We haven't really been able to slow aging. Aging is very systemic." "Even if you take the Bryan Johnson approach to aging, you maybe only add an extra 10 years to life, which is not an awful amount." "I think the kind of 10-year plus primary therapeutic modality is likely going to be genomic medicine." "If you can modify the genome, you can actually modify how DNA encodes for RNA, which produces proteins and peptides. So you can actually change the proteins and peptides your body produces by modifying DNA."


















