Guolan Lu

1/8 ✨Thrilled to share that our paper is now online @NatureBiotech “Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors” nature.com/articles/s4158… (open access): rdcu.be/fmkQp

#loaded" target="_blank" rel="nofollow noopener">inquirer.com/opinion/commen…

Antibody therapies show limited success in solid tumors. A new imaging technique developed at Stanford Medicine that locates antibodies at subcellular resolution in human tumors hints at why. brnw.ch/21x3P9B @GuolanLu #pharmacobiology

Thank you, Steven... we are very excited about the results because they show that, in real time, surgeons can use approaches like this to determine where and when tumors are being resected, and they might have "missed" a hidden metastasis just outside the margin of removal. The "margin" is the safe distance into which one must cut to statistically feel confident that all the tumor is removed. In complex cancers like head and neck cancer, the tissue is so complex (tongue, veins, muscle) that it is surgically challenging not to damage nearby structures. Techniques like those Professor Guolan Lu and our colleagues developed at Stanford enable more precise surgery as well as later analysis of where a therapeutic antibody can access, or what the cancer is doing to erect barriers that block access to therapeutic drugs. This helps us figure out what we need to do to break down such barriers.

Research from SCI members @GarryPNolan, @GuolanLu, and colleagues introduces single-cell spatial pharmacobiology, revealing how stromal barriers can limit antibody delivery and inform precision cancer therapies. brnw.ch/21x3Chr

8/8 💜 We especially thank the patients and their families for participating in the clinical trials and contributing tissue samples that made this research possible. 🏛️ We also thank our funding sources, including @theNCI, @AmericanCancer, @StanfordCancer, and @StanfordMIPS.

1/8 ✨Thrilled to share that our paper is now online @NatureBiotech “Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors” nature.com/articles/s4158… (open access): rdcu.be/fmkQp

7/8 🙏 This project has been a long journey, and I am deeply grateful to my extraordinary postdoctoral mentors @EbenRosenthal and @GarryPNolan for their guidance and support throughout this work. 🤝 And to our wonderful collaborators @johnhickey22 @Max_Haist @Loloabn @ErnaForgoMD @marc_a_baertsch @xavi_r_c @nsvdb @poultsides and many others not on Twitter/X.

6/8 💡The SSP platform is broadly applicable to antibody-based therapeutics, including immune checkpoint inhibitors, antibody-drug conjugates, and multi-specific antibodies.  Incorporating SSP into early-phase clinical trials could advance the development of next-generation cancer therapeutics by uncovering mechanisms of response and resistance, guiding individualized dosing and identifying spatial biomarkers for participant stratification.

5/8 💡 These results suggest that improving antibody therapy may require not only better targets, but also strategies to overcome spatial barriers within the tumor microenvironment.

6/8 💡The SSP platform is broadly applicable to antibody-based therapeutics, including immune checkpoint inhibitors, antibody-drug conjugates, and multi-specific antibodies.  Incorporating SSP into early-phase clinical trials could advance the development of next-generation cancer therapeutics by uncovering mechanisms of response and resistance, guiding individualized dosing and identifying spatial biomarkers for participant stratification.

5/8 💡 These results suggest that improving antibody therapy may require not only better targets, but also strategies to overcome spatial barriers within the tumor microenvironment.

@StanfordUrology @StanfordCancer @StanfordMIPS @stanfordimmuno @stanfordcbio @bioe_stanford @StanfordBioX

Please RT: The Lu Lab at Stanford is hiring a postdoc in Spatial Biology & Therapeutics. Comp bio, cancer bio, and cancer therapeutics backgrounds welcome. Available immediately; start date flexible. Details in attached ad. Apply: guolanlu@stanford.edu. Lab website:med.stanford.edu/guolanlulab.ht…