HTLV Aware

Seroepidemiology of HTLV-I infection in northeast Thailand: a four year surveillance popline.org/node/1199?v=552

Our lab member Koki Niimura, a 2nd-year medical student at #Kumamoto Uni presented his research “Single-cell multiome analysis of ATL patients peripheral blood: HTLV-1 gene expression” in the Young Shibasaburo Research Presentation and won the Grand Prix Award. Congratulations!🎉

Confira no link: bahia.fiocruz.br/fiocruz-e-sesa…

#️⃣ T-CELL NEOPLASMS: From Skin to Systemic 1️⃣ Key Subtypes & Features 🦠 Adult T-cell Lymphoma (ATLL): •HTLV-1-associated (IV drug use, Japan/Caribbean endemic) •“Flower cells” on blood smear •Hypercalcemia (PTHrP-mediated) 🍂 Mycosis Fungoides (MF): •Eczema-like patches → plaques → tumors •“Cerebriform nuclei” on biopsy •Sézary syndrome (leukemic phase): •Circulating Sézary cells >1000/μL •Erythroderma + lymphadenopathy 2️⃣ Diagnostic Workup 🔬 Pathology Gold Standards: •MF: Epidermotropic CD4+ T-cells •ATLL: CD25+ (IL-2R) expression 🧪 Labs: •HTLV-1 serology (ATLL) •LDH (prognostic in MF) 3️⃣ Treatment (NCCN 2023) 💊 MF Early Stage: •Skin-directed: PUVA, topical nitrogen mustard •Biologics: Brentuximab vedotin (CD30+) 💉 Aggressive NHL (e.g., ATLL): •CHOEP + mogamulizumab (anti-CCR4) •Allo-HSCT for eligible patients ⚠️ Tumor Lysis Syndrome Prevention: •IV hydration + rasburicase (if LDH >2x ULN) 4️⃣ Lymph Node Red Flags 🔍 Malignant Features: •Virchow’s node (left supraclavicular) •Fixed/Rubbery texture •Growth >1cm over 4-6 weeks 📌 Mnemonics: 🔹 “T-CELL CLUES”: T - Tropical (HTLV-1) C - Cerebriform nuclei E - Erythroderma (Sézary) L - Lymphadenopathy L - LDH elevation U - Unrelenting pruritus E - Eczema-like rash S - Skin biopsy diagnostic 🔹 “RASH MF”: R - Retrovirus (HTLV) A - Atypical nuclei S - Sézary cells H - Hypercalcemia M - Mycosis fungoides F - Flower cells

Despite shared #retroviral features, HTLV-1 and HIV-1 employ distinct transcriptional strategies, a distinction examined in this comparative review with implications for divergent outcomes in #viral persistence and disease. 👉Read the full paper: tinyurl.com/2nah68rb

#HTLV-1 & #HIV-1: related origins, distinct regulation. Just out @VirusesMDPI : a comparative #review of #transcriptional regulatory mechanisms & outcomes. Honored to share this first review milestone with my mentor, Prof. @SatoYorifumi 🧬🧭 Grateful for his guidance and scientific discussions shaping my journey in Retrovirology! 📌📖Read the full review 📝mdpi.com/1999-4915/18/1…

A case of myelopathy due to HTLV-1 infection link.springer.com/article/10.100… #hvhebron #neuro #nimm

Investigation of anti-HTLV I/Ii seroprevalence in healthy blood donors in Izmir region, Turkey popline.org/node/13230?v=2…

New study from 'Genes to Cells' reveals how m6A RNA modification controls HTLV-1 Tax expression and reshapes host gene programs—highlighting viral latency mechanisms and potential therapeutic intervention and prophylaxis. #RNAmodification #epigenetics ➡️ow.ly/jscj50XTe0F

The 54th Annual Meeting of the Japanese Society for Immunology (10-12 Dec 2025, #Himeji) brought together 1,600+ participants. Our lab member, Dr. M. Ishrat Jahan, presented an HTLV-1 transgenic mouse model to study virus-driven immune dysregulation. #HTLV #Japan #Immunology

During #GVN’s 2025 Short Course in Translational Virology, participants toured the USF Virology Institute with Dr. Yutaka Tagaya (@USouthFlorida, @USFHealth), exploring HIV and HTLV-1 research labs and a newly renovated BSL-3 facility. #EducationandTraining #PandemicPreparedness

Human T-Lymphotropic Virus (HTLV): Epidemiology, Genetic, Pathogenesis, and Future Challenges ✍️by Branda et al. ➡️mdpi.com/1999-4915/17/5…

The presence of #HTLV can be detected by a blood test. HTLV infection does not show up in routine blood tests such as those requested by your family doctor or routine hospital tests. #HTLVaware

The treatment of HAM/TSP symptoms involves not only medication use but also multidisciplinary follow-up involving physiotherapy and psychotherapy and other specialties #HTLVaware

Investigation of anti-HTLV I/Ii seroprevalence in healthy blood donors in Izmir region, Turkey popline.org/node/13230?v=2…

Dr. Juan Carlos Ramos presented "A Phase 2 trial of AI-BEL (AZT/Interferon-α plus Belinostat) for HTLV-1 related adult T-cell leukemia-lymphoma: Final safety and efficacy Results" at #ASH25. Learn more: Sylvester.org/ASH25

潜伏50年で白血病や神経難病リスク「HTLV-1ウイルス」国内65万人が感染　うち半分は九州地方に集中　宮崎大・梅北医師は検査の重要性を訴える youtu.be/eIFEUSPbkxM?si… @YouTubeより

Prof. Yorifumi Satou and our lab members attended the 11th Annual Meeting of the Japanese Society for HTLV-1 Research, which took place at the Kagoshima Kenmin Koryu Center. This year, the meeting’s theme is “The Future of HTLV-1 Research Bridging Basic and Clinical Science”.

#HTLV #Epidemiology #HAM/TSP #HTLVaware

Osaka Castle was lit red tonight for HTLV awareness.