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High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes - @PKU1898 go.nature.com/47yENVJ

Researchers led by Kole Roybal, PhD, Director of the PICI Center at @UCSF, (@roybal_lab) have developed SNIPR (synthetic intramembrane proteolysis receptor), which enables T cells to detect soluble tumor signals & activate selectively within tumors: nature.com/articles/s4158… (1/3)

MIT University just released free online courses. No payment is required. Here are 7 courses you don't want to miss in 2024:

Beta-version of the new VISTA Enhancer Browser, 7 years in the making, with support for developmental stages, different species and variant comparison is finally online. Feedback is welcome! vista-enhancer.lbl.gov #enhancers #embryos #evodevo

Thank you @TheMarkFdn for this great opportunity to join the community with amazing scientists to conquer the challenges in science.

extremely excited to share our new story on the impact of JAK inhibition on responses to immune checkpoint blockade in lung cancer patients! 🧬🧑‍🔬 thread on our main findings 🧵 1/n science.org/doi/10.1126/sc…

Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method go.nature.com/4akbFkj

30-COLOR DNA-PAINT at 3D sub-15 nm RESOLUTION. We are overly excited to announce the publication of our latest work “Spatial proteomics in neurons at single-protein resolution” in @CellCellPress. Huge collaborative effort led by @EduardUnterauer. 1/9 cell.com/cell/fulltext/…

You can now read the March issue of Cancer Cell: cell.com/cancer-cell/is…

TIGER: Tumor Immunotherapy Gene Expression Resource buff.ly/4bjCy9M

Epigenetics Conference Spotlight #1 of 5: Engage with industry leaders at Keystone Symposia: "Epigenetic Mechanisms and Cancer Treatment." Abstract deadlines may have passed, but registration is still open! Check out more 2024 conferences: hubs.la/Q02gV-WY0

Today we report in @NatureBiotech an engineered virus-like particle system for in vivo delivery of prime editor protein-RNA complexes. This PE-eVLP platform can support therapeutic prime editing in animal models of genetic disease. /1 drive.google.com/file/d/1xd7Yzz…

Excited to share a milestone in our forward genetics developments! Today in @Nature we report massive mutagenesis screening in T cells with base editors, increasing resolution from genes to nucleotides nature.com/articles/s4158… A @MarsonLab story with my dear friend @carlcward 1/10

Today we report in @CellCellPress a suite of engineered and PACE-evolved prime editor variants PE6a-g. These new prime editors improve the activity, in vivo deliverability, and in vivo editing efficiency of prime editing. sciencedirect.com/science/articl… PDF:drive.google.com/file/d/11959ct… (1/15)

HHMI Investigator David Liu (@davidrliu) & his lab have developed new prime editors for gene editing. Their improved technology uses smaller editing molecules, which could make it easier to deliver cells to key parts of the body as new disease treatments. hhmi.news/3sBt7ka

The Tang group presents scNanoHi-C: a single cell Hi-C method based on nanopore long-read sequencing. scNanoHi-C allows researchers to capture high-order chromatin structures and detect genomic variations such as CNVs and SVs. nature.com/articles/s4159…

A high-throughput screen improves lipid nanoparticle delivery of gene editors in the lung go.nature.com/3KlMaFA

Online at @nature: “Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer” by @TheVinodLab nature.com/articles/s4158… #cancer #clinicaltrials

Enhanced axial resolution for 3D SIM is achieved with deep learning or four-beam interference go.nature.com/3kLNoQc