The Hartwig Group

The group goes to John’s house for good food and a great time! Tap to see a very proud John of his paella 🥘

Can whole-cell biosynthesis by artificial metalloenzymes escape from E. coli-land? We're Gram-positive! See how we leveraged a Streptomyces albus chassis for iridium-catalyzed cyclopropanation—now in JACS! In collaboration with the @Keasling_Lab. doi.org/10.1021/jacs.6…

Hot off the presses! C-H activation by uranium oxo photocatalysis--now made site-selective by ligand control. Longer lifetimes. Higher activity. All possible with blue light. In collaboration with the lab of @ProfArno. Now in JACS: doi.org/10.1021/jacs.6…

The newest update to @SynStrategy is live, bringing a top requested feature: a quiz function! Save reactions to custom datasets and test your knowledge across 3 quiz or flashcard formats. Check it out! iOS: apps.apple.com/de/app/synstra… Android: play.google.com/store/apps/det… #ChemTwitter

This is fantastic!

Our postdoc @Willi_Amberg built @SynStrategy a learning tool that categorizes 500+ reactions by functional group with 400+ total synthesis examples. If you’re into #OrgChem, check it out (it’s free)! iOS: apps.apple.com/de/app/synstra… Android: play.google.com/store/apps/det… #ChemTwitter

Mechanism-Inspired Ligand Design for Efficient Copper-Catalyzed C–N Coupling of Aryl and Heteroaryl Chlorides | Journal of the American Chemical Society @UCBerkeley @UCB_Chemistry @HartwigGroup pubs.acs.org/doi/10.1021/ja…

Observed versus Predicted Reactivity, Selectivity, and Mechanism of Iridium Catalysts with Pyridyl Carbene Ligands for the Borylation of C–H Bonds | Journal of the American Chemical Society @UCBerkeley @HartwigGroup pubs.acs.org/doi/10.1021/ja…

Observed versus Predicted Reactivity, Selectivity, and Mechanism of Iridium Catalysts with Pyridyl Carbene Ligands for the Borylation of C–H Bonds (@J_A_C_S): pubs.acs.org/doi/10.1021/ja… (@HartwigGroup).

Illuminating the Effects of Interchain Interactions on the Catalytic Amidation of C–H Bonds in Polyethylenes | Journal of the American Chemical Society @HartwigGroup @UCB_Chemistry @UCBerkeley pubs.acs.org/doi/10.1021/ja…

Mapping the Undirected Borylation of C(sp3)–H Bonds in Strained Rings (@J_A_C_S): pubs.acs.org/doi/10.1021/ja… (@HartwigGroup).

Mapping the Undirected Borylation of C(sp3)–H Bonds in Strained Rings | Journal of the American Chemical Society @HartwigGroup @UCBerkeley @UCB_Chemistry pubs.acs.org/doi/10.1021/ja…

#AmBeedNewsletter ✨ Recently, the Hartwig Group (@HartwigGroup) reported an inexpensive, mild, and soluble base suitable for small & large scales with excellent functional group tolerance. This work has been published in @J_A_C_S. 💡Key Highlights ✅ New L147/K‑2‑EH system enables mild and efficient C–N coupling of diverse amines with aryl halides/nonaflates. ✅ Excellent tolerance for base-sensitive functional groups. ✅ Over 6,000 substrates analyzed; 28 nucleophile and 16 electrophile clusters mapped. ✅ QSRR models identify key structural features for reactivity. The author mentioned in supporting information that some of the starting materials were purchased from AmBeed. We are honored to contribute to this groundbreaking research. 📚🔻 𝐑𝐞𝐚𝐝 𝐦𝐨𝐫𝐞 𝐰𝐢𝐭𝐡 𝐀𝐦𝐛𝐞𝐞𝐝 ambeed.com/newsdetail/Joh… #OrganicChemistry #PdCatalysis #MedicinalChemistry #DrugDiscovery #AmBeed #UTD #JACS

Check out this blog post by Derek Lowe in @ScienceMagazine where he uses our new C-N coupling method developed in collaboration with @abbvie! science.org/content/blog-p…

Excited to share our new method for Pd-catalyzed C–N cross-coupling, now published in @J_A_C_S ! This method utilizes an inexpensive, mild, and soluble base suitable for small & large scales with excellent functional group tolerance. doi.org/10.1021/jacs.5…

Catalytic organometallics ✔️ C-H functionalization ✔️ Olefin hydrofunctuonalization ✔️ Enantioselective allylic amination ✔️ Polymer upcycling ✔️ …and now artificial metalloenzymes💥 @HartwigGroup #JCO2025

Site- Stereo- & Chemoselective Enzymatic Terpeneoid Halogenation by Substrate Masquerade | Journal of the American Chemical Society @UMichResearch @UMich @Michiganchem @NarayanLab @AlisonNarayanUM @UCBerkeley @UCB_Chemistry @JohnFHartwig1 @HartwigGroup pubs.acs.org/doi/10.1021/ja…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”

Support UC Berkeley’s College of Chemistry! givingday.berkeley.edu/giving-day/106…

Catalytic Borylation of Poly(vinyl chloride) Produces Adhesive Materials (@HartwigGroup): pubs.acs.org/doi/10.1021/ja… (@J_A_C_S)

Enantioselective Syn. of Spirocyclic N-Containing Heterocycles Catalyzed by an Ir-Containing #Cytochrome by Jingtong Xu, Brandon Bloomer,John Brunn, Andrew Quest,Sukriyo Chakraborty, Joseph Schneider, Douglas Clark, @HartwigGroup @UCB_Chemistry in @J_A_C_S pubs.acs.org/doi/10.1021/ja…