MO

Acute SARS-CoV-2 viral load and systemic inflammation are associated with neuropsychiatric and musculoskeletal symptoms in long COVID 🚨Your “mild/asymptomatic” COVID wasn’t mild/asymptomatic. Study finds that a high viral load can silently seed you with long-term brain + body damage(LC)! ➡️A retrospective case-control study of 300 middle-aged Pakistani adults (30-60 years) with prior mild/asymptomatic COVID-19, assessed ~10 months post-infection at Dow University Hospital, Karachi, ➡️Long COVID (symptoms persisting >3 months) affected 59% (177 participants), ➡️Dominant Symptoms: Neuropsychiatric (e.g, headache, brain fog: 35%) and musculoskeletal (e.g, myalgia, fatigue: 32.2%) were most common, ➡️Biomarker Differences: Long COVID group showed lower haemoglobin, RBC, MCHC, higher WBC and lymphocytes, and elevated inflammatory markers (IL-6, ferritin) with deficiencies in vitamin D3 and B12 compared to controls (all p<0.05), ➡️Acute Viral Load Link: - Higher acute SARS-CoV-2 viral load (low Ct values ≤20) strongly associated with neuropsychiatric (75.8%, p<0.001) and musculoskeletal symptoms (57.9%, p=0.001), - Inverse correlations with IL-6 and ferritin, ➡️Adjusted Associations: Multivariable regression linked neuropsychiatric symptoms to higher lymphocytes, IL-6, ferritin, and vitamin D deficiency, musculoskeletal symptoms to vitamin D deficiency and ferritin levels, ➡️Implications & Limitations: - Persistent inflammation and micronutrient issues post-mild infection may drive specific Long COVID phenotypes, - Single-center design, self-reported symptoms, and lack of pre-infection baselines limit generalizability, - The study explicitly excluded anyone with more than one COVID-19 infection and vaccination status was not explored, By excluding reinfections and ignoring vaccination entirely, the study isolates the effect of a single mild infection yet still finds high rates of persistent symptoms and measurable biological changes, reinforcing that even one “mild/asymptomatic” encounter with the virus can leave a lasting mark. ‼️So, Important conclusions: 1. AGAIN, even mild/asymptomatic COVID-19 can leave a lasting biological footprint detectable in routine labs and tied to acute viral burden, underscoring that “mild” infection is no guarantee of full recovery, especially in populations with prevalent micronutrient gaps(Parkistan). 2. Erectile dysfunction briefly discussed but has been the focus of other studies. A reminder: Even “mild” COVID can silently damage the vascular and hormonal systems that power erections, leaving maybe up to 1 in 5 men with lasting ED years later, a stark reminder that Long COVID doesn’t spare intimate health but seems to carry, as usually, a taboo! 3. Higher acute viral burden and sustained inflammation during mild/asymptomatic COVID-19 can seed debilitating long-term neuropsychiatric and musculoskeletal symptoms in nearly 6 out of 10 survivors. #AvoidSars2 #AvoidReinfections #IntimateHealth journals.plos.org/plosone/articl…

Our Rapamycin & Exercise clinical trial has just been published! The topline result? Rapamycin didn't help. Instead, it may have made things worse. Here's what we found 🧵 onlinelibrary.wiley.com/doi/epdf/10.10…

@BradStanfieldMD Sounds like you needed a "count by 5 pill pusher" to help out with the pharmaco-kinetics-dynamics of rapamycin, hmm.. eekkk.. id look at protein intake proximal to exercise for "gains". peace!

Cowboy bronc riding on a California beach with Panama blasting in the background is an immaculate vibe.

Here is my talk on how studying viral infections can teach us a lot about the immune system, and how we can use those insights to develop vaccines against viruses. "Night science moments" make science so exciting 🌓 @NightScienceIns @ItaiYanai cassyni.com/events/HjViw2S…

@ChrisMasterjohn Sounds like a bad contract... Active ingredient costs? IMO, its a possibility. Where is a good tree when ya need one, ARB.. close. I am Forest Ranger, at least thats what my HS counselor said! I FU CM.. Peace!

If you believe in free markets, you should believe in Food First Pharma Last and Nature First Tech Last. Why? Because you should have the same respect for complexity. There are about 8 billion people in the world and there are about 30 trillion cells in your body. Free markets are the superior way to distribute resources and set prices because the billions of market participants supply little pieces of information involved in continuous feedback loops that no small committee of experts could ever effectively analyze. If you believe this, you believe that markets with billions of participants are too complex for experts to control with fiat decrees. But there are 30 trillion cells in your body, which is 3,750 more participants in your bodily economy than there are humans in the global economy. Complexity doesn't scale according to the number of participants. It scales according to the number of interactive pairings. There are 32 quintillion potential pairings in the global economy and 450 septillion potential pairings in the bodily economy, making your body 14 million times more complex than the global economy. Expert intervention into your bodily economy therefore carries the risk of being 14 million times more foolish than expert intervention into the economy. None of this means we should dismiss experts or interventions wholesale. Rather, we should have tremendous respect for the possibility that the collective wisdom of the 450 septillion potential cellular relationships spontaneously engaging in trade amongst each other within your body and setting the prices of everything with redox ratios, chemical gradients, transcription factors, and hormones is much greater than the wisdom of any expert. This means we have tremendous potential to be wrong when intentionally disturbing the system. Your body responds to exercise, altitude, meditation, and other practices with tremendous complexity we can only partially understand. If you try to make a drug to achieve the same thing, you intervene with a one-molecule-one-receptor pairing, which is 450,000,000,000,000,000,000,000,000 times less sophisticated than the number of cell-cell pairings in your body.

@S1_be_BioWeapon @JesslovesMJK @drterrysimpson @DrJ_surgeon Weird how the SEB always gets left out of the convo. You look at the math, you look at the Furin site, and then... boom, SEB superantigenic motif right next to it. The odds of those ‘coincidences’ stacking up in one jump are vanishingly small.

@JesslovesMJK @drterrysimpson @DrJ_surgeon Add the evidence of the 2017 moderna patent Trifecta 1) SEB signaling motif overlays it 2) Furin Cleavage site 3) IVM binding site (built on antidote)

You can either: take a controlled, studied dose that trains the immune system or take your chances with the actual virus during pregnancy One of these was designed in a lab. The other doesn’t care that you’re pregnant. The real trade-off Not vaccinating doesn’t mean “no risk.” It means choosing infection risk instead of vaccine risk. And infection: lasts longer inflames more carries real complications for both mother and baby

@JesslovesMJK @drterrysimpson @DrJ_surgeon 1 passage/jump in the tree 4 inserts? the other three? people need to know all... its..hmm. ( coincidental probabilities diminish nature). Peace!

The furin cleavage site specific to SARS-2 is absolutely unique. You've downgraded your own credibility by stating this falsity publicly. The PRRAR insertion is absent from all other known sarbecoviruses, including the closest relatives RaTG13, BANAL-20-52, and RmYN02, which retain only a monobasic arginine (...R↓S...) at the equivalent site and are not cleavable by furin there. While furin cleavage sites do occur naturally at the S1/S2 junction in more distant coronaviruses - such as MERS-CoV (different polybasic motif), some embecoviruses (OC43, HKU1), and certain alphacoronaviruses - their amino acid sequences and flanking contexts differ from SARS-CoV-2’s PRRAR. None match the specific PRRA insertion or exact motif found exclusively in SARS-CoV-2.

Pro-inflammatory cytokines, such as IL-1b, can drive the neurotoxic accumulation of quinolinic acid (QUIN). QUIN can cause cell death and neuroinflammation that triggers a never-ending loop of even more cell death and more neuroinflammation...🧵

@DrMichaelScoma "locus minoris resistentiae", memories... old injuries forgotten, they will find them and light them up once again..

There are some recurrent patterns in Long COVID and ME/CFS that I believe many are being left in the dark about. I’ll speak to this point later… 
What aspect(s) of your disease have proven most difficult for providers to explain in your particular case?

This is great news! Now we need to show that these accumulations are amyloid in nature.

Is COVID Causing Immune Collapse? The Science Behind the Claims x.com/i/broadcasts/1…

Absolutely. Fascinating. Friday Hope: Quercetin, Vitamin D and Curcumin All Modulate TGF-β and its Effects Further understanding of why the star supplements for COVID/Spike Protein Disease/Injury are the star supplements.

@Parsifaler dont forget the pepper on those curcumin eggs!! IYKYK!!

wmcresearch.substack.com/p/friday-hope-… One-Time Donation (Stripe’s “Buy Me A Coffee”) buy.stripe.com/6oUbJ0auFaWkcL…

@exosome Getting me all SASPy!!

#covid19 induces senescence of #lung cells through macrophage activation should all #covid19 patients take #senovax? pmc.ncbi.nlm.nih.gov/articles/PMC12…

@HouseLyndseyRN Best go find some garlic just in case someone is creeping around at night!! IYKYK! Sending positive vibes for a successful procedure!! Peace!

Saturday Morning waking up in Japan its a beautiful day :)

8/8) Ultimately, this work: • Advances understanding of thromboinflammatory disease • Supports development of new biomarker strategies Ultimately, this is part of a growing effort to better define and stratify post-viral and inflammatory conditions. Much more work is needed, including larger sample sizes; but this provides an important step forward.

1/7) We are excited to share our preprint, where we present a method to measure thrombo-inflammation that lead to systemic thrombotic endothelialitis in Long COVID, other post-viral and inflammatory diseases in general: biorxiv.org/content/10.648… with @dbkell and lead author Anél Thompson

AI help with a theory poster... (typos..i know..but informative)

The Rockies intentionally walked Jackson Merrill and Manny Machado to pitch to Xander Bogaerts ... BOGEY WENT BOOM 💥