Henver Brunetta

We present our MetaProViz #Rpackage for #metabolomics analysis & prior knowledge integration to generate mechanistic hypotheses on how metabolic changes affect metabolite classes, pathways & environment interaction 🔗biorxiv.org/content/10.110… 📦 saezlab.github.io/MetaProViz/ 🧵 Thread

check out our latest "ACLY inhibition promotes tumour immunity and suppresses liver cancer" nature.com/articles/s4158… @NaturePortfolio @Nature

Oxidative Phosphorylation in Uncoupled Mitochondria onlinelibrary.wiley.com/doi/10.1002/bi…

@Pluchinolab Thank you for sharing our work 😊

@HenverBrunetta summarized the content in this video: m.youtube.com/watch?v=t1c4kl…

A small piece about IF1 in brown adipocytes 🤌🏼❤️

RESEARCH | @LoganTownsend86, @DrGregSteinberg et. al. (@MacMODR) #Anxiety -like behaviour in mice, as a result of psychological #stress, is shown to be mediated by #GDF15 release in response to adipose tissue #lipolysis 🐭 nature.com/articles/s4225…

@Chrest_brett @KFW_Lab Congrats Brett, very interesting. Can’t wait to read carefully

📢New @KFW_Lab paper out! AML mitochondria remain unperturbed & phenotypically stable under diverse nutrient conditions. And rather than specific nutrients or physiological relevance, AML cell proliferation is influenced by the complete nutrient profile 👉 cancerandmetabolism.biomedcentral.com/articles/10.11…

@AnaVujic5 @thomaskrieglab Very important study Ana. Congratulations to the whole team!!!

🚨 New paper out from us, reveals a novel role for mitochondrial RET-ROS in #HFpEF. 🧬 ND6 mutation ➡️ 🫀 Hypertrophy 💔 Diastolic dysfunction 🏃‍♂️ ↓ Exercise capacity 💪 ↑ Lean mass 🍩 HFD worsened metabolism ✅ Exercise reversed many effects! doi.org/10.1152/ajphea…

GDF15 links adipose tissue lipolysis with anxiety go.nature.com/42McVw6

@SableSys @DrGregSteinberg @MacMODR @LoganTownsend86

More fascinating Promethion-powered science from @DrGregSteinberg & colleagues @MacMODR - providing molecular insights into the mechanisms linking metabolism & behavior, & suggesting that inhibition of GDF15–GFRAL signalling might reduce acute anxiety. nature.com/articles/s4225…

Signalling from adipose tissue to the brain is not just about leptin nature.com/articles/s4225… @NatMetabolism

A word I don’t use often to describe a paper, but what an elegant work here. Bravo ⁦@LoganTownsend86⁩ nature.com/articles/s4225…

@KFW_Lab @ScienceAdvances Beautiful work

📢 New KFW Lab paper out now in @ScienceAdvances! 📢 We show that AML cells resist chemotherapy by reversing the ATP synthase reaction—supporting oxidative metabolism and maintaining mitochondrial membrane potential. 🔬🧬 👉 science.org/doi/10.1126/sc…

Reunited with #mitolab322 @HollowayMitoLab @UofG_HHNS to celebrate Heather Petrick’s PhD defence in Maastricht 🇳🇱

Your reading list is here. Beautiful #mitochondria and #metabolism studies. Thanks ⁦@Bims_BiomedNews⁩ for pre-sorting biomed.news/bims-mimcad/20…

@Chrest_brett Great stuff @Chrest_brett thanks for sharing

If you study cancer metabolism, you need to read this. Then read it again. pmc.ncbi.nlm.nih.gov/articles/PMC11…

Amazing papers this week on #mitochondria and #metabolism. Check them out now!!! Thanks ⁦@Bims_BiomedNews⁩ for pre-sorting biomed.news/bims-mimcad/20…

Happy New Year everyone! Starting 2025 with a curated list of papers on #mitochondria and #metabolic diseases. Thanks ⁦@Bims_BiomedNews⁩ for pre-sorting #p3" target="_blank" rel="nofollow noopener">biomed.news/bims-mimcad/20…

Ever heard of the Athlete’s Paradox? Despite high intramyocellular lipids, endurance athletes have superior insulin sensitivity. A deep dive into the metabolic environment of athletes' myocytes! #Metabolism #AthletesParadox #InsulinSensitivity #abstract" target="_blank" rel="nofollow noopener">science.org/doi/10.1126/sc…