Herzon Lab

Check out our latest work on colibactin in ACS Chemical Biology. Congratulations to the whole team on their work! pubs.acs.org/doi/full/10.10…

Nice story about our GBM research by Yale Student Isabella Backman. There are few treatment options for these patients, and none are curative. We are rooting for Merck and Company and hope they'll be able to get these drugs into the clinic soon! medicine.yale.edu/news-article/f…

Researchers at @Yale, including Camille Dreyfus Teacher-Scholars Seth Herzon (@HerzonLab) and Jason Crawford, "have synthesized a complex, potentially cancer-fighting molecule found in sea sponges discovered off the coast of South Korea." news.yale.edu/2025/11/13/soa…

Congratulations to our very own Dr. Zechun Wang for his successful PhD defense! In his time with us, he has worked on a multitude of projects, including our recent synthesis and biological evaluation of (–)-gukulenin A! Read about it here: science.org/doi/10.1126/sc…

Three-component assembly and structure–function relationships of (–)-gukulenin A by Vaani Gupta, Zechun Wang, Joshua B. Combs, Timothy Wright, Lei Chen, Boxu Lin, Ryan Holmes, Bo Qin, Joonseok Oh, Jason M. Crawford, and Seth B. Herzon @HerzonLab at @YaleChem in @ScienceMagazine science.org/doi/10.1126/sc…

Members of Yale's @HerzonLab have led the synthesization of a complex, potentially #cancer-fighting molecule found in #seasponges discovered off the coast of South Korea. #gukuleninA news.yale.edu/2025/11/13/soa… @SmilowCancer @YaleChem @ScienceMagazine

For a commentary on this work, check out this @cenmag piece written by @beth_halford: (4/4) cen.acs.org/synthesis/medi…

We had many failed strategies and could have walked away from the project a half dozen times. We could not be more proud of the team on this. (3/4)

Out now in Science: Three-component assembly and structure–function relationships of (–)-gukulenin A, as a first release research article. Congrats to the team! (1/4) science.org/doi/10.1126/sc…

Out today in @J_A_C_S is the first synthesis from our group!! We report a convergent and stereoselective total synthesis of the nominal structure of Talaromyolide D. Huge congrats to Bo and Alex! @nyuchemistry @TotalSynthesis pubs.acs.org/doi/10.1021/ja…

Absolutely beautiful !@MartinTomanik your team beats everyone in using these two bifunctional pyridone ligands for CH hydroxylation. The sp2 CH sp3 coupling with epoxide by MPAA ligand will also inspire more use of such sp2 Sp3 coupling. congrats ! @HerzonLab you trained him well

#TotalSynthesis of Chartelline C by Noah M. Bartfield (@NaOHBartfield), Brandon W. Alexander, and Seth B. Herzon @HerzonLab at @YaleChem in @J_A_C_S pubs.acs.org/doi/10.1021/ja…

Total Synthesis of Chartelline C | Journal of the American Chemical Society @Yale @YaleChem pubs.acs.org/doi/10.1021/ja…

The total synthesis of chartelline C! Accomplished in a small number of transformations from material intercepted en route to the securamines. Each step was informed by the unique topology and unconventional reactivity of these isolates 🥳🙌 pubs.acs.org/doi/10.1021/ja…

Congratulations to our undergraduate trainee, Sam Charney, for receiving a 2025 Summer Undergraduate Research Fellowship from the ACS DOC!

Prof. Seth Herzon accepting the @AmerChemSociety Award for Creative Work in Synthetic Organic Chemistry at the 2025 American Chemical Society meeting in San Diego. The group is proud to accept this honor! Photo credits: EPNAC.com

Some of these natural products were made by @BaranLabReads @HoveydaLab @Shenvi_Lab @KrischeLab @GargLab @HerzonLab @JohnsonGroup @brianstoltz70 @Brimble_Lab @TheFerreiraLab and more!

Congratulations to the 7 members of @YaleCancer receiving Blavatnik Awards: Dr. Demetrios Braddock @yalepathology; @CraigMCrews; Dr. Seth Herzon @HerzonLab; Dr. Richard Kibbey; Dr. Carrie Lucas @lucasite_lab; Dr. Markus Müschen @MuschenLab; Dr. Martin Schwartz @YaleCardiology @YaleBme. @SmilowCancer @YaleMed @YNHH

Congratulations to Mikaela, Zikki, and Alex! (2/2)

A Stereoselective Oxidative Dimerization En Route to (−)-Lomaiviticin A. This strategy enables access to the natural stereoisomer of the lomaiviticin skeleton, featuring a highly diastereoselective late-stage dimerization. Out now in @JOC_OL! (1/2) pubs.acs.org/doi/10.1021/ac…