HullemanLab

152 posts

HullemanLab

@HullemanLab

A vision research lab leveraging chemical biology, biochemistry, drug discovery, and gene therapy to develop unique approaches for retinal diseases.

Minneapolis, MN Katılım Nisan 2021

256 Takip Edilen264 Takipçiler

HullemanLab@HullemanLab·31 Ara

After a year-long hiatus from X, it is nice to see a shout-out from @NEIDirector Michael Chiang on our #Nlrp3 paper just before ringing in the New Year! #NIHfunded #UMNproud Cell Death and Disease article link: go.nature.com/4pKjd8s

Michael F. Chiang, MD@NEIDirector

#NIHfunded work shows targeting the inflammatory sensor Nlrp3 reduced early #AMD-like pathology in preclinical models, underscoring inflammation as a therapeutic target. @Umnmedschool @HullemanLab @UTSWMedCenter #VisionResearch @cddpress paper: go.nature.com/4pKjd8s

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HullemanLab@HullemanLab·23 Ara

#HappyHolidays from the Hulleman Lab! Our Texas-born #Christmas cactus has been working overtime this year!

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HullemanLab@HullemanLab·17 Ara

Cool to see our work highlighted in the @promega Connections blog. Thanks to Jordan Villanueva for the write up! Check it out below. promegaconnections.com/academic-acces…

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HullemanLab@HullemanLab·11 Ara

Congrats to Nathan Johnson, Ph.D. for securing a VitreoRetinal Surgery Foundation (VRSF) Fellowship to extend his time in the lab!

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HullemanLab@HullemanLab·4 Ara

Looking forward to presenting @UciCtvr this Friday! Hope you can attend, see announcement below.

Brunson Center for Translational Vision Research@UciCtvr

Small molecule remodeling of the ECM prevents AMD-like pathology More details and link to join here: ctvr.uci.edu/distinguished-…

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HullemanLab@HullemanLab·20 Kas

Welcome to @MPaT_PHCL_UMN rotation students Jillian VanTreeck and Julian Yang. Two full weeks in and already some successful HiBiT edits. It’s great to have their enthusiasm in the lab! #visionscience #ophthalmology

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HullemanLab@HullemanLab·15 Kas

Proud of our first yellow flame plasmid in @Addgene! Request yours while supplies last… addgene.org/192815/

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HullemanLab@HullemanLab·24 Eki

Don’t hit snooze after your parrilla-induced siesta today! Be sure to stop by our #ISER2024 session on small molecule therapies for retinal diseases - Quebracho B 5th Floor starting at 3:30PM. @iserworld

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HullemanLab@HullemanLab·21 Eki

What a difference a day makes - clearly fall in MN, lovely spring (almost summer) weather in Buenos Aires. #ISER2024 has started off with a strong program today. @iserworld

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HullemanLab@HullemanLab·5 Eyl

Great to see that our #AMD-related work was recognized by @NEIDirector! Beautiful photo credit: @StefPhDaniel and @pravz2505

Michael F. Chiang, MD@NEIDirector

From @UMNews: researchers led by John Hulleman discovered a new pathway to prevent #AMD (mouse model) by reducing the production of glycoprotein fibulin-3. #NEIfunded @umnmedschool @HullemanLab @JCI_insight paper: bit.ly/3MrBMfJ

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HullemanLab retweetledi

UMN Medical School@umnmedschool·21 Ağu

Exciting news: U of M researchers have discovered a potential new pathway to prevent age-related macular degeneration. Read more from John Hulleman, PhD ➡️: bit.ly/4dLYlrL. #MacularDegeneration | #AMD

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HullemanLab@HullemanLab·21 Ağu

#ISER2024 is 2 mo away! Mark your calendars - Yuanyuan Chen @UPMC and I are hosting a session on small molecule therapies for retinal degeneration. Talks by @StefPhDaniel, Liyun Zhang @HopkinsMedicine, Tim Corson @UofTPharmacy, Marco Bassetto @UciCtvr, and yours truly. @iserworld

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HullemanLab@HullemanLab·13 Ağu

Very excited to share our recent work just published in @JCI_Insight. Low level #GSK3 inhibition via CHIR99021 remodels the #ECM and prevents BLamDs in an early-onset #AMD mouse model. Congrats to Sophie DiCesare on a great paper! @UMNews insight.jci.org/articles/view/…

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HullemanLab@HullemanLab·5 Ağu

After dedicating 2+ yrs to the Lab, quantifying ~35,000 microns of Bruch’s memb./basal laminar deposits in TEM images, Antonio Ortega is now a Vivien Thomas PhD Scholar @HopkinsMedicine. Thankful for the opportunity to teach and learn from Ant and excited for his next chapter!

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HullemanLab@HullemanLab·24 Tem

In our latest work, we show that fibulin-3 cysteine mutations present in the human population can severely compromise secretion, affect #MMP2 activity, and trigger #ERstress with implications for human #ECM diseases. @biorxivpreprint @ClinGenResource biorxiv.org/cgi/content/sh…

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HullemanLab@HullemanLab·16 Tem

Happy to announce that we have received a two-year Regenerative Medicine Minnesota grant to develop next-gen tools to better study proteins implicated in age-related macular degeneration (#AMD). @UMNews @UMNmedschool #RegenMedMN

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HullemanLab@HullemanLab·11 Tem

Congrats to @StefPhDaniel for receiving a travel grant to attend the #ISER2024 meeting in Argentina. Also, welcome to medical student Nathan Johnson, who secured a summer research fellowship from the University of Minnesota-Duluth. #visionresearch #ophthalmology @iserworld

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HullemanLab@HullemanLab·5 Tem

It's hard to get 7 people in a photobooth. n = 4 for a partially successful whole lab picture. Happy Birthday Antonio!

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HullemanLab@HullemanLab·1 Tem

Over the past month the Hulleman Lab has grown substantially. It's great to welcome Emily Baker, Anna Roovers, Pravallika Kambhampati, and Harkamal Kaur to the team! #visionscience #ophthalmology

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HullemanLab@HullemanLab·27 Haz

An amazing resource @UMNresearch is the access to human donor eyes. Since ~2500 eyes are processed annually by @LionsGiftSight, we took a cool Lab Field Trip to learn about the process and watch a human globe dissection by the talented Sung Lee. #AMD #RPE

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Keşfet

@NEIDirector @promega @UciCtvr @MPaT_PHCL_UMN @Addgene @iserworld @StefPhDaniel @pravz2505