Huveneers Lab

A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and… disq.us/t/3wt3h0a

With Tong Xu, Vera Janssen and Nathalie Reinhard as shared first authors, we would like to thank everyone who contributed! #Angiogenesis #VascularBiology #Endothelial #PortWineStains #SturgeWeberSyndrome #AmsterdamUMC

The article also includes a full phosphoproteomic dataset mapping downstream signaling of the GNAQ p.R183Q mutation in endothelial cells. 🔗 Proteomic data available at: ebi.ac.uk/pride/archive/…

News from the lab! We identify the Calcineurin-NFAT-DSCR1.4 signaling pathway as a druggable driver of capillary malformations caused by the GNAQ p.R183Q mutation, which is associated with port-wine stains and Sturge-Weber syndrome. 🔗 Publication: rdcu.be/e2gRC

🔬 Join us in Barcelona to meet researchers working at the intersection of engineering and vascular biology and discover cutting-edge techniques in spatial omics, advanced imaging, and AI. #EMBOBuildNetworks @events.embl.org 13 – 15 May 2026 Register: s.embl.org/evb26-01-bl

Goodmorning all! The EVBO board is back online! Please see our amazing speaker list and reserve the following dates for the upcoming EVBO autumn seminars. You can registration for the Zoom through the link in the email from our EVBO secretary.

Interested in research on cell-cell junctions and vascular biology? We are recruiting a PhD student! werkenbij.amsterdamumc.org/en/vacatures/r…

The exciting, complete VAC 2025 program is now online! vacure-conference.net/index.php/prog… Don't wait to register! vacure-conference.net @vascern @hevas_nl @VASCAPA @CMTCOVM @ISSVA_org @PTENFoundation @LGDA_EU @LGDAlliance @AtavistikBio @PalvellaTX

VE-cadherin RGD motifs are dispensable for cell-cell junctions, endothelial barrier function and leukocyte extravasation biorxiv.org/cgi/content/sh… #biorxiv_cellbio

#EVBOSeminarSeries Moderated by Sine Karaman. Speakers: Rene Hägerling, Jurjan Aman and @chiara_testini. ⏰When: Tuesday, 10th December 2024, EU time (2PM UK). Place: online. See you there! For registration evbo.org

De Nederlandse universiteiten hebben een gezamenlijk manifest gepubliceerd waarin ze het kabinet oproepen de bezuiniginen op universiteiten en wetenschap te stoppen.

Interested in sonoporation as drug delivery approach in blood vessels? Mind the underlying endothelial cytoskeleton! Its organisation influences the endothelial response to ultrasound-activated microbubbles. New collaborative publication out led by Kooiman's lab from Erasmus MC

In their #OpenAccess Review, @vera_janssen1 and @Huveneers_lab @amsterdamumc explore how recent advances in fluorescence & electron microscopy along with biosensors & optogenetic tools have updated long-standing models of cell–cell adhesion. journals.biologists.com/jcs/article/13…

And it’s out - our special issue on ‘Imaging Cell Architecture and Dynamics’! Huge thanks to everyone - authors, reviewers and editors (@EM_STP and @guijacquemet) - who contributed! 🙌 #imaging #cellbiology #microscopy

@guijacquemet @vera_janssen1 and now we also know we need more funding for more microscopes....thanks to your special issue ;)

Cell–cell junctions in focus – imaging junctional architectures and dynamics at high resolution journals.biologists.com/jcs/article/13… What did advanced microscopists do to our point of view? #superresolution #volumeEM #optogenetics #biosensors with @vera_janssen1

in JCS Special Issue Imaging Cell Architecture and Dynamics!

@HaoYin20 Thanks Hao, we had to keep it short but tried to include (some of) your favourite topics!

#EndothelialCell Mechanics & Dynamics in #Angiogenesis An excellent up-to-date synthesis & insight!😆 👉Water influx of Tip cells to regulate cytoplasmic viscosity & actin dynamics 👉Mechanical plasticity & deformability of #ExtraCellularMatrix 👉#YAP/TAZ in mechanochemical feedback & #CollectiveCellMigration 👉Luminal pressure stretches EC to regulate membrane curvature-sensing protein 👉Junction-LINC proteins relay mechanical signals to coordinate actin & microtubules for vessel elongation & anastomosis 👉And my favorite topic: EC #Lumenogenesis @Huveneers_Lab @LabPhng Curr Opin Cell Biol 2024 sciencedirect.com/science/articl…

Drs. Stephan Huveneers (@Huveneers_Lab) and Li-Kun Phng (@LabPhng) discuss new conceptual advances gained from in vitro and in vivo models of #angiogenesis on the control of #endothelial cell dynamics. 📰 bit.ly/4eHTpE6