ICMUB

How to recapitulate in vitro what happens in cells? Not easy! We investigated how guanine (G)-rich sequences interact with one another to decipher G4-associated gene expression regulation Now in Nucleic Acids Res.: doi.org/10.1093/nar/gk… With @NJU1902 & @Polytechnique @CNRS

An ICMUB team has simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s The TASQs story @ACSPublications: doi.org/10.1021/acs.ac… This new article @ChemEurJ: doi.org/10.1002/chem.2…

A novel biotechnological application for DNA G-quadruplex #G4, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner Now in Anal. Chem.: pubs.acs.org/doi/10.1021/ac…

The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down) Now in ACS Bio & Med Chem Au: pubs.acs.org/doi/10.1021/ac…

A novel collaboration between @icmub (FR) and @NJU1902 (CN) which keeps on expanding the repertoire of biotechnological applications of G-quadruplex #G4, here to track undesired antibiotics in food. Now published in @an_chem 👉 doi.org/10.1021/acs.an…

An interview of D. Monchaud, @CNRS researcher @icmub now published @PourlaScience to discuss about the results of Simon Elsässer and @PKnipscheer recently published in Science 👉science.org/doi/10.1126/sc… 👉pourlascience.fr/sd/genetique/l… (sorry, in French only)

A fruitful collaboration between @icmub (FR) and @iitgn (IN) supported by @EMBOFellows led to a novel strategy to fight against colorectal cancer, which relies on the pharmacomodulation of G-quadruplex #G4 found in miRNA. Now published in @BMCBiology doi.org/10.1186/s12915…

A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) made in @ICMUB In collaboration with @UBI_pt and @WesternU 👉doi.org/10.1016/j.ijbi…

ICMUB is proud to have been associated with the very 1st meeting on DNA/RNA junctions IMAJ#1 organized by @dmonchaud.bsky.social and funded by @CNRSchimie (IRN). The meeting took place in Paris from 12 to 14 May, 2025 and was a real success! Great talks and enriching discussions!

@icmub was associated to a consortium steered by @crctoncopole to decipher how G-quadruplex #G4 RNA can be leveraged for mitochondrial translation-targeted therapy to fight against cancers Now in @NatureComms👍 @CNRSchimie @CNRS_Centre_Est @univbourgogne doi.org/10.1038/s41467…

In this new @J_A_C_S article, a collaboration between @ICMUB, @NanjingUnivers1, @Polytechnique and @univ_spn report on CoRP-seq, a technique that allows for mapping RNA G-quadruplex #G4 transcriptome-wide in a faster, cheaper and simpler manner! 👉 doi.org/10.1021/jacs.5…

In this @STARProtocols article, J. Mitteaux & D. Monchaud from @icmub describe in a step-by-step manner how to fish RNA G-quadruplex #G4 out from human cells using commercially available TASQs, either BioCyTASQ (sigmaaldrich.com/FR/en/product/…) or MultiTASQ (sigmaaldrich.com/FR/en/product/…)

Another beautiful collaboration between @ICMUB and @UTHealthHouston @McGovernMed which aims at deciphering the roles that G-quadruplex #G4 DNA and RNA play in human cells using chemical biology means. @CNRS @CNRSchimie @univbourgogne

A free-flowing and spirited discussion on @icmub research related to DNA structure oddities (G-quadruplex, #G4) that may have a profound impact on our daily lives (aging and age-related diseases). Thanks to the CNRS (@CNRS @CNRSchimie @CNRS_Centre_Est) for this opportunity

#chimie ⚗️ #ResultatScientifique 📕 🔎 l Une nouvelle cible #thérapeutique prometteuse sur l’ADN de cellules #cancéreuses et des molécules capables de s'y attaquer de manière sélective. 🤝 @univbourgogne @CNRS_Centre_Est @dmonchaud ➡️inc.cnrs.fr/fr/cnrsinfo/ci…

‼️highlight alert‼️ Thanks @CNRSchimie for highlighting this @icmub work done in collaboration with @agranzhan @institut_curie @SebBritton1 @IpbsToulouse Nicolas Chéron @Chimie__ENS and Lukas Trantirek @CEITEC_Brno

An @icmub contribution aiming at deciphering the roles that a peculiar DNA structure known as G-quadruplex #G4 plays in a neurodegenerative disease (XDP) published in @NAR_Open 👍👍👍 @CNRS @CNRSchimie @CNRS_Centre_Est @univbourgogne

Structural Optimization of Azacryptands for Targeting Three-Way DNA Junctions (David Monchaud and co-workers) @agranzhan @institut_curie @dmonchaud @icmub @CNRSchimie #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

An historical perspective on DNA interacting compounds used as anticancer agents, written by an @icmub @univbourgogne @CNRSchimie member in honour of Prof. Stephen Neidle @ucl @School_Pharmacy @ucllifesciences

Targeting DNA junctions for fighting against cancers! An @icmub work in collaboration with Paris, Toulouse and Brno (CZ). Congrats to all authors! @univbourgogne @CNRSchimie