Ines Hellmann

@dagarfield @EnardHellmannWG @zkliesmete @gokcen Thanx! Where are you now? We wanted to suggest you as a reviewer, but only found the old Berlin address.

@EnardHellmannWG @zkliesmete @IHellmann Oh I am so happy to see this out. @gokcen this looks like a fun one.

We are excited to share our latest manuscript on cis-regulatory evolution in primates: biorxiv.org/content/10.110… Congrats to @zkliesmete, @IHellmann and all co-authors! Short summary in a thread below ⬇️

Compensatory evolution has been suggested before as a common mode of evolution for CREs, it is only that for less pleiotropic elements this usually happens not within the same element, but between different CREs, i.e. the entire CRE jumps around.

It is just how this functional conservation these large pleiotropic CREs is achieved by redundancy, thus TFBS are moving around and different locations got fixed in different species: i.e. compensatory evolution within the same CRE.

Finally, we completed the story and are proud to share it with the world. Evidence for compensatory evolution within pleiotropic regulatory elements biorxiv.org/content/10.110…

$WLD Airdrop is LIVE!!! @pierresacoman @miyachi_satoshi @Casa_NUA @erudraeth @farrahappleman

Have you ever wondered whether your single cell transcriptome represents really only one tiny cell? Here, we get genotype based estimates of background RNA allowing us to estimate its effect on analysis and to benchmark background removal methods. biorxiv.org/content/10.110… #SCOG

@paperpile How can I integrate a Shared Folder into @overleaf , so that all authors can update the bib file?

Nothing makes sense in medicine except in the light of evolution. So well deserved as a scientist and person! Congratulations from us all 👏

After 2 years of zoom conferences, it was great to chat about science in person again at #SCGmeetsML. Thanks for all the feedback and a fantastic event overall!

@EnardHellmannWG @zkliesmete @ph_janssen Thank you all for your support and your wishes! Finally, there are no more administrative obstacles for me to supervise my fantastic PhD and Masters students.

Congratulations to @IHellmann on her habilitation! 🎓 Ines gave a great talk about "Evolution of Gene Regulation", summarizing a lot of the Enard/Hellmann group's work. Thank you for the inspiration and motivation for our upcoming projects!

Prime-seq – the most efficient method for RNA-seq currently available rna-seqblog.com/prime-seq-the-… via @@RNASeqBlog

The second study, led by @mad_kook and Piyush Joshi, leverages our human cerebellar single-cell atlas, 2,923 bulk transcriptomes from pediatric solid tumors, and 100 published single-cell transcriptome datasets from medulloblastoma, ependymoma, and pilocytic astrocytoma.

Based on these data, we established detailed cellular atlases across the development of the three species. The data can be interactively explored in a dedicated online resource: apps.kaessmannlab.org/sc-cerebellum-…

Our co-authors asked us to help to advertise for this article. I was considering to give the #RNASeqBlog a try. However, it seems to be down? The last message I got was from friday 2/12. Anybody knows what's going on?

Mouse lineage tracing and Single cell analysis show that Sox2+ myeloid-like cells promote blood vessel growth in glioblastomas authors.elsevier.com/sd/article/S24…

check out how the protein TRNP1 and its regulation co-evolve with brain folding in mammals bioRxiv viewer disq.us/t/3upqada

@ee_reh_neh Happy Birthday 🎂