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Latest from Ivaska Lab▶️ @johannalilja_, Kaivola et al. report an unanticipated way to kill KRAS mutant cancer cells by disrupting SHANK3-KRAS interaction 👌😎
Congratulations to all the authors and check the paper out here 👉rdcu.be/dTQDP
Johanna Ivaska@johannaivaska
What happens when unexpected happens!? 1) @johannalilja_ @IvaskaLab #JasminKaivola identified SHANK3 as a KRAS inhibitor 2) predicted SHANK3 depletion boosts KRASmut tumors 3) observed SHANK3 depletion kills KRAS-cells by ERK hyperactivation, apoptosis rdcu.be/dTQDP
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