Rahul Samant

We're #hiring a #postdoc--get in touch! Someone with expertise in 3D models (organoids/ALIs) and advanced imaging, and a passion to drive a project on how cellular #senescence and #proteostasis dysregulation contribute to tissue #ageing. Apply by 25th Feb babrahaminstitute.livevacancies.co.uk/#/job/details/…

Communication breakdown: senescent cells in interorgan communication of aging cell.com/trends/endocri…

Alveolar-Basal Intermediates Drive Pulmonary Fibrosis via Coordination of a Pro-Fibrotic Signaling Niche in Silicosis biorxiv.org/content/10.648… #biorxiv_sysbio

Scientists say they have made some of the first direct measurements of how long it takes a protein to fold – and the results were surprising go.nature.com/4rqMIw7

Aging may feel gradual… but what if it’s not? In our paper out today, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵

MitoTracker transfers from astrocytes to neurons independently of mitochondria dlvr.it/TRV0Fg

Lifelong behavioral screen reveals an architecture of vertebrate aging science.org/doi/10.1126/sc…

Some molecular machines, like ribosomes, persist for long periods in cells Could molecular aging of ribosomes shape how proteins are made? In our preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) biorxiv.org/content/10.648…

Stress-induced nucleolar rejuvenation via chaperone-mediated segregation in a filamentous fungus: rupress.org/jcb/article/22…

c-MYC is an aggregation-prone, amyloidogenic protein biorxiv.org/content/10.648… #biorxiv_cellbio

TDP-43 pathology triggers neuroinflammation and cognitive impairment by inducing microglial necroptosis: link.springer.com/article/10.103…

Nature research paper: Ageing promotes metastasis via activation of the integrated stress response go.nature.com/4b4nGxZ

Targeting the senescence–autophagy axis for idiopathic pulmonary fibrosis therapy dlvr.it/TRSGW9

Live-clearing 2.0 is there! Work from @TakeshiImaiLab in @naturemethods. 2nd major live clearing work after (Qu et al. Science, 2024), with a stronger emphasis on isotonic, minimally invasive conditions & preservation of neuronal physiology. #Sec51" target="_blank" rel="nofollow noopener">nature.com/articles/s4159…. Congrats!

Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer | Science science.org/doi/10.1126/sc…

New Review in Trends in Cell Biology with @n_szulc First integrative catalogue of 267 cullin-RING substrate receptors (93 linked to germline disorders) + programmatic-friendly Excel resource for the community. cell.com/trends/cell-bi…

New name. New place. Same great training opportunities from Babraham Bioinformatics at The Babraham Institute @BabrahamUK - virtually around the UK and rest of the world. Come and find us! biotrain.tv and on Blue Sky, Facebook and LinkedIn!

Final Chance!🚨 The abstract submission deadline for our #UbiquitinFunction meeting has been extended until Monday 16th March. Submit your abstract today to share your latest discoveries with the Ubiquitin research community. Don’t miss the chance to present and connect with colleagues in the field ➡️bit.ly/4bnlaSC

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish: nature.com/articles/s4358…

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress | Science Advances science.org/doi/10.1126/sc…

Excited to share our work at @MitOtalks this Thursday, March 5th! Hope to see you there!!