Jonathan Nelson (He/Him)

Thank you @ScienceMagazine for highlighting our research progress in this news article. Scientists make most authentic kidney replicas so far | Science | AAAS science.org/content/articl…

@CterminiPhD @organizolife I was wondering if you’ve created a spreadsheet (or other system) to keep track of progress of your mentees? Something to help guide and focus 1:1 meetings and make sure tasks don’t fall through the cracks (for both mentee and mentor).

It brings me so much joy to unveil organizō: an online forum for sharing organizational tools & resources to support scientific operations and mentoring. Seeing @organizolife come to life is beyond anything I could have dreamed. I guess I’m a founder now! organizolife.com

New Article! Expansion of human pluripotent stem cell–induced nephron progenitor cells (iNPCs) and the generation of nephron organoids from iNPCs bit.ly/4oWY76U

Excited to share that our latest study on Methylthioadenosine Phosphorylase (MTAP) inhibition in acute kidney injury has just been published at @AJPRenal ! During my PhD and postdoc in Dr. Kumar Sharma’s lab, we discovered that inhibiting MTAP offers significant protection against experimental AKI. Our findings show reduced renal injury, decreased inflammation, and preserved pathways related to proximal tubule adaptive repair post-injury. In addition, we analyzed human single cell RNA sequencing data available from the @KPMProject, revealing that MTAP is highly expressed in kidney injury marker-positive adaptive proximal tubule cells, showing its association to key players in AKI and potential to serve as a therapeutic target for promoting kidney repair. A huge thank you to my amazing collaborators and advisors Dr. Yidong Chen, Dr. @JWNdothelium, Abhinav Vetcha (my mentee), Wei Wei Wang, Dr. Li Kang, Dr. NAGARJUNACHARY RAGI, Dr. Soumya Maity, Dr. Hamid Rabb, Dr. Brian Reeves, and Dr. Kumar Sharma (my mentor) and the entire Center for Precision Medicine for their support @UTHealthSA @UTHSAResearch! And stay tuned for Part 2 of this project, super exciting new discoveries are on the way! journals.physiology.org/doi/full/10.11…

Congrats @MARIACASTABU, @GermanRick95 , @gerardo_gamba, and @dhekidney

I am very proud to share the publication of our group by German Magaña-Ávila @GermanRick95 commanded by María Castañeda-Bueno @MARIACASTABU, showing the role of NRBP1 and TSC22D in WNK body formation and WNK4-NCC activation. Kudos María! science.org/doi/10.1126/sc…

@TheChungLab The Jacaranda bloom makes me feel like I’m in a Dr. Seuss storybook!

📰 Just published in @JCI_insight insight.jci.org/articles/view/… TL;DR: A new Thick Ascending Limb (TAL) cell classification shows this segment independently regulates: 🔷 Monovalent (Na⁺, K⁺) 🔶 Divalent (Ca²⁺, Mg²⁺) 👀 Fresh lens on TAL 👇

@Catherineoscopy Is the James Beard Award a good sign…or no? I could see it going either way.

@JWNdothelium Garden Grove AND it has a number in the name? It’s a solid start.

I tried the new phở restaurant today. Surprisingly adequate! The family who owns it is so nice. When they asked if it’s California-good. I had to lie. The guy got so excited everyone at my table got a fist bump. 🍜

@Catherineoscopy Ha…calling HEK cells “fibroblasts” is an insult to resident tissue fibroblasts 😜

The most generous interpretation is that he’s talking about fibroblast cells collected in the 1960s… or chick embryos. But wow is that a bonkers leap.

@dr_alphalyrae a.co/d/7nq2I2c

people who can write poetically about science are a gift

@Scholar_Melinda It’s so important to celebrate the submissions! Cocktails/Mocktails with your institutional peers or cheerleaders?

@Catherineoscopy Reminds me when they made mice “like giraffes” (cool study with implications about blood pressure effects on the vascular). Interesting “mammoth mice” weren’t funded by NIH…at least directly. It was a biotech company…that might have used some indirect NIH resources at UTSW.

So stupid, they're not making mice transgender. They're making mice mammoths.

@dr_alphalyrae amazon.com/Accelerated-Si…

Unveiling the secrets of our body's functions, one layer at a time. Learn about wonders of multi-omics - a game-changing approach in #biotechnology. bit.ly/3AEjcP9

@imyourNephBro @OHSUNephrology @dhekidney @imyourNephBro bringing the scRNAseq memes! So proud! Wish I could have been there to cheer you on!

Meet our opening keynote speaker for #APS2025, #NobelLaureate James Rothman! His 2013 #NobelPrize is for groundbreaking research on vesicle trafficking. Rothman will be in Baltimore to kick off the Summit on 4/24/25. Learn more: ow.ly/vpso50U0MT9

Study from @uscpphs found a link between between PFAS (forever chemicals) and kidney damage may be tied to dysregulation of the gut microbiome. @JesseAGoodrich @ResearchAtUSC keck.usc.edu/news/usc-study…

nature.com/articles/s4146… I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are: