Powell Lab

Overall, the identification of these metabolic phenotypes provides insight into the dysfunctional immune response in acutely ill COVID-19 patients and provides a means to predict and track disease severity and/or design metabolic therapeutic regimens. 5/5

Metabolic profiling also revealed MDSCs that expressed elevated CPT1a and VDAC1 in COVID19 and correlated with disease severity. scRNAseq provided clues to their possible function including release of alarmins (S100a8/9) and chemokines (CXCL2/3). 4/5

Our recent paper evaluating #immunometabolism in #COVID19 is officially out @CellReports. Thanks to everyone at @JohnsHopkins and @HopkinsMedicine who helped make this paper a reality! bit.ly/2P37Uvy 1/5

We would like to thank @AnnualReviews for another opportunity to review the exciting field of #adenosine inhibition and ways to improve cancer #immunotherapy. @E_A_Thompson annualreviews.org/doi/10.1146/an…

Proud that our #COVID study is now on @medrxivpreprint. Congrats to @J_Powell_Lab, @Yegnalab, Andrea Cox, Hongkai Ji, and all our collaborators for putting together this impactful study! medrxiv.org/content/10.110…

Excited to share our new #immunometabolism work to define novel immune cells in #COVID19 giving insight into pathogenesis to target metabolism as a treatment! Reach out to hear how we are also using this approach in #immunotherapy @E_A_Thompson medrxiv.org/content/10.110…

A big thank you to Current Opinion in Pharmacology for this opportunity! Excited to share our new review on A2AR as a target for cancer immunotherapy. @RachelSHelms1 & Jonathan Powell identify ways to bring A2AR targeting into the clinic. authors.elsevier.com/sd/article/S14…

Thanks to the editors @NatureRevCancer, excited to have our new review by Leone and Powell posted online. Metabolism of Immune Cells in Cancer. @bobdleone @J_Powell_Lab #immunometabolism nature.com/articles/s4156…

Stay tuned! We are excited to be participating in this wonderful seminar series!

Excited to share our new work in @jclinicalinvest. By targeting glutamine metabolism, we can enhance anti-tumor immunity by modulating MDSCs. jci.org/articles/view/…

@FrontImmunol this builds on previous work from our lab in collaboration with @VCAlabHopkins in @CellReports in 2015, in which we demonstrated combo DON, 2DG, and metformin as metabolic inhibitor therapy was a powerful way to inhibit skin and heart transplant rejection doi.org/10.1016/j.celr…

if you need some non-COVID-19 reading, check out our latest in @FrontImmunol on using metabolic inhibitor therapy in combination with CTLA4Ig in skin and heart transplant to not only prevent rejection, but induce long-term tolerance! doi.org/10.3389/fimmu.…

@RJDLab congrats Ralph! very well deserved!

if you're at the #TRC32020 come by this evening to see Powell lab postdoc Liz Thompson present her work combining flow phenotyping with metabolic markers to predict responses to #Immunotherapy in human peripheral blood samples! poster 7 at 7 (7&7's optional) #immunometabolism

another day, another Powell lab postdoc presenting at #KSTcellmemory! come by the poster session tonight to see Hong Sun (@moonie_sun) present a poster on the role of mTOR regulation of vimentin in the T cell response! memories will be made! #KScellmemory

in Banff for #KSTcellmemory? Get out of the winter chill and stop by the poster session this evening to see our postdoc Chirag Patel present on the role of TSC2 regulation in T cell memory formation!

MetaboList - February 2020 #Metabolism #Immunometabolism metabolist.wordpress.com/2020/03/02/met…

Great start to the T cell memory @KeystoneSymp with a great talk from Rafi Ahmed. Looking forward to tonight's poster session. Swing by poster 1058 to chat about our new project on the impact of metabolic disorders on T cell dysfunction and ACT. #obesetcells #DBRpostdoc