Jacobsen Lab

📢 We’re happy to introduce our first confirmed plenary speaker: Prof. Eric Jacobsen (@JacobsenLab), from Harvard University (@HarvardCCB). We look forward to welcoming you to Gijón!

Part two of special announcements for this year's POCC season! To close out this season, on May 21st we will be celebrating 80 years (!!!) of great seminars with a special symposium featuring multiple speakers including our to-be-selected POCC travel award winner! @JacobsenLab from @HarvardCCB will be our keynote academic speaker and @abbvie 's Eric Voight will be our keynote industrial speaker with @CptingLab from @brandeischem kicking us off as the early career investigator award lecturer. Afternoon appetizers and evening dinner will be provided as well as one-time only POCC swag (while supplies last). Thanks to all our sponsors over this year in helping make this happen! You don't want to miss this one!!!

Tonight, we held our annual Paper of the Year meeting, during which we celebrated the great chemistry published in 2025. This year’s winner was the Stereoretentive Radical Cross-Coupling from @BaranLabReads nature.com/articles/s4158…

Our study on discovering cooperative catalysis is in print @Nature! With @JacobsenLab @eugene_e_kwan @Merck @RichrdLiu we use simple math-based pooling/deconvolution to uncover useful catalyst combinations with minimal experiments Read for free! rdcu.be/eN5i5

🎉 Congrats to Petra @JacobsenLab @HarvardCCB! A notable example of a #flexible approach is a neutral #chiral agent that binds diverse counterions via #HydrogenBonding 🥳🥳 science.org/doi/10.1126/sc… @ScienceMagazine #crystallography 🔬✨

Excited to share our work, now published in JACS, on merging gold and chiral H-bond donor catalysis! Eric Jacobsen and I show that a chiral urea cocatalyst activates an achiral gold catalyst to enable asymmetric spirocyclization of naphthols. @JacobsenLab pubs.acs.org/doi/10.1021/ja…

pubs.acs.org/doi/10.1021/ja… Wonderful new paper from @JacobsenLab ! Metal salens can do it all!

(Salen)Metal-Catalyzed β-Glucuronidation of Alcohols, Phenols, and Anilines | Journal of the American Chemical Society @Harvard @HarvardCCB @JacobsenGroup pubs.acs.org/doi/10.1021/ja…

Meet the Team: Andrew Yue (UIUC BS 2024, now grad student @JacobsenGroup) joined the MCWhite group as a freshman under mentorship of Brenna Budaitis. He merged C(sp3)H/N(sp2) cross-couplings with the Mori-Ban for a diversifiable synthesis of zafirlukast (Accolade).

Presentation of the Roger Adams Award Medal to Prof. Jacobsen (⁦@JacobsenLab⁩ )! ⁦@MaleczkaC⁩ gave an overview of @OrgReactions and The RA Award followed by introduction of Eric by ⁦@JohnWoodGroup⁩. Congratulations Eric! @ACSorganic @OrgSynth #NOS2025

Packed house for @HarvardCCB Eric Jacobsen’s wonderful student-invited lecture on “Privileged Chiral Catalysts.” Thanks for spending your day with @PrincetonChem, Eric!

Many thanks to organicdivision.org and the fabulous Angie @angierangeles for inviting us to the DOC dinner and allowing us to spend a memorable evening celebrating with friends from @JacobsenLab @Stephenson_Lab @SchindlerLab

The University of Chicago Department of Chemistry is honored to welcome Professor Eric Jacobsen, Sheldon Emery Professor of Chemistry at Harvard University, as the distinguished speaker for the Kharasch Lectures on April 1st, 2nd, and 3rd. Prof. Jacobsen's work on asymmetric catalysis, particularly the development of catalysts like those used in the eponymous Jacobsen epoxidation and other widely adopted reactions, has had a profound impact on both academic research and industrial synthesis. His mechanistic insights have also advanced the fundamental principles of catalyst design. The Kharasch Lectures will provide a platform for Professor Jacobsen to share insights from his illustrious career. The lectures will span three days, each focusing on a different facet of his research. For event information and full abstracts, visit our website: chemistry.uchicago.edu/news/renowned-… @JacobsenLab @Harvard @UChicagoPME @UChicagoPSD @UChicagoPME @UChicago @HarvardCCB

Research Highlight now online: Ring-opening of azetidines by @PSeavill nature.com/articles/s4416… ($) Highlighting the @J_A_C_S article by Eric Jacobsen & co-workers @JacobsenLab

Enantioselective Ring Opening of Azetidines via Charge Recognition in Hydrogen-Bond-Donor Catalysis | Journal of the American Chemical Society @Harvard @HarvardCCB @TotalSyntheses pubs.acs.org/doi/10.1021/ja…

Congrats to Joseph @JosephJGair1, Mayuko, Corin & Daniel @JacobsenLab @HarvardCCB 😀😀doi.org/10.1021/jacs.5… @J_A_C_S #crystallography

Have you ever wondered how different substituents affect cation–π vs. π–π vs. CH–π vs. anion–π interactions? Well, now you can read all about it! Very excited to have this work with @Sigman_Lab and @JacobsenLab out in the world @JOC_OL #ACSEditorsChoice

A very exciting study from Jacquelyne Read, Eric Jacobsen, and Matthew Sigman in #JOrgChem: development of a computational library and automated analysis tool for assessing and predicting Noncovalent Interactions (NCIs). Selected for #EditorsChoice go.acs.org/bMV

Iterative Catalyst-Controlled Diastereoselective Matteson Homologations Enables Selective Synthesis of Benzestrol Isomers @Harvard @HarvardCCB #Iterative #Diastereoselective #Matteson #Homologations #Synthesis #Benzestrol @TotalSyntheses @TotalSynthesis pubs.acs.org/doi/10.1021/ja…

Iterative Catalyst-Controlled Diastereoselective Matteson Homologations Enables the Selective Synthesis of Benzestrol Isomers (@J_A_C_S): pubs.acs.org/doi/10.1021/ja… (@JacobsenLab).