Congratulations to Hao, Qing, and all other authors! Very happy to have played my small part in this work.
nature@Nature
Nature research paper: Promiscuous G-protein activation by the calcium-sensing receptor go.nature.com/3Jq3fgp
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Jamie J. Manning
18 posts
Jamie J. Manning
@JamieManning_
GPCR Pharmacology | Postdoc in @Javitchlab @Columbia | PhD @Otago
New York, NY Katılım Haziran 2020
199 Takip Edilen118 Takipçiler
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@JamieManning_ @Nature Thank you Jamie!! Hope all is well with you in NYC!
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I am excited to share our latest research on the arachnoid barrier, a crucial yet poorly understood structure that partitions the CNS and the dura, out today @Nature. We discovered that gaps in this barrier allow communication between the CNS and the dura. nature.com/articles/s4158…
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Jamie J. Manning retweetledi
We are investing $13M toward a new research collaboration with scientists @DukeMedSchool, @ColumbiaMed & @Stanford to expand the collective understanding of G protein-coupled receptors (GPCR), which are vital proteins that impact human health and disease. bit.ly/3Sniwnr
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Jamie J. Manning retweetledi
A Novel “Activation Switch” Motif Common to All Aminergic Receptors #GPCR
pubs.acs.org/doi/10.1021/ac…
@JamieManning_ @JavitchLab
#JCIM Vol63 Issue16 #Review
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Great symposium with excellent speakers, posters, discussion, and venue!
Dr. Nicki Perry-Hauser@NicoleAPerry1
Day 1 was wonderful! Congrats to the GRS speakers and discussion leaders. Ready for Day 2!
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Excited to attend!
Dr. Nicki Perry-Hauser@NicoleAPerry1
The schedule for the GRS in Molecular Pharmacology is live! grc.org/molecular-phar… Please check it out - @BenderSci and I are very excited. Also, if you would like to contribute financially to this event, please use the following link: my.grc.org/p/contribution…
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Jamie J. Manning retweetledi
The @JavitchLab is looking for a new lab manager! nyspi.applicantpro.com/jobs/2767409.h…
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Jamie J. Manning retweetledi
Attention GPCR researchers! This year the GRS/GRC in Molecular Pharmacology will be held from June 10th-16th at Les Diablerets Conference Center in Switzerland. @BenderSci and I are Co-chairs for the Gordon Research Seminar that is dedicated to early-career scientists!
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Some of the work from my PhD is now available! We searched for arrestin2/3 binding motifs in the CB1 c-terminus and found: 1. The pxxp motif isn’t critical for CB1. 2. Both arrestin subtypes require the same sites. 3. There are two functionally distinct phosphorylation clusters.
British Journal of Pharmacology (BJP)@BrJPharmacol
Very nice exploration of the #CB1 phosphorylation sites for #arrestin interaction Authors investigated how different serine/threonine residues within the #CB1 C-terminus affect arrestin2/3 translocation in response to MDMB-FUBINACA Find out more here: doi.org/10.1111/bph.15…
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Jamie J. Manning retweetledi
Our paper “GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision” is out today! We use single-molecule FRET imaging and other biophysical approaches to explore the structural dynamics of β-arrestin1 activation upon binding GPCRs. (1/6)
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Jamie J. Manning retweetledi
Putative SCs MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T-Type Calcium Channel (CaV3) Inhibitors pubs.acs.org/doi/10.1021/ac…
Cool work reporting more (non)-SCRA as modulators of T-type Ca channels ... plenty of potential in a number of different disease states 1/4
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1st annual #ECIGPCR conference so far so good - interesting work being presented. Thanks @NicoleAPerry1 and committee for organising, definitely worth getting up at 1am for!
If anyone wants to know about CB1 motifs for Arrestin binding come see poster 85.
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Jamie J. Manning retweetledi
Happy to see our review on BRET-based biosensors monitoring GPCR activation and pathway selectivity in Current Opinion in Structural Biology alongside many other interesting papers.
sciencedirect.com/science/articl…
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