Jamie Ziggas, PharmD, BCOP

ASTCT Pharmacy SIG Steering Committee have created an FAQ document in regard to the #Fludarabine Shortage for #HCT and #CART Cell Recipients. Log in with your ASTCT account or create an account to access this resource: ow.ly/4KAA50LjjHQ

Hyperinflammatory syndrome resembling HLH following axi-cel & brexu-cel - our small series on HLH-like phenomenon after #CARTcell ⁦@hopkinskimmel⁩ led by Timothy Porter, Ana Lazaveric ⁦@JamieZiggas⁩ ⁦@EphraimFuchs⁩ ⁦@Abbas_Ali2001⁩ onlinelibrary.wiley.com/doi/epdf/10.11…

#tandem22 #oncopharm

So excited to officially present this award to @kczmj at the Pharmacy SIG Awards ceremony tonight! Well deserved @kczmj 👏🏻 👏🏻 👏🏻

@uroosaibrahim @ASTCT @ASTCT_Journal If not in clinic already, triage by phone and admit directly to the unit. Our goal is to keep these patients out of the ED. Anything to add @TaniaJain11 ?

@JamieZiggas @ASTCT @ASTCT_Journal Thanks! Any procedures in place for expedited evaluation when they arrive for suspected CRS? To ED or infusion center or..?

Q1: Is your center administering CAR T therapy in the outpatient setting or do you utilize a hybrid model? What is the inpatient/outpatient split? #ASTCTChat @ASTCT_Journal

#ASTCTChat Looks like outpatient CAR T is the future! Especially given potential use as an earlier line of therapy; and the products in the pipeline #ASH21 @ASTCT @ASTCT_Journal

@uroosaibrahim @ASTCT @ASTCT_Journal Agreed 😊! Patients must reside within 1 hour of the hospital and be able to come to clinic for up to 4 weeks post infusion. No official criteria for admission. All CRS is managed inpatient at this time. #ASTCTChat

@JamieZiggas @ASTCT @ASTCT_Journal That’s amazing! Do patients need to be living close-by? Criteria for admission? Any outpatient management of CRS?

@ASTCT @ASTCT_Journal We admit with Grade 1 or higher CRS. No official criteria established for discharge and up to provider discretion when to send back out for outpatient follow-up. #ASTCTChat

Q4: How are you managing fever/grade 1-2 CRS in the outpatient setting? What set of clinical criteria have centers implemented for admission to the inpatient service; and also what criteria are established for discharge once admitted? #ASTCTChat @ASTCT_Journal

@Arpita_GandhiRX @ASTCT @ASTCT_Journal Patients come to clinic daily for lab work & assessment. If only we could do this virtually- would be the ultimate comfort for the patients! No official “checklist” for when to admit and selection is based on provider’s assessment (frailty, comorbidities, lack of care partner).

@JamieZiggas @ASTCT @ASTCT_Journal That’s amazing. Do patients come to the outpatient clinic for follow up every day or is it done virtually via telemedicine? Is there a screening process to identify patients that may not be ideal candidates for outpatient administration ? @ASTCT @ASTCT_Journal #ASTCTChat

Couldn’t agree more! Additionally, admissions to the inpatient unit for treatment that could be done outpatient keep our services full and create challenges to timely admissions for patients who HAVE to be inpatient. #ASTCTChat #moreresources #cartcell #ambulatorychemo

We can’t wait to kick off our December #ASTCTChat today at 5PM CT! We would like to disclose no COI with the parties involved in this month’s article. Remember to tag @ASTCT and #ASTCTChat to participate! sciencedirect.com/science/articl…

@TaniaJain11 🤣🤣🤣 Difficulty of name!

#ROCKSTAR study- Belumosudil - drugs r competing not only for efficacy, but also difficulty of name and cost 😬 #SOHO2021 @SocietyofHemOnc

Join us for the #meettheprofessor at #SOHO2021 @SocietyofHemOnc @dancourielBMT DrMarcela Maus - we talk about #gvhd #cytopenias after #CART and #longterm follow up after #CART @HopkinsMedicine @huntsmancancer @MGHMedicine

We can’t wait to kick off our May #ASTCTChat today at 6PM CT! We would like to disclose no COI with the parties involved in this month’s article. Remember to tag @ASTCT and #ASTCTChat to participate! astctjournal.org/article/S1083-…

Looking forward to continued discussions on TCT related topics! Thank you to the @ASTCT Content Committee for this opportunity to learn from others across the world. #ASTCTChat

@Patdemartinomd @TheWonkologist As a member of the @ASTCT Pharmacy SIG, we selected this article and developed the questions. Nothing to disclose here either! Our committee found this to be an interesting/relevant topic and wanted to learn from others regarding practices pertaining to defibrotide. #ASTCTChat

Enjoying #ASTCTChat but when ASTCT is using discussion Q like this I wonder if there needs to be financial disclosure given relationship with manufacturer. Especially given real lousy evidence re: efficacy. @TheWonkologist

Excited for the first #ASTCTChat today hosted by the Pharmacy SIG-check it out ☺️

@JamieZiggas welcome to Twitter #PharmTwitter #HAPC

Mark your calendars to participate in our April Twitter chat next Wednesday, April 28! We'll be discussing the article: "Sinusoidal Obstruction Syndrome in Critically Ill Patients in the Era of Defibrotide: A Retrospective Multicenter Study ow.ly/nTv950EttCO