Journal of Cell Biology

Olga D. Jarosińska, Mike Boxem et al. reveal how LGL-1 and PAC-1 team up to polarize the #Celegans embryo, providing new insight into how conserved #polarity mechanisms are adapted across species. hubs.la/Q04fswNZ0 #CellPolarity #Genetics

To find mating partners, #yeast cells use a default #polarity site to assemble a gradient tracking machine, which then redistributes up the pheromone gradient. Pai et al. show that GTM redistribution requires the plasma membrane lipid, phosphatidylserine. hubs.la/Q04fsnVT0

ICYMI: The studies in our #Cancer #CellBiology collection provide new insights into #epigenetic programming or migration of #BreastCancer cells, as well as mechanisms underlying treatment resistance in #leukemia. 👉 hubs.la/Q04bR3-s0

Our May issue is here! hubs.la/Q04flkz80 The cover shows an immunofluorescence image of a #Drosophila midgut acquired w/ an ANDOR Dragonfly 200 microscope. Blue, DAPI (DNA); green, A142GFP (apical membrane); magenta, enteroendocrine cells. Yu et al. hubs.la/Q04flv9l0

Matthew Domenic Lycas, Simon Erlendsson et al. develop a #cryoCLEM workflow to characterize the ultrastructure of dopaminergic varicosities. hubs.la/Q04fhQBb0 #Neuroscience #Organelles #StructuralBiology #Microscopy

Sophie M. Hurwitz, Suzanne Hoppins and colleagues leverage a powerful FRET system to uncover novel insights into the energetic landscape and conformational dynamics of mitofusin, the mitochondrial outer membrane fusion machine. hubs.la/Q04fhZ3H0 #Mitochondria

p62 sorts Lupus La and selected #microRNAs into #BreastCancer-derived #exosomes, from Jordan Matthew Ngo, Randy Schekman and colleagues: hubs.ly/Q04bGv2j0 📕 From our #Cancer Cell Biology 2026 👉 hubs.ly/Q04bJtLQ0

New study by Kronig, Weber, et al. from the Karsten Weis lab (ETH Zurich) shows that a preparatory stress treatment can bypass the requirement for respiration when budding #yeast enter starvation-induced #quiescence hubs.la/Q04f3DQB0 #Biophysics #Metabolism #CellSignaling

Telomeric #SUMO level influences the choices of APB formation pathways and ALT efficiency. From Rongwei Zhao, Huaiying Zhang and colleagues: hubs.ly/Q04bPPdP0 📕 From our #Cancer Cell Biology 2026 👉 hubs.ly/Q04bMcVL0

.@Huveneers_Lab highlights recent work from Mayo et al. (hubs.la/Q04f1ClR0) identifying Scribble as a regulator of endothelial #AdherensJunctions during #angiogenesis. hubs.la/Q04f2dnL0 #Adhesion #Cytoskeleton #Development

New study by Erin Curtis and Aarshi Jain from the Lew lab @MIT shows that the fungal “Cell Wall Integrity” repair pathway is silenced at contact sites between #yeast mating partners to allow cell wall degradation and fusion. hubs.la/Q04f2dTx0 #CellSignaling #Microbiology

#Tetraspanin CD82 shapes #EGFR signaling outcomes through nanoscale receptor organization. From Sebastian Restrepo Cruz, Jennifer M. Gillette and colleagues: hubs.ly/Q04bL5JW0 📕 From our #Cancer Cell Biology 2026 👉 hubs.ly/Q04bP6g90

New study from Bacher et al. @UCBerkeley finds evidence for considerable evolutionary flexibility in the mechanism and regulation of microbial #actin-based #motility. hubs.la/Q04dSbZ60 #Cytoskeleton #Microbiology #Rickettsia

Congratulations to JCB Academic Editor Arshad Desai on his election to @theNASciences. We are proud to have your expertise serving the journal. #NASmembers hubs.la/Q04dTt5Z0

RCC1 depletion drives protein transport defects and rupture in #micronuclei. From Molly G. Zych, Maya Contreras, Anna E. Mammel, and Emily M. Hatch: hubs.la/Q04bRLq40 📕 From our #Cancer Cell Biology 2026 👉 hubs.la/Q04bQJXb0

We had a chance to write a Spotlight article about the recent publication by Rongwen Xi et al. in J Cell Biol! @JCellBiol This interesting work uncovers the genetic mechanism that controls open or closed type EE morphology in the Drosophila midgut. 🪰

Douglas W. DeSimone, Sophie Astrof, and Martin A. Schwartz pay tribute to Richard O. Hynes, whose passing in January is a great loss to science and an even greater loss to his many friends, students, and colleagues. hubs.la/Q04dNc340 #InMemoriam

LncRNA EGFR-AS1 promotes DNA damage repair by enhancing PARP1-mediated PARylation, say Kun Gao, Changying Guo (Xinjiang University), Liang Jin (China Pharmaceutical University) et al.: hubs.la/Q04bPjC20 📕 From our #Cancer Cell Biology 2026 👉 hubs.la/Q04bRg9j0

Read An interkinetic envelope surrounds chromosomes between meiosis I and II in C. elegans oocytes rupress.org/jcb/article/22…

“We were thrilled and deeply honored that our paper was selected as one of JCB’s most influential papers of 2025 in the Year in Cell Biology.” — Julien Dumont. JCB is where the world meets your research. Learn more. hubs.ly/Q04dbxvm0