Yojet Sharma

Neurons carry ~5,000–10,000 molecules of PI(4,5)P₂ per μm² of membrane (Bertil Hille, 2001). What happens to human brain development when that number changes? I address this in my PhD work using a disease-in-a-dish model of Lowe Syndrome: embopress.org/doi/10.1038/s4…

@CellCellPress @EMBOPress Molecular System Biology March 2023 issue was Klimt inspired.

New issue alert👉cell.com/cell/current Yoshida et al. present 3D, single-cell-resolution atlases of multiple adult mouse organs and of the entire neonatal mouse. The artwork reimagines Klimt's decorative motifs to reflect the organization and vast scale of individual cells.

@XiangWu96 Very fun informal title!

Very excited to share my postdoc work "A song of ice (calcium) and fire (voltage) in neuronal dendrites", or if you prefer the formal title, "A dendrite-resolved, in vivo transfer function from spike patterns to dendritic Ca2+", biorxiv.org/content/10.648…

Excited to share our new study identifying soluble DLK1 as a novel microglia-derived senescence factor. sDLK1 induced hypomyelination, oligodendrocyte dysfunction, & altered neuronal activity in iPSC-derived neurons @TheodorisLab @dsrivastava_md biorxiv.org/content/10.648…

I am excited to share our new paper, where we developed and used a new approach that allows us to dynamically monitor autophagy in the intact mouse brain! biorxiv.org/cgi/content/sh…

#ResearchExplained In a recent study @JetYojet & team from Prof @RPadinjat's lab have discovered a spike in a certain lipid in the brain linked to breakdown of smooth neuronal communication in patients diagnosed with Lowe Syndrome(LS) Read: bit.ly/44iQUW6 ✏️@LittleMurthy

This topic probably flies under the radar for most neuroscientists, but this paper is a big deal science.org/doi/10.1126/sc…

A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy: Neuron cell.com/neuron/fulltex…

Non-canonical roles of lysosomes in neurons cell.com/trends/neurosc…

Our collaborative paper (nature.com/articles/s4146…) with Taka's lab is out. His lab was the major driving force behind this. A combination of synthetic dyes and self-labelling tags allows visualisation and quantification of extracellular versus intracellular receptors.

Happy to share new research in EMBO Molecular Medicine (doi.org/10.1038/s44321…) from our group that reveals the underlying causes for the brain manifestations of Lowe syndrome, a rare genetic disorder affecting young boys. (1/n)

Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome | EMBO Molecular Medicine. Congrats @RPadinjat @NCBS_Bangalore embopress.org/doi/full/10.10…

🧠 Publication Alert! @JetYojet and team from @RPadinjat 's lab uncover how enhanced Notch-dependent gliogenesis and delayed maturation underlie neurodevelopmental defects in Lowe syndrome. Read the paper 👉 doi.org/10.1038/s44321… Congratulations to the team! 🎉

@ventigers Thanks Venkat!

@JetYojet Congratulations Yojet!

Neurons carry ~5,000–10,000 molecules of PI(4,5)P₂ per μm² of membrane (Bertil Hille, 2001). What happens to human brain development when that number changes? I address this in my PhD work using a disease-in-a-dish model of Lowe Syndrome: embopress.org/doi/10.1038/s4…

📢 Publication alert ! #LoweSyndrome is a rare #genetic disorder affecting the eyes, kidneys & the brain. Team @cbmncbs has the first ever insightful findings into the brain defects with a potential to redesign therapy. 1/n

@cbmncbs @RNP_Foundation @DBTIndia @RPadinjat @gaganaorsky Many thanks to the Lowe Syndrome Patients for participating, @cbmncbs @RNP_Foundation @DBTIndia @NCBS_Bangalore, my PI @RPadinjat, and @gaganaorsky, Sankhani & Priyanka! (Video above shows: Ca imaging in 90 day old iPSC-derived neurons and brain organoid derived astrocytes.)

@cbmncbs @manotsavaindia @cbmnimhans @arpan_parichha @hiyaa_ghosh @PrabahanChakra @SRM_Univ @JetYojet from NCBS presents findings on Notch- driven gliogenesis & delayed maturation in Lowe syndrome @cbmncbs @cbmnimhans @manotsavaindia #Manotsava2025 #NCBS #HappeningNow

@mbeisen But don’t you think that giving him and the others like him the benefit of the doubt because of his generation leaves a room for other people to continue the same path? Jeremy Berg gave a tutorial about him on Bluesky which sounds like “he was a horrible person but that’s ok”.

What he did was unethical, by the standards of any era. The data W&C saw of hers clearly influenced their thinking, and gave them confidence in their model. But she had not worked out the correct structure of DNA, and doesn't seem to haver been on the precipice either. While she might have ultimately worked it out directly from experimental data, as she wanted, I think it's likely that someone else would have deduced it earlier. It's not like this work was going on in secret - they were talking about it fairly openly and the basic outlines of their experimental findings were known. I'm in no way trying to defend Watson and Crick (and others) in this - their choice to downplay her role in the discovery warrants opprobrium. But the way this is often talked about is that she had - or was about to at least - solve the structure of DNA, and I don't think that's right, although of course, we can't really ever know.

The right way to remember Jim Watson is to remember him honestly. He was a central figure in one the 20th century's most impactful scientific discoveries, in the creation of modern molecular biology, in the beginning of the genomics era, and (less notably) to shaping the structures of contemporary academic departments and institutions. His actions with respect to Rosalind Franklin are certainly not beyond reproach, but the reduction of him in many peoples' minds to someone who stole her discovery is unfair and does little service to the truth. He could be charming and insightful in person, but also quick to demean people around him for seemingly no other reason than that he could. He spoke out frequently against unscientific thinking, yet also frequently said things that were unambiguously - and it often seemed intentionally - sexist, racist and anti-Semitic. The talk I saw him give at Berkeley 20 ish years ago, while perhaps designed primarily to provoke, was a masterclass in how to undermine your own reputation as a person and a thinkier. His demise was sad, but also self-inflicted in a way that someone as smart as he thought he was should have known to avoid. I know many won't mourn him - and that is fine - but I will because I think he and his generation of scientists made science a more interesting - if not always a better - place.

@mbeisen An uninteresting science is better than a bad toxic workplace to be at surely.