SunLab
443 posts
SunLab
@JiSunLab
The Sun Lab | Structural Biology @ St Jude
Katılım Eylül 2019
308 Takip Edilen656 Takipçiler
Excited to share our new manuscript! Why do people with Bosma #arhinia microphthalmia syndrome (BAMS) not form noses? We show that #iPSCs from these patients are less able to form cranial placode cells, one of the cell types that make up the nose. cell.com/stem-cell-repo…
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Scientists led a multi-institute collaboration to create PanNDA, a first-of-its-kind atlas mapping proteomes across six neurodegenerative diseases and more than 10,000 brain proteins. PanNDA can be used as a resource to advance diagnosis and treatment. ow.ly/Yk9N50YxEXN
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Excited to share our lab's latest discovery today in @Nature: "orthosteric molecular glue” (OMG) inhibitors - a new drug design strategy that achieves substrate-dependent potency, i.e., substrate selectivity, with conventional orthosteric inhibitors. rdcu.be/e3waV
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Happy to share our new publication on KCNQ1. In this work, we reveal a cool molecular mechanism that modulates the tissue-specific function of KCNQ1 through its beta subunits, KCNE1/3, which provides different voltage and PIP2 (GPCR) sensitivity for gating nature.com/articles/s4142…
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fitting that my PECASE certificate finally arrived many months late and looking worse for wear (much like me these days😂😭). Still grateful to the Biden admin. for recognizing the importance of junior investigators in science❤️
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A new paper from the #MacKinnonLab in @PNASNews finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience
pnas.org/doi/10.1073/pn…
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...and big thanks to @janetiwasa for making this amazing video to illustrate the strand-sliding mechanism!
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Excited to share our new @ScienceMagazine paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
science.org/doi/10.1126/sc…
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Our researchers, in collaboration with the Medical College of Wisconsin, have discovered how chemokines and G protein-coupled receptors (GPCRs) selectively bind to control how cells move. ow.ly/77Yl50VGpKe
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Congratulations 🎉, @JunminPengLab
Structural Biology at St. Jude Children's Hospital@StJudeStructBio
Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: cell.com/cell/fulltext/… Explore this amazing resource here: yslproteomics.shinyapps.io/tissuePPT
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Nature research paper: VDAC2 loss elicits tumour destruction and inflammation for cancer therapy
go.nature.com/41AWsZX
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Complex water networks visualized by cryogenic electron microscopy of RNA, done by @RDasLab, @kaiming_zhang, @chiulab
nature.com/articles/s4158…
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Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more:nature.com/articles/s4146…
@JunminPengLab @Yanshen73854711 #proteomics #MassSpec #Proteinturnover #Alzheimers
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Congratulations 🎉 to @LabZheng for the two back-to-back stories on UM171 molecular glue. nature.com/articles/s4158…;
nature.com/articles/s4158…
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Interesting work from @TheHurleyLab
The Science of Parkinson's@ScienceofPD
New research from @TheHurleyLab & @ASAP_Research collaborators describes a structural pathway of enzyme activation (determined via cryo-EM analysis) of phosphatidylinositol-3 kinase complexes I (PI3KC3-C1) by VPS15 in autophagy science.org/doi/10.1126/sc…
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I am excited for this opportunity to chair the Department of Biochemistry and Biophysics at Weill Cornell Medicine! news.weill.cornell.edu/news/2025/01/d…
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congratulations, Christoph.
Structural Biology at St. Jude Children's Hospital@StJudeStructBio
Congrats to our newest faculty member, Christoph Gorgulla @StJudeResearch, and colleagues @UofT @InSilicoMeds, for work just out @NatureBiotech — using quantum computing to design small molecules that inhibit KRAS. #OpenAccess nature.com/articles/s4158…
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