SunLab
443 posts
SunLab
@JiSunLab
The Sun Lab | Structural Biology @ St Jude
Katılım Eylül 2019
308 Takip Edilen655 Takipçiler
Excited to share our new manuscript! Why do people with Bosma #arhinia microphthalmia syndrome (BAMS) not form noses? We show that #iPSCs from these patients are less able to form cranial placode cells, one of the cell types that make up the nose. cell.com/stem-cell-repo…
English
SunLab retweetledi
Scientists led a multi-institute collaboration to create PanNDA, a first-of-its-kind atlas mapping proteomes across six neurodegenerative diseases and more than 10,000 brain proteins. PanNDA can be used as a resource to advance diagnosis and treatment. ow.ly/Yk9N50YxEXN
English
SunLab retweetledi
Excited to share our lab's latest discovery today in @Nature: "orthosteric molecular glue” (OMG) inhibitors - a new drug design strategy that achieves substrate-dependent potency, i.e., substrate selectivity, with conventional orthosteric inhibitors. rdcu.be/e3waV
English
Happy to share our new publication on KCNQ1. In this work, we reveal a cool molecular mechanism that modulates the tissue-specific function of KCNQ1 through its beta subunits, KCNE1/3, which provides different voltage and PIP2 (GPCR) sensitivity for gating nature.com/articles/s4142…
English
fitting that my PECASE certificate finally arrived many months late and looking worse for wear (much like me these days😂😭). Still grateful to the Biden admin. for recognizing the importance of junior investigators in science❤️
English
SunLab retweetledi
A new paper from the #MacKinnonLab in @PNASNews finds that while Kv2.1 and EAG1 are from distinct architectural classes of voltage-dependent ion channels, the way the voltage sensors gate their pores is very similar. #RockefellerScience
pnas.org/doi/10.1073/pn…
English
...and big thanks to @janetiwasa for making this amazing video to illustrate the strand-sliding mechanism!
English
Excited to share our new @ScienceMagazine paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
science.org/doi/10.1126/sc…
English
SunLab retweetledi
Our researchers, in collaboration with the Medical College of Wisconsin, have discovered how chemokines and G protein-coupled receptors (GPCRs) selectively bind to control how cells move. ow.ly/77Yl50VGpKe
English
Congratulations 🎉, @JunminPengLab
Structural Biology at St. Jude Children's Hospital@StJudeStructBio
Beautiful work from @JunminPengLab and @Yanshen73854711 in @CellCellPress Turnover atlas of proteome and phosphoproteome across mouse tissues and brain regions: cell.com/cell/fulltext/… Explore this amazing resource here: yslproteomics.shinyapps.io/tissuePPT
English
SunLab retweetledi
Nature research paper: VDAC2 loss elicits tumour destruction and inflammation for cancer therapy
go.nature.com/41AWsZX
English
SunLab retweetledi
Complex water networks visualized by cryogenic electron microscopy of RNA, done by @RDasLab, @kaiming_zhang, @chiulab
nature.com/articles/s4158…
English
SunLab retweetledi
Excited to share our new paper! We mapped proteomic changes in AD models, revealing shared pathways with human AD and delayed protein turnover in amyloid plaques. Read more:nature.com/articles/s4146…
@JunminPengLab @Yanshen73854711 #proteomics #MassSpec #Proteinturnover #Alzheimers
English
Congratulations 🎉 to @LabZheng for the two back-to-back stories on UM171 molecular glue. nature.com/articles/s4158…;
nature.com/articles/s4158…
English
Interesting work from @TheHurleyLab
The Science of Parkinson's@ScienceofPD
New research from @TheHurleyLab & @ASAP_Research collaborators describes a structural pathway of enzyme activation (determined via cryo-EM analysis) of phosphatidylinositol-3 kinase complexes I (PI3KC3-C1) by VPS15 in autophagy science.org/doi/10.1126/sc…
English
Congratulations, Chunyi!
Chunyi Hu Lab@Chunyi_Hu1
🚀 Thrilled to announce our latest work published in @NatureComms ! NAPTUNE: An ultra-sensitive platform using APE1 to create 5'-phosphorylated DNA, which guides PfAgo for precise nucleic acid & protein detection. 🔗 nature.com/articles/s4146… #Diagnostics #PfAgo #NucleicAcids
Indonesia
I am excited for this opportunity to chair the Department of Biochemistry and Biophysics at Weill Cornell Medicine! news.weill.cornell.edu/news/2025/01/d…
English
congratulations, Christoph.
Structural Biology at St. Jude Children's Hospital@StJudeStructBio
Congrats to our newest faculty member, Christoph Gorgulla @StJudeResearch, and colleagues @UofT @InSilicoMeds, for work just out @NatureBiotech — using quantum computing to design small molecules that inhibit KRAS. #OpenAccess nature.com/articles/s4158…
English