


Joe Y Chang
527 posts

@JoeChangMD
Endowed Texas 4000 Distinguished Professor and Director, Stereotactic Ablative Radiotherapy Program, MD Anderson Cancer Center




Research summary here: jamanetwork.com/journals/jama/…











A sincere appreciation and acknowledgment to the 440 patients, investigators, and institutions who participated on this Phase III randomized trial highlighting the ability of proton therapy (IMPT) to de-intensify treatment and improve survival @MDAndersonNews





A new publication from @BrendanHeiden et al demonstrates an OS benefit for patients with stage I NSCLC undergoing surgery at VA medical centers with on-site SBRT. The results show that SBRT is being appropriately leveraged to optimize patient selection when available. These data provide further evidence that MDT matters. @ZaidAbdelsattar @kelleymic academic.oup.com/jncics/advance…

Shocking! Only 1.4% of global cancer spend is used for surgical research and only 2.8% on radiotherapy research. Please help us learn how to cure more patients by funding curative therapies research! #radonc

💥 “Screen or not to screen?” After 23 years, ERSPC finally answers. 📊 ERSPC (n = 162,236 men, 55–69 yrs) 🔹 Screening: repeated PSA testing 🔹 Control: no screening ⏱️ Median follow-up: 23 yrs 🎯 Results 🧬 ↓ Prostate cancer mortality: 1.4% vs 1.6% (RR 0.87 [0.80–0.95]) ➡️ 13% relative & 0.22% absolute risk reduction 📈 NNI = 456 | NND = 12 → better harm–benefit ratio ⚠️ Overdiagnosis: +27 extra cases / 1000 men (mostly low-risk) 🧩 Who should be screened? ✅ Men 50–69 y with ≥15 y life expectancy ✅ Earlier (40–45 y) if BRCA2+, family history, or African ancestry 🚫 Stop if >70 y, frail, or PSA < 1 ng/mL at 60 y 💡 Takeaway: PSA screening saves lives - just not everyone’s. Target the right men, at the right age, using risk-based + MRI-guided screening. 📖 Roobol MJ et al. NEJM 2025 🔗doi.org/10.1056/NEJMoa… #OncoTwitter #MedTwitter #ProstateCancer #Screening #ESMO25 @OncoAlert @myesmo @esmo_open @ASCO @NEJM @Uroweb @AmerUrological @UrologyTimes @EUplatinum


🚨Our new paper is out today in Nature! We show that SARS-CoV-2 mRNA vaccines can sensitize tumors to immune checkpoint blockade (ICI) — revealing that clinically available RNA vaccines may act as potent immune modulators. nature.com/articles/s4158…

#ESMO25 PAULIEN trial: 🔍 First randomized head-to-head trial of 1L pembro ± chemo in PD-L1 ≥ 50% NSCLC 🔹 Stopped early for futility — no added benefit from chemo 💬 Response by tumor burden, metastatic sites, and molecular subtypes remains unclear.








