Joe Ecker

@Dinnenylab @Edel_PLopez @NaturePlants Thanks Jose

@JoeEcker @Edel_PLopez @NaturePlants Innovative experimental design and analysis! Glad to see this out!

🌿 New paper from the lab out in @NaturePlants! We built a single-cell atlas of Arabidopsis leaf development to ask: how does drought reshape leaf gene expression at the cellular level? doi.org/10.1038/s41477… 🧵

@Marand_Lab @NaturePlants Thanks Alex

@JoeEcker @NaturePlants What a cool study! Congrats to Joseph and the whole team

Advances in plant spatial multi-omics data analysis cell.com/trends/plant-s… ♻️

New OA Article: "Stress drives plasticity in leaf ageing transcriptional dynamics in Arabidopsis thaliana" rdcu.be/e80cP Single-nuclei atlas. Drought advances leaf maturation in a dose-dependent manner. Mesophyll-specific FRO6 overexpression partially restores growth.

Congrats to lead author Joseph Swift and the team: Xuelin Wu, Jiaying Xu, Carl Procko, Tanvi Jain, Natanella Illouz-Eliaz, Joseph Nery, and my dear departed colleague Joanne Chory @SalkInstitute @HHMINews Data: GEO GSE290214 Atlas:neomorph.salk.edu/SCMDAP/LeafDev… neomorph.salk.edu/ecker-website/

This led us to FRO6 (FERRIC REDUCTION OXIDASE 6) — a mesophyll gene repressed by drought. Overexpressing FRO6 specifically in the mesophyll partially restores leaf growth under drought, without affecting well-watered plants. 🌱

Epigenetics News - What changes happen in the aging brain? bit.ly/3Pcyth9 An atlas of cell type-specific epigenetic changes occurring in the aging mouse brain aims to better understand neurodegenerative disease #Epigenetics #News #Aging --- epigenometech.com

@ssun_1116 @NVIDIAHealth @HongkuiZeng @JoeEcker @gracexyzheng @Deto128 @perturbai_tx @XinheZheng Thank you @anthonycosta for the lovely talk and the shoutout during today’s @NVIDIAGTC keynote! A small peek as we march through the breathtaking neuronal cytoarchitectural diversity in vivo - h/t @BoliWu

Led by amazing Tuo Shi, Maria Korshunova, @ssun_1116 + enabling collaborators Laksshman Sundaram, TJ Chen (@NVIDIAHealth), Stephan Sanders, @HongkuiZeng @JoeEcker @gracexyzheng @Deto128 @PerturbAI_tx. I’m so lucky and grateful to have built this with you together.

We’re excited to share that the manuscript detailing PerturbAI’s largest brain-wide in vivo CRISPR atlas is now live on bioRxiv. The work reveals insights into the genetics and mechanisms of diseases in vivo, paving the way for novel therapeutic discovery grounded in human genetics and causal biology. This important milestone follows our launch from stealth yesterday, with the public release of our landmark dataset to accelerate biology and medicine. Read the manuscript here: biorxiv.org/content/10.648… #CRISPR #AI #DrugDiscovery #FunctionalGenomics #Biotech

📢 Preprint: we present a whole-mouse-brain in vivo Perturb-seq atlas, 7.7 million cells, 1947 disease-associated perturbations, moving toward direct readout of how human genetics rewires cell states & circuits in vivo. Grateful for the Team! @NVIDIAHealth biorxiv.org/content/10.648…

🧩 Can you guess who will join us as a guest artist for the 30th annual Symphony at Salk in August? One half of this mystery duo is an Emmy-winning composer who won for his original score for the television miniseries The Kennedys. 🎼 For decades, he’s written music for film and television—and when he’s not composing, he’s on stage performing with his brother in their Americana-rock band. Think you know who the duo is? Drop your guesses below. 👀 Every year, Symphony at Salk welcomes an artist to perform alongside the San Diego Symphony on Salk’s campus to raise money directly for Salk science. Last year’s event sold out—mark your calendar now and be ready when tickets go on sale! symphony.salk.edu

Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq | bioRxiv | from Prof. Xin Jin's lab @xinjin @hhmi_science @nvidia @scrippsresearch biorxiv.org/content/10.648…

Introducing PerturbAI. Today we announced our emergence from stealth with the release of the world’s largest in vivo CRISPR data engine, interrogating the effects of thousands of genetic perturbations across 8 million cells throughout the whole brain. This dataset represents a new category of biological data: organism-level, circuit-resolved causal genomics leading to novel targets and therapeutics. By combining scalable in vivo CRISPR perturbation with AI, we model biological systems at unprecedented resolution and simulate therapeutic interventions before committing to expensive downstream development. We’re grateful to our collaborators at @NVIDIAHealth and @10xGenomics for helping make this landmark dataset possible. Read More: perturb.ai/news #CRISPR #AI #DrugDiscovery #FunctionalGenomics #Biotech

From Prof Jin and my colleagues @scrippsresearch the largest in vivo CRISPR data engine, nearly 8 million cells, in collaboration with @nvidia and featured at GTC

Today, I am thrilled to introduce @PerturbAI_Tx, a company I co-founded to rethink drug discovery. Biology is complex, and disease unfolds across genes, cell types, and tissues. We’re powering AI with the causal logic of human genetics: perturb.ai

Excellent post by Rachel Thomas in the ways AI hype is outrunning reality in life sciences linkedin.com/feed/update/ur…