Ryan Edwards
2.3K posts

Ryan Edwards
@JokesOnAI
I spend most of my time turning the lights off (4 kids). Trying to build an empire.

“Stop Ozempic and you’ll regain everything.” 7,938 real-world patients say otherwise. @ClevelandClinic just published the largest GLP-1 discontinuation study to date. Patients treated for obesity lost 8.4% of body weight before stopping. One year later, average rebound: 0.5%. Not 50%. Not “most of it.” Half a percent. 45% maintained or kept losing weight after discontinuation. For diabetes patients, it’s even more striking: they lost an additional 1.3% AFTER stopping. What did people do instead? 27% switched medications. 20% restarted later. 14% pursued lifestyle changes with a clinician. Less than 1% had bariatric surgery. The clinical trial narrative (“you’ll regain more than half”) doesn’t match real-world behavior. People don’t just stop and go back to their old lives. They adapt. n=7,938. Real patients. Real follow-up. Not a controlled trial where stopping the drug means stopping all support.


I’m so serious, retatrutide has made me genuinely unable to eat anything but vape and ice cream. I can’t stomach more than a few bites of anything else but I’m about to go back for a second scoop of ice cream


People who quit taking popular GLP-1 drugs such as Ozempic might their jeopardize heart health, according to a new study. usatoday.com/story/money/20…


















