Jon Read

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Jon Read

Jon Read

@JonRead15

Infectious disease epidemiologist, fascinated by networks, transmission, pathogen evolution & our responses.

Lancaster University, UK Katılım Ocak 2020
202 Takip Edilen2.7K Takipçiler
Andrew McCarthy
Andrew McCarthy@AJamesMcCarthy·
I took 1.7 million photos over 6 days to catch this photo of a commercial jet in front of the sun. The moment it happened, TWO floating prominences were visible, making this not just my best aircraft transit photo, but one of the luckiest of my career! Videos of the transit 👇
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Jon Read
Jon Read@JonRead15·
@PaulNuki @AlisonTerf71r Or indeed HIV, ebola (post-mortem transmission common due to cultural practices), or anthrax in wildlife. There is no 'rule'.
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Paul Nuki 🦋
Paul Nuki 🦋@PaulNuki·
@AlisonTerf71r No, i'm using it to illustrate that there is no rule which dictates that viruses which spread efficiently are necessarily mild. Think smallpox, Influenza, measles, typhus, bubonic plague, and malaria to mention but a few
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Paul Nuki 🦋
Paul Nuki 🦋@PaulNuki·
Tell this ‘simple rule’ to the Black Death…
Anish Moonka@anishmoonka

Three people just died of hantavirus on a Dutch cruise ship. The strain kills nearly 40% of the people it infects. And yet no virologist on earth is panicking about a pandemic, because the reason it stays small is one of the strangest rules in disease science. The rule is simple. The deadlier a virus is, the harder it is to spread. If a virus kills you in days, you can't ride a bus, board a plane, or even leave the hospital. You're in a bed or a body bag. Either way, the virus killed its only ride. Hantavirus has been around for at least 70 years, but fewer than 1,000 Americans have ever caught it. The CDC says it kills 38% of those who do. The cruise ship strain, called Andes, kills closer to 40%. If hantavirus spread like COVID, it would kill billions. But it can't. Most hantaviruses spread only one way. You breathe in tiny dust particles from rat or mouse pee, droppings, or spit. No mice in your house, no virus. The cruise ship is the rare exception, because the Andes strain can spread between people, but it usually needs close contact like spouses sharing a bed. A Johns Hopkins virologist called Andes spread "unbelievably rare." Compare it to the viruses that scared the world. Ebola kills 60 to 90% of people, but only through bodily fluids and only late in the illness, so each patient passes it to fewer than 2 others. SARS killed 10% before being wiped out in 8 months. MERS killed 35% but never spread far beyond the Middle East. None of them became pandemics, because the spread was always too slow. Then COVID showed up. It killed about 1 in every 100 people who caught it. That is almost nothing compared to hantavirus. But COVID was mild enough that you could work for a week without knowing. You would ride the bus, hug your kid, eat lunch with a coworker, and infect four other people. It killed 7 million. Flu works the same way. Mild fever, sore throat, but you still drag yourself to school or the office. The virus walks right into the next host. Hantavirus is the opposite. Within 4 to 10 days, your lungs fill with fluid. There's no medicine that fights it and no vaccine to prevent it. The only treatment is a machine that breathes for you, and even that just cuts the death rate from 50% to 20%. Every outbreak, from 3,200 UN soldiers in the Korean War, to the 1993 Four Corners cases, to Gene Hackman's wife Betsy Arakawa last year, traces back to mice. The viruses that worry scientists are the boring ones. The ones that give you a sniffle for a week and let you walk around the city while you're contagious. Hantavirus, brutal as it is, never had the spread to do real damage.

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Jon Read
Jon Read@JonRead15·
@PaulNuki It'll be kettles next, and then there will be no going back.
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Jon Read
Jon Read@JonRead15·
@alexcdot @GoogleDeepMind @Meta @MIT @Cambridge_Uni You can't blame peer review entirely, the principal blame lies with the supervisors and PIs that either (a) allow use of genAI in this way or (b) fail to read their own papers carefully!
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Alex Cui
Alex Cui@alexcdot·
Okay so, we just found that over 50 papers published at @Neurips 2025 have AI hallucinations I don't think people realize how bad the slop is right now It's not just that researchers from @GoogleDeepMind, @Meta, @MIT, @Cambridge_Uni are using AI - they allowed LLMs to generate hallucinations in their papers and didn't notice at all. It's insane that these made it through peer review👇
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Eric Topol
Eric Topol@EricTopol·
Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts 1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below
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Michael Levin
Michael Levin@drmichaellevin·
A new, long paper on evolution - natural induction - split into 2: royalsocietypublishing.org/rsfs/article/1… royalsocietypublishing.org/rsfs/article/1… @RichardWatson90 and Tim Lewens "It is conventionally assumed that all evolutionary adaptation is produced, and could only possibly be produced, by natural selection. Natural induction is a different mechanism of adaptation. It occurs in dynamical systems described by a network of interactions, where connections give way slightly under stress and the system is subject to occasional perturbations. This differential adjustment of connections causes reorganization of the system’s internal structure in a manner equivalent to associative learning familiar in neural networks. This is sufficient for storage and recall of multiple patterns, learning with generalization and solving difficult constraint problems (without any natural selection involved). Various biological systems (from gene-regulation networks to metabolic networks to ecosystems) meet these basic conditions and therefore have potential to exhibit adaptation by natural induction. Here (and in a follow-on paper), we consider various ways that natural induction and natural selection might interact in biological evolution. For example, in some cases, natural selection may act not as a source of adaptations but as a memory of adaptations discovered by natural induction. We conclude that evolution by natural induction is a viable process that expands our understanding of evolutionary adaptation."
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Jon Read
Jon Read@JonRead15·
@LongCovidHell It's common for most health systems to do further PCR tests to determine type/subtype of influenza (H1N1,H3N2,B), and anything that is negative for those would be investigated further particularly if causing severe disease. This is how most human avian influenza are picked up.
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Dame Sa 🐝 3.5%
Dame Sa 🐝 3.5%@LongCovidHell·
Sorry if this is a stupid question, but given how unusually severe flu is this year across the world, and they’re testing positive for influenza A… Could this be bird flu? Bird flu is A, isn’t it? Are hospitals specifically testing for avian flu or just flu?
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Adam Kucharski
Adam Kucharski@adamjkucharski·
Turns out interest in metaverse had about a ~9 month half life.
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Andrew McCarthy
Andrew McCarthy@AJamesMcCarthy·
Immense planning and technical precision was required for this absolutely preposterous (but real) view: I captured my friend @BlackGryph0n transiting the sun during a skydive. This might be the first photo of it's kind in existence. See a video of this moment in the reply 👇
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Marc Johnson
Marc Johnson@SolidEvidence·
Help me out, I’ve got another wastewater virus mystery. This one really blows my mind. 1/
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mark littlejohn
mark littlejohn@mark_lj·
Looking left and right this afternoon.
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Jon Read
Jon Read@JonRead15·
@BuDs_UK How are you estimating the community prevalence?
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BuDS Disability Service
As of 5 October, around 1 in every 111 people in England were infected, and the risk of encountering an infected person in most indoor places remains High. Unless the indoor air is fresh, or filtered/purified, good quality PPE respiratory masks are needed to protect yourself.
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BuDS Disability Service
The Covid wave in England continues to grow, with infection levels up 11% in the last week. The risk level is hovering just below Very High. If you do not wish to catch Covid, please take precautions including getting boosted now. buds.org.uk/covid-19-risk-…
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Cliff Hands
Cliff Hands@CHPhotography15·
Cul Mor, northwest highlands, Scotland.
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Les Dawson's Sid James Freakout
If this government push through legislation to sell off allotments there should be a counter movement to re-wildlife golf courses. it's only fair.
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Claudio Fronterre
Claudio Fronterre@ClaudioFronterr·
🚨 Workshop Alert at #RSS2025 📅 Tues 2 Sept, 14:00–16:00 🗺️ Model-based Geostatistics for Public Health in R With Emauele Giorgi & myself Learn to go from spatial data to predictions with RiskMap using real case studies. 👉 rss.org.uk/training-event… #RStats #Geostat
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Thunder Chicken
Thunder Chicken@TheTimidToucan·
@vipintukur I need to see more than 10 people in the experimental group. Show me 300 and then I’ll pay attention.
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Vipin M. Vashishtha
Vipin M. Vashishtha@vipintukur·
A common virus once thought harmless to humans might be linked to Parkinson's disease, a new study says. The germ, Human Pegivirus (HPgV), was found in half the autopsied brains of patients with Parkinson's, but not in any brains from healthy people. 1/
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Jon Read
Jon Read@JonRead15·
@DrCJ_Houldcroft Extremely interesting, and useful knowledge, but what a strange study. The subjects must be known to, related to, or are paper authors?
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Dr Charlotte Houldcroft
Dr Charlotte Houldcroft@DrCJ_Houldcroft·
What a gem this paper is journals.asm.org/doi/full/10.11… Healthy infants, breastfed, no travel, no daycare, shed enteric viruses *nearly every day* from ~100-400 days of life! Children catch enteric viruses ALL the time and often show no symptoms of infection. Hard to stop transmission.
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Marc Johnson
Marc Johnson@SolidEvidence·
This is cool. I was poking around at the Rhinovirus (common cold) data and realized that my perception about these viruses was completely wrong. 1/
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Antonia Ho
Antonia Ho@DrToniHo·
Many thanks to @CEPHR_UCD for inviting me to give a seminar on my group’s work at @CVRinfo! 🦠🫁🧬🏥
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