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Joseph DeSimone
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Joseph DeSimone
@Joseph_DeSimone
Prof @Stanford; Founder: @PinPrint, @Carbon, @FocalMedical, @Solid_Battery, @Liquidia_Inc, BVS; Trustee: @UrsinusCollege (Chair, BOT), @NatGeo | La vita è bella
Katılım Ağustos 2011
2.5K Takip Edilen9.3K Takipçiler
Great visit from @kellehersan to our group at @Stanford—her seminar “What we talk about when we talk about Love [Chemistry]!” was equal parts science and soul.
Grateful too for the gift of 100 Poems—a perfect reminder that chemistry, like poetry, is about connection.
Wore green in her honor ☘️—felt only right to welcome Dublin to Stanford.
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Joseph DeSimone retweetledi
The math on this project should mass-humble every AI lab on the planet.
1 cubic millimeter. One-millionth of a human brain. Harvard and Google spent 10 years mapping it. The imaging alone took 326 days. They sliced the tissue into 5,000 wafers each 30 nanometers thick, ran them through a $6 million electron microscope, then needed Google’s ML models to stitch the 3D reconstruction because no human team could process the output.
The result: 57,000 cells, 150 million synapses, 230 millimeters of blood vessels, compressed into 1.4 petabytes of raw data. For context, 1.4 petabytes is roughly 1.4 million gigabytes. From a speck smaller than a grain of rice.
Now scale that. The full human brain is one million times larger. Mapping the whole thing at this resolution would produce approximately 1.4 zettabytes of data. That’s roughly equal to all the data generated on Earth in a single year. The storage alone would cost an estimated $50 billion and require a 140-acre data center, which would make it the largest on the planet.
And they found things textbooks don’t contain. One neuron had over 5,000 connection points. Some axons had coiled themselves into tight whorls for completely unknown reasons. Pairs of cell clusters grew in mirror images of each other. Jeff Lichtman, the Harvard lead, said there’s “a chasm between what we already know and what we need to know.”
This is why the next step isn’t a human brain. It’s a mouse hippocampus, 10 cubic millimeters, over the next five years. Because even a mouse brain is 1,000x larger than what they just mapped, and the full mouse connectome is the proof of concept before anyone attempts the human one.
We’re building AI systems that loosely mimic neural networks while still unable to fully read the wiring diagram of a single cubic millimeter of the thing we’re trying to imitate. The original is 1.4 petabytes per millionth of its volume. Every AI model on Earth fits in a fraction of that.
The brain runs on 20 watts and fits in your skull. The data center required to merely describe one-millionth of it would span 140 acres.
All day Astronomy@forallcurious
🚨: Scientists mapped 1 mm³ of a human brain ─ less than a grain of rice ─ and a microscopic cosmos appeared.
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US Army Manual, Job description for a platoon leader: “You are responsible for everything your platoon does or fails to do.” @Eagles Sirianni defends A.J. Brown after in-game spat - via @ESPN App espn.com/video/clip?id=…
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Joseph DeSimone retweetledi
Here are my predictions for 2050 (the world we can create) two years ago at TED and at our CEO conference:
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Joseph DeSimone retweetledi
Still a favorite of mine!
Vinod Khosla@vkhosla
One of our most requested resources within our venture assistance is help with pitching and storytelling -- here's the workshop on "Nailing your Fundraise" i gave our CEOs at our summit and full deck linked on our site khoslaventures.com/nail-your-rais…
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“Agency” will be the overarching theme for my @Stanford ENG189/289 class this spring entitled: “Career Building: Entrepreneurship / Intrapreneurship, People, Innovation, Decision-Making and Impact” @StanfordEng @StanfordMed @DeSimoneLab
Andrej Karpathy@karpathy
Agency > Intelligence I had this intuitively wrong for decades, I think due to a pervasive cultural veneration of intelligence, various entertainment/media, obsession with IQ etc. Agency is significantly more powerful and significantly more scarce. Are you hiring for agency? Are we educating for agency? Are you acting as if you had 10X agency? Grok explanation is ~close: “Agency, as a personality trait, refers to an individual's capacity to take initiative, make decisions, and exert control over their actions and environment. It’s about being proactive rather than reactive—someone with high agency doesn’t just let life happen to them; they shape it. Think of it as a blend of self-efficacy, determination, and a sense of ownership over one’s path. People with strong agency tend to set goals and pursue them with confidence, even in the face of obstacles. They’re the type to say, “I’ll figure it out,” and then actually do it. On the flip side, someone low in agency might feel more like a passenger in their own life, waiting for external forces—like luck, other people, or circumstances—to dictate what happens next. It’s not quite the same as assertiveness or ambition, though it can overlap. Agency is quieter, more internal—it’s the belief that you *can* act, paired with the will to follow through. Psychologists often tie it to concepts like locus of control: high-agency folks lean toward an internal locus, feeling they steer their fate, while low-agency folks might lean external, seeing life as something that happens *to* them.”
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Merry Christmas and Happy Holidays—made for granddaughters!
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Great bike ride today at Butano State Park in the Santa Cruz Mountains! Up 3000 feet for 21 miles and perfect weather. Always inspiring to see all of the @iamspecialized saddles and to hear all the great feedback from world class mountain bikers before we embarked… bravo @Carbon !!
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Love the holidays with these little ones! Happy Thanksgiving!
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We have a Super Bowl championship defense. A Super Bowl championship front line. Really great skill players in QB, running back and receivers that if they can click…go birds! @Eagles Love getting back to Philly!
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Great visit to the @CUSystem to deliver the Distinguished Patten Lecture in Chemical Engineering! Great to see old friends and meet many new people! A big thank you to Kristi Anseth (@kanseth) and Chris Bowman (@BowmanChri) for being wonderful hosts!! A mecca for light based science and engineering and advanced materials ! As well as high temperature processing!! Very impressive and strong innovation!!
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Joseph DeSimone retweetledi
Big news💥: We @Carbon are announcing a $60M fundraise to scale capacity and secure our position as the leader in additive manufacturing.
The funding round was headlined by @sequoia, @silverlake_news, @adidas, @BaillieGifford, Madrone Capital, Northgate Capital and others.
Carbon is powering applications in consumer products, healthcare, and auto/industrial/defense. This round will allow us to scale and go faster to get the necessary tools in the hands of creators and makers to build high performance products where and when they need.
Congrats to the team! Onward!
carbon3d.com/news/press-rel…
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Joseph DeSimone retweetledi
Joseph DeSimone retweetledi
What an inspiring day! 🌟
@Joseph_DeSimone (Ph.D. ’90) returned home to @VTScience to share insights on innovation, collaboration & impact as our J. Mark Sowers Distinguished Lecturer. Huge thanks to Debi & Mark Sowers for making this series possible! #ThisIsHome @KevinTPitts
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Great Homecoming event today at @UrsinusCollege! So proud of the entire Ursinus community for coming out to support our students today, especially at the football game and our exciting outdoor kickoff event for the mens and womens wrestling teams! Student athletes epitomize grit, preparation, discipline and tenacity—all of the attributes needed as they emerge from Ursinus to face the world head on! Go Bears!
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