karen (appleton) page

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karen (appleton) page

karen (appleton) page

@karenappleton

GP at B Capital. Exec @ Box, Apple, Prosper.

Snowmass Village Katılım Mayıs 2008
2.9K Takip Edilen1.9K Takipçiler
Mamoon Hamid
Mamoon Hamid@mamoonha·
Today @kleinerperkins announces KP22, our twenty-second venture fund with $1 billion to back early stage companies, alongside $2.5 billion in growth funds to back high-inflection, category-defining businesses. Together, these new funds total $3.5 billion and reflect our conviction that this is one of the most important company-building periods in our firm's 54-year history. We are at a breakthrough moment. The best founders are putting down roots right now, and building enduring companies. kleinerperkins.com
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Gandalv
Gandalv@Microinteracti1·
Robert Mueller died last night. He was 81 years old. He had a wife who loved him for sixty years. He had two daughters, one of whom he met for the first time in Hawaii, in 1969, on a few hours of military leave, before he got back on the plane and returned to Vietnam. He had grandchildren. He had a faith he practiced quietly, without performance. He had, in the way of men who have seen real things and survived them, a quality that is increasingly rare and increasingly mocked in the country he spent his life serving. He had integrity. And tonight the President of the United States said good! I have been sitting with that word for hours now. Good. One syllable. The thing you say when the coffee is hot or the traffic is moving. The thing a man who has never had to bury anyone, never had to sit in the specific silence of a room where someone is newly absent, reaches for when he wants the world to know he is satisfied. Good. The daughters are crying and the wife is alone in the house and good. I want to speak directly to the Americans reading this. Not the political Americans. Just the human ones. The ones who have lost a father. The ones who know what it is to be in that first hour, when you keep forgetting and then remembering again, when ordinary objects become unbearable, when the world outside the window seems obscene in its indifference. I want to ask you, simply, to hold that feeling for a moment, and then to understand that the man you elected looked at it and typed a single word. Good. This is not a country having a bad day. I need you to understand that. Countries have bad days. Elections go wrong. Leaders disappoint. Institutions bend. But there is a different thing, a rarer and more terrible thing, that happens when the moral center of a place simply gives way. Not dramatically. Not with a single catastrophic event. But quietly, in increments, until one evening a president celebrates the death of an old man whose family is still warm with grief, and enough people find it acceptable that it becomes the weather. Just the weather. That is what is happening. That is what has happened. The world knows. From Tokyo to Oslo, from London to Buenos Aires, people are not angry at America tonight. Anger would mean there was still something to fight for, some remaining faith to be betrayed. What I see, in the reactions from everywhere that is not here, is something older and sadder than anger. It is the look people get when they have waited a long time for someone they love to find their way back, and have finally understood that they are not coming. America is being grieved. Past tense, almost. The idea of it. The thing it represented to people who had nothing else to believe in, who came here with everything they owned in a single bag because they had heard, somehow, across an ocean, that this was the place where decency was written into the walls. That idea is not resting. It is not suspended. It is being buried, in real time, with 7,450 likes before dinner. And the church said nothing. Seventy million people have decided that this man, this specific man who has cheated everyone he has ever made a promise to, who has mocked the disabled and the dead and the grieving, who celebrated tonight while a family wept, is an instrument of God. The pastors who made that bargain did not just trade away their credibility. They traded away the thing that made them worth listening to in the first place. The cross they carry now is a costume. The faith they preach is a loyalty oath with scripture attached. When the history of American Christianity is written, this will be the chapter they skip at seminary. Now I want to talk about the men who stand next to him. Because this is the part that actually breaks my heart. JD Vance is not a bad man. I have to say that, because it is true, and because the truth matters even now, especially now. Marco Rubio is not a bad man. Lindsey Graham is not a bad man. They are idiots, but not bad, as in BAD! These are men with mothers who raised them and children who love them and friends who remember who they were before all of this. They are not monsters. Monsters are simple. Monsters do not cost you anything emotionally because there is nothing in them to mourn. These men are something more painful than monsters. They are men who knew better, and know better still, and will get up tomorrow and do it again. Every small compromise they made had a reason. Every moment they looked the other way had a justification that sounded, at the time, almost reasonable. And now they have arrived here, at a place where a president celebrates the death of an old man and they will find a way, on television, to say nothing that means anything, and they will go home to houses where children who carry their name are waiting, and they will say goodnight, and they will say nothing. Their oldest friends are watching. The ones who knew Rubio when he still believed in something. Who knew Graham when he said, out loud, on the record, that this exact man would destroy the Republican Party and deserve it. Who sat next to Vance and thought here is someone worth knowing. Those friends are not angry tonight. They moved through anger a long time ago. What they feel now is the quiet, irrecoverable sadness of watching someone disappear while still being present. Of watching a person they loved choose, again and again, to become less. That is what cowardice costs. Not the coward. The people who loved him. And in the comments tonight, the followers celebrate. People who ten years ago brought casseroles to grieving neighbours. Who stood in the rain at gravesides and meant the words they said. Who told their children that we do not speak ill of the dead because the dead were someone's beloved. Those people are tonight typing gleeful things about a man whose daughters are not yet done crying. And they feel clean doing it. Righteous. Because somewhere along the way the thing they were given in exchange for their decency was the feeling of belonging to something, and that feeling is very hard to give up even when you can no longer remember what you gave for it. When Trump is gone, they will still be here. Standing in the silence where the noise used to be. Without the permission the crowd gave them. Without the pastor who told them their cruelty was holy. They will be alone with what they said and what they cheered and what they chose to become, and there will be no one left to tell them it was righteous. That morning is coming. Robert Mueller flew across the Pacific on military leave to hold his newborn daughter for a few hours before returning to the war. He came home. He buried his dead with honour. He served presidents of both parties because he understood that the institution was larger than any one man. He told his grandchildren that a lie is the worst thing a person can do, that a reputation once lost cannot be recovered, and he lived that, every day, in the quiet and unglamorous way of people who actually believe what they say. He was the kind of American the world used to point to when it needed to believe the story was true. He died last night. His wife is alone in their house in Georgetown. His daughters are learning what the world is without him in it. And somewhere in the particular hush that falls over a family in the first hours of loss, the most powerful man and the biggest loser on earth sent a message to say he was glad. The world that loved what America was supposed to be is grieving tonight. Not for Robert Mueller only. For the country that produced him and then became this. For the distance between what was promised and what was delivered. For the suspicion, growing quieter and more certain with each passing month, that the America people believed in was always partly a story, and the story is over now, and there is nothing yet to replace it. That is all it needed to be. A man died. His family is broken open with grief. That is all it needed to be. Instead the President said good. And the country that once stood for something looked away 🇺🇸 Gandalv / @Microinteracti1
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karen (appleton) page
karen (appleton) page@karenappleton·
The issue of prominent leaders in the files points to a deeper accountability gap in how we think about corporate leadership and in many cases, governance. When a CEO’s personal antics erodes the company’s integrity and create reputational risk for the entity, you’re no longer managing optics—you’re dealing with a governance failure. Leaders are stewards of trust, and when those leaders aren't held accountable, but instead stay in place under a cloud of low integrity behavior, they’re effectively transferring reputational and legal risk onto the entire organization.
NBC News@NBCNews

Emails and other documents show that Epstein was in contact with at least 20 prominent tech executives, investors and researchers, including some current CEOs, according to an NBC News review of a portion of the documents. nbcnews.com/tech/tech-news…

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Harry Stebbings
Harry Stebbings@HarryStebbings·
Chance I will be in Georgia, US, next week for a very cool project. If so, who are the coolest and best people to interview in Georgia?
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Brian Halligan
Brian Halligan@bhalligan·
I’m starting to worry about Massachusetts 1. Biotech is way off from a few years ago 2. Only 1 of the top 50 ai companies are in MA 3. The Fed research funding cuts hitting MIT, Harvard, Whoi are brutal. 4. The millionaires tax is working in the short run, but I know a lot of wealthy folks preparing for a FL move. 5. A glut of empty condos 6. It’s not “cool” for young folks 7. It’s expensive as sh-t. I honestly don’t think the MA/Boston govt can do that much about it as they are kind of macro issues. I give them big credit for working on building more housing and fixing the T, which will help. I’m trying to help w HubSpot, partnering w WHOI, teaching at MIT. I’d like to help more. Specifically I’d like to encourage and help more ai and climate companies in the state. I think ai and climate should be our dual growth engines.
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Bill Clerico
Bill Clerico@billclerico·
@bhalligan I invest in climate and am in Boston June and July - if I can help I would love to. Started my company in Boston in 2008 (where I met @dharmesh !) and then moved to CA when we got into YC
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karen (appleton) page
karen (appleton) page@karenappleton·
Bonkers.
Peter Girnus 🦅@gothburz

Last quarter I rolled out Microsoft Copilot to 4,000 employees. $30 per seat per month. $1.4 million annually. I called it "digital transformation." The board loved that phrase. They approved it in eleven minutes. No one asked what it would actually do. Including me. I told everyone it would "10x productivity." That's not a real number. But it sounds like one. HR asked how we'd measure the 10x. I said we'd "leverage analytics dashboards." They stopped asking. Three months later I checked the usage reports. 47 people had opened it. 12 had used it more than once. One of them was me. I used it to summarize an email I could have read in 30 seconds. It took 45 seconds. Plus the time it took to fix the hallucinations. But I called it a "pilot success." Success means the pilot didn't visibly fail. The CFO asked about ROI. I showed him a graph. The graph went up and to the right. It measured "AI enablement." I made that metric up. He nodded approvingly. We're "AI-enabled" now. I don't know what that means. But it's in our investor deck. A senior developer asked why we didn't use Claude or ChatGPT. I said we needed "enterprise-grade security." He asked what that meant. I said "compliance." He asked which compliance. I said "all of them." He looked skeptical. I scheduled him for a "career development conversation." He stopped asking questions. Microsoft sent a case study team. They wanted to feature us as a success story. I told them we "saved 40,000 hours." I calculated that number by multiplying employees by a number I made up. They didn't verify it. They never do. Now we're on Microsoft's website. "Global enterprise achieves 40,000 hours of productivity gains with Copilot." The CEO shared it on LinkedIn. He got 3,000 likes. He's never used Copilot. None of the executives have. We have an exemption. "Strategic focus requires minimal digital distraction." I wrote that policy. The licenses renew next month. I'm requesting an expansion. 5,000 more seats. We haven't used the first 4,000. But this time we'll "drive adoption." Adoption means mandatory training. Training means a 45-minute webinar no one watches. But completion will be tracked. Completion is a metric. Metrics go in dashboards. Dashboards go in board presentations. Board presentations get me promoted. I'll be SVP by Q3. I still don't know what Copilot does. But I know what it's for. It's for showing we're "investing in AI." Investment means spending. Spending means commitment. Commitment means we're serious about the future. The future is whatever I say it is. As long as the graph goes up and to the right.

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karen (appleton) page
karen (appleton) page@karenappleton·
“With the exception of antibiotics and vaccines, there may be no medication in the modern world that can improve the health outcomes of older women on a population level more than hormone therapy,” FDA officials apple.news/A0o9joBRiSJGz8…
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karen (appleton) page@karenappleton·
@Hadley That is literally how I described a moat during a panel discussion this week 🤩
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Hadley Harris
Hadley Harris@Hadley·
We’re in a weird era for startups where perception has become the moat. Raise early, get labeled a “category leader,” and that perception attracts capital, customers, and talent until it’s no longer perception. The irony is many kings were crowned long before they’d earned it.
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Ashley Mayer
Ashley Mayer@ashleymayer·
Accidentally texted "I'll be in the arena" instead of "I'll be in the area" and I think I'll go die now.
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villi
villi@villi·
The Blitzhire Acquistion. In this blog post I try to explain the drivers behind these new strange acquisitions in AI, how these deals are structured and why, where the money goes and how, and what happens to the remaining employees. Feedback is welcome. @villispeaks/the-blitzhire-acquisition-e39361ed00bb" target="_blank" rel="nofollow noopener">medium.com/@villispeaks/t…
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Justine Moore
Justine Moore@venturetwins·
You can just make t-shirts for your dog friend’s 10th birthday and send them to all her fans. Happy birthday to Kai - the legend! 🎉
Justine Moore tweet mediaJustine Moore tweet media
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Nichole Wischoff
Nichole Wischoff@NWischoff·
Kicking off our Wischoff Ventures at a Steakhouse Dinner Series in LA this week. One per quarter. Founders and fellow GPs welcome. Pretty simple - must eat steak and enjoy good wine. LMK if you would like to join. NYC up next.
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karen (appleton) page
karen (appleton) page@karenappleton·
Congrats to the @OssiumHealth team!
Josh Kopelman@joshk

2,850 days. Almost 8 years. That's how long it took to save a life. In August of 2016 my @firstround partner, @btrenchard, led @OssiumHealth's Seed round. And in May of 2024, a 68 year-old woman in Michigan became the first patient to receive a bone marrow transplant from a deceased donor. When she was not able to find a bone marrow match from a living donor, she enrolled in Ossium's PRESERVE I clinical trial -- and matched with bone marrow stored in at Ossium's biobank (the only bone marrow biobank in the world). Until now, every time an organ donor died, their bone marrow was discarded. Thrown away. Regardless of whether there was a cancer patient who was a genetic match and desperately needed that bone marrow. Ossium figured out how to collect, process and cryopreserve bone marrow from deceased organ donors. Their network of 27 organ procurement organizations recovers bone marrow from organ donors and transports it to Ossium's facility where the company processes and manufactures the doses for the patients -- and cryopreserves it in their biobank. Before Ossium it typically took months to find a living bone marrow donor who is: a) a genetic match, b) healthy enough, and c) willing to donate. And those are months that a blood cancer patient often doesn't have. Today there is a woman in Michigan who is alive -- and on a great recovery trajectory from her blood cancer, because Ossium had a bone marrow unit that could match her and save her life. Congrats to Kevin Caldwell and the entire Ossium team. We can't wait to see the impact you have over the next 2,850 days. More info here: foxnews.com/health/leukemi…

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