karen (appleton) page

1.6K posts

karen (appleton) page

karen (appleton) page

@karenappleton

GP at B Capital. Exec @ Box, Apple, Prosper.

Snowmass Village Katılım Mayıs 2008
2.9K Takip Edilen1.9K Takipçiler
karen (appleton) page
karen (appleton) page@karenappleton·
The issue of prominent leaders in the files points to a deeper accountability gap in how we think about corporate leadership and in many cases, governance. When a CEO’s personal antics erodes the company’s integrity and create reputational risk for the entity, you’re no longer managing optics—you’re dealing with a governance failure. Leaders are stewards of trust, and when those leaders aren't held accountable, but instead stay in place under a cloud of low integrity behavior, they’re effectively transferring reputational and legal risk onto the entire organization.
NBC News@NBCNews

Emails and other documents show that Epstein was in contact with at least 20 prominent tech executives, investors and researchers, including some current CEOs, according to an NBC News review of a portion of the documents. nbcnews.com/tech/tech-news…

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Harry Stebbings
Harry Stebbings@HarryStebbings·
Chance I will be in Georgia, US, next week for a very cool project. If so, who are the coolest and best people to interview in Georgia?
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Brian Halligan
Brian Halligan@bhalligan·
I’m starting to worry about Massachusetts 1. Biotech is way off from a few years ago 2. Only 1 of the top 50 ai companies are in MA 3. The Fed research funding cuts hitting MIT, Harvard, Whoi are brutal. 4. The millionaires tax is working in the short run, but I know a lot of wealthy folks preparing for a FL move. 5. A glut of empty condos 6. It’s not “cool” for young folks 7. It’s expensive as sh-t. I honestly don’t think the MA/Boston govt can do that much about it as they are kind of macro issues. I give them big credit for working on building more housing and fixing the T, which will help. I’m trying to help w HubSpot, partnering w WHOI, teaching at MIT. I’d like to help more. Specifically I’d like to encourage and help more ai and climate companies in the state. I think ai and climate should be our dual growth engines.
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Bill Clerico
Bill Clerico@billclerico·
@bhalligan I invest in climate and am in Boston June and July - if I can help I would love to. Started my company in Boston in 2008 (where I met @dharmesh !) and then moved to CA when we got into YC
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karen (appleton) page
karen (appleton) page@karenappleton·
Bonkers.
Peter Girnus 🦅@gothburz

Last quarter I rolled out Microsoft Copilot to 4,000 employees. $30 per seat per month. $1.4 million annually. I called it "digital transformation." The board loved that phrase. They approved it in eleven minutes. No one asked what it would actually do. Including me. I told everyone it would "10x productivity." That's not a real number. But it sounds like one. HR asked how we'd measure the 10x. I said we'd "leverage analytics dashboards." They stopped asking. Three months later I checked the usage reports. 47 people had opened it. 12 had used it more than once. One of them was me. I used it to summarize an email I could have read in 30 seconds. It took 45 seconds. Plus the time it took to fix the hallucinations. But I called it a "pilot success." Success means the pilot didn't visibly fail. The CFO asked about ROI. I showed him a graph. The graph went up and to the right. It measured "AI enablement." I made that metric up. He nodded approvingly. We're "AI-enabled" now. I don't know what that means. But it's in our investor deck. A senior developer asked why we didn't use Claude or ChatGPT. I said we needed "enterprise-grade security." He asked what that meant. I said "compliance." He asked which compliance. I said "all of them." He looked skeptical. I scheduled him for a "career development conversation." He stopped asking questions. Microsoft sent a case study team. They wanted to feature us as a success story. I told them we "saved 40,000 hours." I calculated that number by multiplying employees by a number I made up. They didn't verify it. They never do. Now we're on Microsoft's website. "Global enterprise achieves 40,000 hours of productivity gains with Copilot." The CEO shared it on LinkedIn. He got 3,000 likes. He's never used Copilot. None of the executives have. We have an exemption. "Strategic focus requires minimal digital distraction." I wrote that policy. The licenses renew next month. I'm requesting an expansion. 5,000 more seats. We haven't used the first 4,000. But this time we'll "drive adoption." Adoption means mandatory training. Training means a 45-minute webinar no one watches. But completion will be tracked. Completion is a metric. Metrics go in dashboards. Dashboards go in board presentations. Board presentations get me promoted. I'll be SVP by Q3. I still don't know what Copilot does. But I know what it's for. It's for showing we're "investing in AI." Investment means spending. Spending means commitment. Commitment means we're serious about the future. The future is whatever I say it is. As long as the graph goes up and to the right.

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karen (appleton) page
karen (appleton) page@karenappleton·
“With the exception of antibiotics and vaccines, there may be no medication in the modern world that can improve the health outcomes of older women on a population level more than hormone therapy,” FDA officials apple.news/A0o9joBRiSJGz8…
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karen (appleton) page
karen (appleton) page@karenappleton·
@Hadley That is literally how I described a moat during a panel discussion this week 🤩
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Hadley Harris
Hadley Harris@Hadley·
We’re in a weird era for startups where perception has become the moat. Raise early, get labeled a “category leader,” and that perception attracts capital, customers, and talent until it’s no longer perception. The irony is many kings were crowned long before they’d earned it.
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Ashley Mayer
Ashley Mayer@ashleymayer·
Accidentally texted "I'll be in the arena" instead of "I'll be in the area" and I think I'll go die now.
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karen (appleton) page retweetledi
villi
villi@villi·
The Blitzhire Acquistion. In this blog post I try to explain the drivers behind these new strange acquisitions in AI, how these deals are structured and why, where the money goes and how, and what happens to the remaining employees. Feedback is welcome. @villispeaks/the-blitzhire-acquisition-e39361ed00bb" target="_blank" rel="nofollow noopener">medium.com/@villispeaks/t…
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Justine Moore
Justine Moore@venturetwins·
You can just make t-shirts for your dog friend’s 10th birthday and send them to all her fans. Happy birthday to Kai - the legend! 🎉
Justine Moore tweet mediaJustine Moore tweet media
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Nichole Wischoff
Nichole Wischoff@NWischoff·
Kicking off our Wischoff Ventures at a Steakhouse Dinner Series in LA this week. One per quarter. Founders and fellow GPs welcome. Pretty simple - must eat steak and enjoy good wine. LMK if you would like to join. NYC up next.
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karen (appleton) page
karen (appleton) page@karenappleton·
Congrats to the @OssiumHealth team!
Josh Kopelman@joshk

2,850 days. Almost 8 years. That's how long it took to save a life. In August of 2016 my @firstround partner, @btrenchard, led @OssiumHealth's Seed round. And in May of 2024, a 68 year-old woman in Michigan became the first patient to receive a bone marrow transplant from a deceased donor. When she was not able to find a bone marrow match from a living donor, she enrolled in Ossium's PRESERVE I clinical trial -- and matched with bone marrow stored in at Ossium's biobank (the only bone marrow biobank in the world). Until now, every time an organ donor died, their bone marrow was discarded. Thrown away. Regardless of whether there was a cancer patient who was a genetic match and desperately needed that bone marrow. Ossium figured out how to collect, process and cryopreserve bone marrow from deceased organ donors. Their network of 27 organ procurement organizations recovers bone marrow from organ donors and transports it to Ossium's facility where the company processes and manufactures the doses for the patients -- and cryopreserves it in their biobank. Before Ossium it typically took months to find a living bone marrow donor who is: a) a genetic match, b) healthy enough, and c) willing to donate. And those are months that a blood cancer patient often doesn't have. Today there is a woman in Michigan who is alive -- and on a great recovery trajectory from her blood cancer, because Ossium had a bone marrow unit that could match her and save her life. Congrats to Kevin Caldwell and the entire Ossium team. We can't wait to see the impact you have over the next 2,850 days. More info here: foxnews.com/health/leukemi…

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nico
nico@nicochristie·
early hires are the unsung heroes. not founders, not vcs, not professional managers.
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Olivia Moore
Olivia Moore@omooretweets·
2️⃣ Better photo and video search You can now execute complex searches of content IN photos or videos in natural language - ex. “Mike wearing a suit” or “Kai running down a hill” This is surprisingly useful, and the ability to prompt “Memories” videos is also fun.
Olivia Moore tweet mediaOlivia Moore tweet media
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Olivia Moore
Olivia Moore@omooretweets·
I’ve been testing Apple’s new AI features for the last few weeks as part of the iOS 18 developer beta. Some of them are AMAZING, and some need…a little more tuning. What’s most noteworthy 👇
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karen (appleton) page
karen (appleton) page@karenappleton·
It may not be a straight climb, but we’ve got to keep climbing. Takes a girlboss village.
Sophia Amoruso 3.0@sophiaamoruso

It happened to me first — headlines portraying me as a “toxic leader” when I had to make the same, often unpopular, decisions that my male peers did without critique. For them, it’s called Founder Mode, and it’s celebrated (a proper noun! With its own merch! And trademarks being filed as I write this!). For women, it’s called “toxic”. After my “fall” in 2016, I watched an incredible cohort of female founders come up behind me. I thought there was something fundamentally wrong with me and that they had it all figured out. They were my friends, but it was hard to watch them win. I secretly muted their Instagram accounts. Why was I the only piece of shit female founder? What did they possess that I didn’t? Was it my upbringing? Maybe the media was right. These women took big swings, raised huge rounds, and were held up as examples for countless other women who for the first time saw that their aspirations might actually be within reach. And then, one by one, they were canceled. Our responsibility wasn’t just to pave the way for women, but to do it perfectly — and when we weren’t examples of whatever warped mutation the word Girlboss (which is now immortalized in the Merriam-Webster dictionary) had come to symbolize, we were “toxic.” No one expects men to build a utopian workplace that cures institutional biases, but we were expected to do just that. This is all too complex for an X post, and I’m not making excuses for anyone. Today, posts like this are out of character for me because, like them (as the non self-appointed consigliere for scorned Girlbosses, I know), we’ve all been told to keep gender out of the conversation. The media’s glee surrounding the “fall of the Girlboss” has committed, at scale, more harm than any pretty, young, white (let’s call it what it is), often unrelateable female founder could ever do. The phenomenon reminded a generation of women what we’d been told for eons: be nice and stay in your lane, or else.

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