Klann Lab

Check out @prerana123's exciting paper on sex-specific differences in anxiety-like behaviors in TSC. Amazing amount of work using multiple approaches. Many thanks to all of our collaborators!

So happy for @Mauricio_Neuro, whose paper was published over the weekend. He shows how eIF2alpha becomes dephosphorylated in response to neuronal stimulation, answering a long-standing question in the field. cell.com/cell-reports/f…. Congratulations Mauricio!

@DrSharma_V @SonenbergLab @AKhoutorsky @Neurosenblum @Masha_P_ @wesparkhealth Congratulations on the lovely work Vijen!

I'm excited to share our latest research in PNAS. Our collective team effort has discovered that translation regulation in astrocytes helps consolidate long-term memories. Thanks @SonenbergLab @AKhoutorsky @KlannLab @Neurosenblum @Masha_P_ @wesparkhealth pnas.org/doi/10.1073/pn…

Big week for @Muhaned711 and the lab. On Monday, his first, first author paper was published in PNAS. Today, he gave an outstanding presentation and successfully defended his Ph.D. thesis. Muhaned rocks - we are all proud to have had the opportunity to do neuroscience with him!

Excited to share @Muhaned711's now published work describing the impact of epilepsy- and ASD-associated mutations in EEF1A2 on de novo translation, elongation, tRNA-binding, and actin bundling. Congratulations Muhaned! pnas.org/doi/10.1073/pn…

@superkash @denisejcai @DrJessicaAlapin Thanks Tom!

Delighted to share @DrJessicaAlapin's exciting work on an optogenetic tool that can be used to block eIF4E-dependent translation in specific cell types in the brain. Many thanks to all former/current lab members for their help in pushing this through! doi.org/10.1101/2023.0…

@RuggeroDavide @DrJessicaAlapin Thanks Davide!

@KlannLab @DrJessicaAlapin Great work all! Congrats!

@angalus_d @DrJessicaAlapin Thanks Sulagna!

@KlannLab @DrJessicaAlapin Glad to see this! Congratulations!

Thrilled to share @fran_longo17's latest work describing cell type-specific disruption of striatal circuitry in FXS. Many thanks to our collaborators in the labs of @CarterAG, @BagniLab, & @NicTritsch - sometimes it takes a village! sciencedirect.com/science/articl…

@Neurosenblum @Mauricio_Neuro Thanks Kobi!

@KlannLab @Mauricio_Neuro Congratulation Mauricio, Eric et al., very important answer for an old pivotal question

Really excited to share @Mauricio_Neuro's latest work, where he describes a novel mechanism for eIF2alpha dephosphorylation in response to plasticity-inducing stimulation, answering a long-standing question in the field of neuronal translation. Congrats! biorxiv.org/content/10.110…

Two open postdoc positions at @BagniLab @DNF_neuro! We are seeking for motivated candidates to investigate the mechanisms underlying neurodevelopmental deficits using🪰and 🐭. #postdoc #neuroscience #DNF Send CV, Cover letter and 3 referees by August 1st, 2023 (see ad).

Excited to share @Muhaned711's work, where he describes how three separate ASD- and epilepsy-associated mutations in the gene encoding eEF1A2 alter translation elongation, neuronal morphology, tRNA binding, and actin bundling. biorxiv.org/content/10.110…

Happy to share @fran_longo17's work describing how cell type-specific changes in striatal MSNs drive repetitive behaviors in FXS mice. Many thanks to @CarterAG, @NicTritsch, & @BagniClaudia labs for sharing their expertise! biorxiv.org/content/10.110…

Check out our paper on the optical control of translation with a puromycin switch - in neurons! A collaboration with @tongil_ko @KlannLab @mo_hannes pubs.acs.org/doi/10.1021/ja… #ribosome #photopharmacology #translation #puromycin

Thrilled to share our review on the modulation of emotional and social behaviors by oxytocin signaling in limbic network!! It was great fun working on this together with @RodrigoTrianaD2, Sayali Ranade, Jahel Guardado, @LeDouxScience and @klannlab. frontiersin.org/articles/10.33…

Stephen T. Warren Memorial Symposium Nov 29-30, 2022 @EmoryMedicine -- honoring giant in #fragilex + repeat disorders field! More speakers announced including @nelsondl @EricTWang @KlannLab @SusanLAckerman1 Registration link: surveymonkey.com/r/N7F65YR

Today at @NYU_CNS, @erin_schuman gave the Valle Foundation Visiting Professor Lecture, where she discussed her groundbreaking work on local neuronal translation. Erin's talk was amazing - we are very excited to host her for an entire month here in NYC!

The EMBO Workshop on RNA Localization and Local Translation held in Sant Feliu De Guixols, Spain concluded today. What a great meeting! Many thanks to ⁦⁦@BassellLab⁩, ⁦@ChaoLabFMI⁩, Anne Ephrussi, and Geraldine Seydoux for organizing!