Lukas Schmidheini

Our paper describing an RNA-LNP prime editing strategy for treating phenylketonuria was published today in @natBME (1/7) nature.com/articles/s4155… @schwanklab @UZH_Science @UZH_en @KispiZuerich @ETH_en

If you're more of a visual learner, this explainer video is for you 🙌

TnpB is much smaller than the well-known CRISPR-Cas "gene scissors". The tool for targeted modification of the genome has now been improved to such an extent that it could one day be used to treat a genetic defect that leads to a lifelong high cholesterol level. news.uzh.ch/en/articles/me… @schwanklab @marquark @UZH_IPT

Excited to share our latest study! Today in @naturemethods the @schwanklab and @krauthammerlab report in @marquark et al. 'Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs' (1/6) nature.com/articles/s4159…

Our paper exploring the effect of chromatin on prime editing and diverse pegRNA designs was published today! 👨‍💻🧬🎉 rdcu.be/dLu0f pridict.it @UZH_Science @NatureBiotech @schwanklab @krauthammerlab @bvansteensellab 🧵

Impossible to do the field justice on a few pages but we (@jgooten @omarabudayyeh @jsw @JuliaJoung @LukeKoblan) tried our best to give an overview of current CRISPR technologies in @NatRevMCB rdcu.be/dxDD9

🚨New preprint🚨Today, we're excited to share our latest study, "Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning" via @biorxivpreprint! @schwanklab @krauthammerlab @bvansteensellab @UZH_Science biorxiv.org/content/10.110… 🧵

@schwanklab @nicopmat @marquark @tanjarothgangl @KisslingLucas @BoeckDesiree @priswang5 @ChrisChanez89 @MartinJinek @Addgene And here is the ReadCube link to access the paper🔓: rdcu.be/dmIkc

I’m very thankful for all the support from our @schwanklab members, including @nicopmat, @marquark, @tanjarothgangl, @KisslingLucas, @BoeckDesiree, @priswang5 and @ChrisChanez89 from the lab of @MartinJinek. Plasmids related to this study are available on @Addgene. (6/6)

Today we @schwanklab report in @nchembio a PACE-evolved, PAM-relaxed, compact Cas9 enzyme. evoCjCas9 supports base- and prime editing, and, owing to its small size, can be delivered on single AAV vector systems. nature.com/articles/s4158… @UZH_Science @ETH_en (1/6)

🎙️Excited to launch my new podcast #CRISPRli, a deep dive into the revolutionary world of #CRISPR. I'll be hosting interviews with top genome editing experts. Ideal for scientists, students or anyone curious about this cutting-edge tech. #GeneEditing open.spotify.com/show/1NDD79fy2…

Excited to see our study "Predicting prime editing efficiency and product purity by deep learning" published in @NatureBiotech today! @schwanklab @krauthammerlab nature.com/articles/s4158… 1/14

New preprint of @schwanklab on bioRxiv. Congrats @PatrikSimmler and collaborators for this nice story!

New preprint from the @schwanklab! We present a novel base editor variant (HNHx-ABE) with a shifted editing window and reduced size. Congratulations to @lukas_villiger and everyone involved in this elegant study!💪 biorxiv.org/content/10.110…

My lab is hosting a happy hour together with Zenobi-Wong and Schwank labs. The theme is airports. What you see here is a homebrew, working metal detector with alarm that attendees pass through upon exiting the elevator. Welcome to @ETH_en, where even the biologists are techies.