@jer_06200 @ChicheJohanna Congratulations to the whole Team 🎉🎉
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Alex Puissant Lab
528 posts
Alex Puissant Lab
@LabPuissant
Alex Puissant, Ph.D., is a Principal Investigator in the Hematology-Oncology Department at the Saint Louis Research Institute & Hospital, Paris, France.
Paris, France Katılım Ocak 2019
546 Takip Edilen544 Takipçiler
Building on our Cell Met 2019 study, we show why some DLBCL patients relapse after L-asparaginase: metabolic rewiring drives DNA damage and PARP1/2 dependence. Targeting this with olaparib exploits resistance and enhances killing.
Kudos to @ChicheJohanna
nature.com/articles/s4146…
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@FagnanAlexandre @Nature Congrats Alex on this outstanding study!
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🔥I am so thrilled to share our latest study published in @Nature , describing how we think emergency type-2 myelopoiesis is initiated in hematopoietic progenitor cells.
👇👇
nature.com/articles/s4158…
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Out today in @cellcellpress new work from the lab led by Abby Xie and @jules_stef asks, when and why do cells use the TCA cycle?
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I could not be more excited about this project and working with this incredible team. I’m grateful to the funding agencies for believing in promise of novel early cancer detection strategies for patients with #LFS. @DanaFarberNews @DFBC_PedCare
The Mark Foundation for Cancer Research@TheMarkFdn
Trevor Pugh (@PughLab), Brian Crompton (@bdcrompton), Paul Northcott, and Kara Maxwell (@KMaxwellLab) are developing an accurate, accessible blood test for patients with very high inherited cancer risk due to conditions such as Li-Fraumeni Syndrome. 🧬
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Alex Puissant Lab retweetledi
The new issue of #ScienceTranslationalMedicine is out!
A marker of poor outcomes during invasive candidiasis could inform personalized therapies, a skin temperature study in patients helps answer a longstanding question in narcolepsy research, and more. scim.ag/4qEdJww
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Alex Puissant Lab retweetledi
Methylation, acetylation and cell fate dlvr.it/TQcHxX
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Alex Puissant Lab retweetledi
A screening study that leverages SPOKE knowledge graphing examines over 1500 known drugs, and reveals that the drug candidate #bavisant has remyelinating and neuroprotective properties in models of #MultipleSclerosis. @InstitutCerveau scim.ag/3ZrG8tJ
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Alex Puissant Lab retweetledi
RESEARCH | AE Stewart, DK Zachman, A Puissant, KC Wood, @matthewhirschey et al (@Inserm)
A #MachineLearning based approach probing pathway coessentiality reveals that #ComplexII of the ETC regulates de novo #purine synthesis, and can be targeted for AML
nature.com/articles/s4225…
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Excited to share our new article in @LeukemiaJournal on the prevalence and prognostic impact of myelodysplasia-related features in #VEXAS.
A nationwide effort from the French FRENVEX network 🇫🇷
rdcu.be/eZlvF
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Alex Puissant Lab retweetledi
Nature research paper: Polyamine-dependent metabolic shielding regulates alternative splicing
go.nature.com/459XVZP
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Alex Puissant Lab retweetledi
Monitoring markers of #tau protein in the blood can predict functional outcomes in patients recovering from ischemic #stroke better than MRI, according to a comprehensive study of more than 1200 patients. @ISD_Research scim.ag/49oBrqD
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Join us in welcoming Ross Levine, MD, as Editor-in-Chief of Blood Cancer Discovery, serving alongside founding Editors-in-Chief Riccardo Dalla-Favera, MD, and Kenneth C. Anderson, MD. Find out more. brnw.ch/21wZ1Fl
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Alex Puissant Lab retweetledi
A team applies CT/PET imaging in #tuberculosis lung lesions in marmosets receiving 22 different treatment protocols, and shows imaging can predict known clinical outcomes from shortened and standard regimens. @AldridgeLab @taliagreenstein @TuftsMedSchool scim.ag/49t6twk
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Alex Puissant Lab retweetledi
Gene expression profiling of #dengue infections finds that peripheral blood mononuclear cells #PBMC drawn from symptomatic and symptomatic individuals have distinct immune profiles. @sangerinstitute @MahidolU scim.ag/3KMUsti
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Alex Puissant Lab retweetledi
Can #HIV become resistant to #lenacapavir?
An analysis of clinical isolates identifies mutations that shift the capsid protein’s lenacapavir binding pocket and endow resistance, but shows these mutations often come at a high fitness cost. @GileadSciences scim.ag/4aKsPeU
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@landau_lab Warm congratulations to you and your team!!! And happy new year!
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Happy new year/paper!
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A new tech (scG2P) maps genotype (DNA) to phenotype (RNA) in single cells, bringing together the worldviews of genetic & transcriptional heterogeneity. With scG2P we define how mosaicism drivers increase clonal fitness in the aging esophagus.
link 👇
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@lydfinley Congratulations Lydia and Team on this very compelling study!
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Out today 🙌 new work from the lab in which we show that p53-driven senescence enables phospholipid headgroup recycling to help sustain the increased synthesis of membrane phospholipids of senescent cells #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4155…
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Alex Puissant Lab retweetledi
Alex Puissant Lab retweetledi
Small genetic variants occurring naturally from person to person can abolish binding of #MonoclonalAntibody therapeutics to their target, according to a new study. scim.ag/4aR8Hrs
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Happy & healthy new year 💗
Dan Landau@landau_lab
NEW YEAR/~Merwin With what stillness at last you appear in the valley your first sunlight reaching down to touch the tips of a few high leaves so this is the sound of you our knowledge such as it is and our hopes such as they are invisible before us untouched and still possible
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