Anthony Rullo: chemically modulating proximity

A new series of covalent, monovalent glue degraders can co-opt two E3 ligases, DCAF16 and FBBXO22, in a parallel fashion to degrade SMARCA2/4 with chemically and genetically tunable ligase preference nature.com/articles/s4158…

It‘s time to remove the question mark! A huge congrats to @CraigMCrews, Ray Deshaies and the scientists @ArvinasInc. 1st FDA approval for a #PROTAC on May 1st 2026. A day to remember. Extra drinks at the Proxidrugs GRC in a few weeks!

Fast and Selective Labeling of Serine and Threonine in HFIP for Facile Editing of Peptide Alcohol Side Chains | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Just out @J_A_C_S Confined Acids Catalyze a Broadly Applicable β-Selective O-Glycosylation pubs.acs.org/doi/10.1021/ja…

Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulation | ACS Chemical Biology pubs.acs.org/doi/10.1021/ac…

Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation | Bioconjugate Chemistry pubs.acs.org/doi/10.1021/ac…

Discovery of Covalent Ligands with AlphaFold3 | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Confinement Catalysis Enables Macrocyclization at Up to 0.6 M: Selective Formation of Mono- and Dimeric Glycosidic Macrocycles | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Beyond traditional strain-promoted azide–alkyne cycloadditions by achieving orthogonality and rapid kinetics with fluoroalkyl azides Nature Communications 2026 nature.com/articles/s4200…

Discovery of Ultrapotent Heterodimeric Peptide Ligands Using Library-vs-Library RaPID Selections | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

AI‐Based Prediction of PROTAC‐ and Molecular Glue‐Mediated Ternary Complexes: A Comparative Evaluation of AlphaFold 3 and Boltz‐2 - Riepenhausen - 2026 - Archiv der Pharmazie - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/ar…

A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors go.nature.com/4uC0qiM

@vishal_iiserb @Novartis proximity effects ? ;)

@Novartis La Jolla site that contributes significantly to healthcare. Scripps and UCSD in the proximity creates an excellent basic-translational research ecosystem.

@SebVidalChem @dr_kuato

@LabRullo @dr_kuato

Editor's desk response when authors come from... South America Europe/USA/China

@SebVidalChem @dr_kuato Canada isn't having a terribly easy time either....journal depending .....

@dr_kuato I am currently having more trouble than ever to publish some papers, from France....

Nature holds the keys to PPIs—why don't we use them? Some thoughts on stabilizing hotspots without sequence changes, using the emerging non-symmetric stapling. This could unlock the therapeutic potential of native peptides. Now out as @ChemRxiv preprint. chemrxiv.org/doi/full/10.26…

Farewell to a giant in chemical immunology and induced proximity

@chopralab I'm so sorry to hear this. His contributions to synthetic immunology were an inspiration

Today I lost a dear friend, mentor, and colleague. Dr. Philip Low was a brilliant scientist whose discoveries transformed human health. I’m deeply saddened by Phil’s passing and grateful for his friendship and mentorship. His legacy will endure. purdue.edu/newsroom/2026/…

@jaybradner haha, or maybe some heterobifunctional sugars ?

Happy Birthday, Ty! Good boy. Have some cheese.

@MarkLautens @glycoworld i'm so sorry to hear this

A very sad day for the Department of Chemistry as we mourn the death of Professor Dwight Seferos. Gone way too young.