Anthony Rullo: chemically modulating proximity
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Anthony Rullo: chemically modulating proximity
@LabRullo
Covalent and multivalent - proximity inducing strategies for basic and translational chemical biology
Katılım Haziran 2019
555 Takip Edilen932 Takipçiler

Happy to share some recent work in the lab developing covalent peptides to reprogram antibody targeting function bpspubs.onlinelibrary.wiley.com/doi/epdf/10.11…
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U of T, McMaster anchor new venture capital fund to back life sciences spinouts via @globeandmail ow.ly/QlIK50ZlACj
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Welcome Senior Editor Anthony Rullo, MSc, PhD, who works in covalent and multivalent approaches for induced proximity, covalent electrophile development and physical organic characterization, and synthetic immunotherapeutics. @LabRullo @McMasterU

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@MCT_AACR @McMasterU excited to be a part of this !
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@basktastic @OlzmannLab congratulations !
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Excited and grateful to have been promoted to Professor. Many thanks to the outstanding students and postdocs in my lab and to my colleagues at Cornell and across the #chembio and #lipidtime communities for your continued support!

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Multispecific T-cell engagers attract cancer drug developers
nature.com/articles/d4157…
Multispecific T-cell engagers that bind three or more targets on cancer and immune cells promise to address the shortcomings of their bispecific predecessors

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Cell-type specific bioorthogonal chemistry using enzyme-activated caged tetrazines
nature.com/articles/s4158…

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@chemuoft @MarkLautens an excellent teacher who ignited my passion for physical organic chemistry, congratulations !
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Chemistry Stories: Mark Taylor receives Chair’s Distinguished Teaching Award. uoft.me/TaylorTeaching…

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Multi-equilibria systems offer a highly regulated control over pathway selection & switching.
End-result: chemical platform to discover new reactions, targets, and opportunities
Credit @RAJIB__MOLLA, @Dwaipayan_13, and team at @chm_iiserb, @iiserbhopal
cell.com/cell-reports-p…
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Triazenyl Furans as Diels–Alder Dienes | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
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Linker-Driven Sampling of PROTAC-Induced Ternary Complexes | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…
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A new series of covalent, monovalent glue degraders can co-opt two E3 ligases, DCAF16 and FBBXO22, in a parallel fashion to degrade SMARCA2/4 with chemically and genetically tunable ligase preference
nature.com/articles/s4158…
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It‘s time to remove the question mark!
A huge congrats to @CraigMCrews, Ray Deshaies and the scientists @ArvinasInc.
1st FDA approval for a #PROTAC on May 1st 2026. A day to remember. Extra drinks at the Proxidrugs GRC in a few weeks!

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Fast and Selective Labeling of Serine and Threonine in HFIP for Facile Editing of Peptide Alcohol Side Chains | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…
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Just out @J_A_C_S Confined Acids Catalyze a Broadly Applicable β-Selective O-Glycosylation
pubs.acs.org/doi/10.1021/ja…
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Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulation | ACS Chemical Biology pubs.acs.org/doi/10.1021/ac…
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