Spagnoli Lab

So excited to share our new paper today @Nature Truly interdisciplinary study: #computational modelling, #lineagetracing and #scRNASeq uncovers sustained plasticity in hepato-pancreato-biliary development (1/2) disq.us/t/40i2bhl @LabSpagnoli @KCLstemcells @kingsmedicine

Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoids biorxiv.org/content/10.648… #biorxiv_devbio

New research from Professor Francesca Spagnoli reveals how different cell types develop, assemble, and communicate to build a functioning pancreas.🧬 kcl.ac.uk/news/research-… Image credit: Alejo Torres-Cano et al. Sci. Adv. 11,eadx5791(2025). DOI: 10.1126/sciadv.adx5791

🚨 here it is the #DashBoard accompanying our new paper (see 🧵 below) ➡️ …al-pancreatic-maps.sites.er.kcl.ac.uk 😃 have fun exploring the dataset & #spatial #maps 🗺️ 👏 👏 Kudo to Sami (#SiwanartaMa) MSc Bioinformatics for building the #DashBoard !!

Spatially organized cellular communities shape functional tissue architecture in the pancreas | Science Advances science.org/doi/10.1126/sc…

Congrats Alejo Torres-Cano postdoc in the @LabSpagnoli @KCLstemcells

🙏🙏 all our fundings @EUCouncil @wellcometrust @NC3Rs #FundaciónAlfonsoMartínEscudero #postdoc support @KCLBMBioscience @BT1DUK #T1DGrandChallenge @DiabetesUK for next step of these discoveries

We built ‘maps’ 💻showing that pancreatic progenitors and nearby supporting cells form niches & used #stemcells 🧫to recreate pancreatic niches in the lab 🧪 & study how human beta cells develop 🙏 the Editor #ScienceAdvances & reviewers for great insights and comments

🚨 Check out our new paper is now online in its final version!!! 🎉 👏 Congratulations Alejo Torres-Cano, who led the study + past & current team @LabSpagnoli + collaborators #VigilanteLab @kingsmedicine ➡️ doi.org/10.1126/scia...

📢 📢Delighted to announce our latest pre-print co-led by our fantastic and talented postdocs @IreneFaravelli and @bolanosAnton 👩🏻‍🔬👩🏼‍🔬💪! Human cortical organoids record developmental time for 5 years in vitro. 🧫🧠⏳. A huge collaborative effort, big thanks to all co-authors! 🧵👇

Dr. Lori Sussel, Director of the CU Diabetes Research Center, recently delivered a keynote lecture titled “Unraveling the Regulation of Islet Cell Fates” at the European Islet Study Group Meeting in Malmö, Sweden. The event was hosted by the Lund University Diabetes Center.

Image analysis opportunity in our lab @TheCrick - deadline June 25 crick.ac.uk/careers-study/…

@IldemAkerman @BreakthroughT1D @BT1DUK Thank You for the donation!!! 😀

@LabSpagnoli @BreakthroughT1D @BT1DUK Good luck!!

My Lab. and I are doing it again!! 🚶‍♀️🚶🏃‍♀️10K One Walk London for T1D research !!! Please help us raise funds for Breakthrough T1D! Your support will help change the lives of everyone affected with T1D - Thanks so much! support.breakthrought1d.org.uk/st/316/t @BreakthroughT1D @BT1DUK

Join us in Lausanne 🇨🇭 for the Lac Léman Regenerative Medicine Symposium, Sept 17–19, 2025! 🔬 Stem cells, aging, bioengineering — shaping the future of regenerative medicine. habiblab.org/l2rm 🎟️ Students 25 CHF | Postdocs/Faculty 50 CHF | Industry 150 CHF #L2RM

@tejlovell @BT1DUK Thanks for inviting me!

A fantastic @BT1DUK Fundraising & Engagement Away Day - inspiration, innovation, recognition and celebration! Proud of the whole team and the incredible progress and passion to raise funds and engagement for our critical work in #t1d #dreamteam

🚨Announcement! We extended the abstract submission deadline to Monday 7th of April! Don't miss this chance to present your work and win one of our prizes 🏆 @TheCrick @the_Node @YEN_community @InesSequeira7 @robhynds @STEMCELLTech @STEMCELLTech @Crick_SCF @GOS_ICH_SCI

Don't forget to secure your place and submit your abstract for the LSCN 8th Annual Symposium! 🔗Registration: eventbrite.co.uk/e/8th-annual-l… Website: lscn.co.uk (where the final agenda will be published soon) Abstract submission (deadline 04/04!) docs.google.com/forms/d/e/1FAI…