Spagnoli Lab

So excited to share our new paper today @Nature Truly interdisciplinary study: #computational modelling, #lineagetracing and #scRNASeq uncovers sustained plasticity in hepato-pancreato-biliary development (1/2) disq.us/t/40i2bhl @LabSpagnoli @KCLstemcells @kingsmedicine

📣 New PRBB-CRG conference 📋 Mapping progenitor niche dynamics for regulation of cell fate 🗣️ Francesca Spagnoli (@LabSpagnoli) - @KCLstemcells 📆 May 22 - ⏰ 12:00 hosted by: @1jorgeferrer - @CRGenomica 📍 #PRBB Maria Skłodowska-Curie room

🎇Great fun writing this #review with #AlejoTorresCano, highly talented postdoc in @LabSpagnoli 🤔reflecting on the emergence of #pancreatic #lineages in the #embryo through the lens of #plasticity @wellcometrust @kingsmedicine @BreakthroughT1D @DUK_research

Drs. Alejo Torres-Cano (@LabSpagnoli) and Francesca Spagnoli explore how cellular plasticity and microenvironmental interactions drive #PancreaticDevelopment, regeneration, and disease, with implications for therapies for diabetes and pancreatic cancer. Read the #review in @NatRevGastroHep: go.nature.com/4fjnL3m

🎉 Very happy to have had the opportunity to contribute to this latest @DiseasePrimers #Review on #PancreaticCancer together with a number of great colleagues! @ednacukierman @EileenMOReilly @SaurLab @BarbaraGrnwald ... Hope it is a useful read! 😊💜 nature.com/articles/s4157…

My department at Oxford is recruiting junior faculty to the Ludwig Institute for Cancer Research. A collaborative and stimulating department, with great access to the breadth of the Oxford environment. The positions come with core funding and cutting edge technologies. If interested, apply here: shorturl.at/1ggGt

Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoids biorxiv.org/content/10.648… #biorxiv_devbio

New research from Professor Francesca Spagnoli reveals how different cell types develop, assemble, and communicate to build a functioning pancreas.🧬 kcl.ac.uk/news/research-… Image credit: Alejo Torres-Cano et al. Sci. Adv. 11,eadx5791(2025). DOI: 10.1126/sciadv.adx5791

🚨 here it is the #DashBoard accompanying our new paper (see 🧵 below) ➡️ …al-pancreatic-maps.sites.er.kcl.ac.uk 😃 have fun exploring the dataset & #spatial #maps 🗺️ 👏 👏 Kudo to Sami (#SiwanartaMa) MSc Bioinformatics for building the #DashBoard !!

Spatially organized cellular communities shape functional tissue architecture in the pancreas | Science Advances science.org/doi/10.1126/sc…

Congrats Alejo Torres-Cano postdoc in the @LabSpagnoli @KCLstemcells

🙏🙏 all our fundings @EUCouncil @wellcometrust @NC3Rs #FundaciónAlfonsoMartínEscudero #postdoc support @KCLBMBioscience @BT1DUK #T1DGrandChallenge @DiabetesUK for next step of these discoveries

We built ‘maps’ 💻showing that pancreatic progenitors and nearby supporting cells form niches & used #stemcells 🧫to recreate pancreatic niches in the lab 🧪 & study how human beta cells develop 🙏 the Editor #ScienceAdvances & reviewers for great insights and comments

🚨 Check out our new paper is now online in its final version!!! 🎉 👏 Congratulations Alejo Torres-Cano, who led the study + past & current team @LabSpagnoli + collaborators #VigilanteLab @kingsmedicine ➡️ doi.org/10.1126/scia...

📢 📢Delighted to announce our latest pre-print co-led by our fantastic and talented postdocs @IreneFaravelli and @bolanosAnton 👩🏻‍🔬👩🏼‍🔬💪! Human cortical organoids record developmental time for 5 years in vitro. 🧫🧠⏳. A huge collaborative effort, big thanks to all co-authors! 🧵👇

Dr. Lori Sussel, Director of the CU Diabetes Research Center, recently delivered a keynote lecture titled “Unraveling the Regulation of Islet Cell Fates” at the European Islet Study Group Meeting in Malmö, Sweden. The event was hosted by the Lund University Diabetes Center.

Image analysis opportunity in our lab @TheCrick - deadline June 25 crick.ac.uk/careers-study/…

@IldemAkerman @BreakthroughT1D @BT1DUK Thank You for the donation!!! 😀

@LabSpagnoli @BreakthroughT1D @BT1DUK Good luck!!

My Lab. and I are doing it again!! 🚶‍♀️🚶🏃‍♀️10K One Walk London for T1D research !!! Please help us raise funds for Breakthrough T1D! Your support will help change the lives of everyone affected with T1D - Thanks so much! support.breakthrought1d.org.uk/st/316/t @BreakthroughT1D @BT1DUK