Thomas Laval

Preprint alert! A role for the ESCRT protein HRS in hepatocyte lipophagy. Congratulations authors @mwillzzz411, @ankit_shroff, and Bridget Crossman (@UWMadison )! biorxiv.org/content/10.110… @UNMC_Biochem @unmc

Long-chain fatty acids can be carbon sources for pathogens but are also potent antimicrobials. In our latest work, we explored the question of how Mycobacterium tuberculosis avoids getting killed by a preferred carbon source. biorxiv.org/content/10.110…

Halmos et al show that the deficiency of cholesterol transporters #Abca1 & #Abcg1 in #SMCs enhances #vasoconstriction & urinary #bladder distension but does not affect lesion area in #atherosclerosis. Learn more at ahajrnls.org/3FaMG9b @SluimerJudithHelle @hfj22

Happy to share our last paper published in m bio. A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio journals.asm.org/doi/10.1128/mb…

A HUGE Cuervo Lab effort exploring sex and age differences of CMA activity was published in @NatureAging today! Check out the publication nature.com/articles/s4358… and the @EinsteinMed press release montefioreeinstein.org/news/2025/02/0… !!

Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt and @healycl without who this would not have been possible 😘 Find us on @bluesky now journals.asm.org/doi/10.1128/mb…

How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 sciencedirect.com/science/articl…

rdcu.be/dMdQ9   Excited and proud to see the final version of our manuscript out @NatureComms, describing a new lipid droplet reporter mouse, which allows staining-free fluorescent visualization of #LipidDroplets!! Check out how numerous they are in the brain!

Our latest work on #liver lipophagy and Rab5 is published in Hepatology Communications today! #alcohol @AASLDtweets journals.lww.com/hepcomm/fullte… Major findings in thread below:

🫧 Special Issue! #LipidDroplets in Health and Disease 👩‍🔬 Guest editors: @MariaBohnert & @BiancaSchrul ➡️ bit.ly/44SET8Z 16 reviews highlight new discoveries in the lipid droplet lifecycle and insights into diseases related to lipid storage. @wwu_muenster @Saar_Uni

@CAPSACPP is thrilled to see new investments in Canadian postdocs in #Budget2024! $825M to support future research talent. $1.8B to support grants. Federal postdoctoral fellowships will be increasing from $40k to $70k! An amazing investment in our research talent 🎉

#GradStudent scholarships and #Postdoc fellowships got a raise today for the first time in 21 years🙌 Immensely grateful to all those who have been pushing for this. It truly takes a village! Still processing and will have more thoughts soon! But overall this👇 is great news!

Following a rigorous international recruitment process, the University of Ottawa Heart Institute has named Dr. Katey Rayner as its next chief scientific officer and vice-president of research. Congratulations! ow.ly/vue050Rcg9g @KateyRayner #ottnews

Excited to announce our work on Dietary #protein, #leucine, #macrophage, #mtor, and #CVD (#atherosclerosis) published in @NatMetabolism. First authors @XiangyuZ0321, Dr. Divya kapoor, & collaborators did a fantastic translational and mechanistic study. nature.com/articles/s4225…

Finally out there - Recognition of yeast β-glucan particles triggers immunometabolic signa... sciencedirect.com/science/articl… Tweetorial Follows (1/12)

I am thrilled to share our work describing the role of Aster proteins in intestinal physiology! Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake | Science science.org/doi/full/10.11…

🚨🚨 POSTDOC ADVERT!!! We offer a postdoc position focused on metabolism of macrophages and dendritic cells and their targeting for immunotherapy of cardiovascular diseases. I will be very grateful if you can distribute the advert🙏 cnic.es/en/investigaci…

New paper alert! The PhD work of @LeahSusser is now online. Leah found that mitochondrial dynamics (fission + fusion) are critical for resolution responses in macrophages. 1/ tandfonline.com/doi/full/10.10…

Check out @ia_windham’s review on the Cell Biology of APOE in the Brain. Such a fascinating protein with so many open questions! @ApoEdscvr nam12.safelinks.protection.outlook.com/?url=https%3A%…

Preprint alert! We are happy to introduce Contact-FP, a suite of probes for studying #MembraneContactSite dynamics. This was an amazing team effort led by Research Associate @GregoryMiner18 and postbacc Sidney Smith 1/11 biorxiv.org/content/10.110…